Primary Gastric Inflammatory Myofibroblastic Tumor in an Adult—Case Report With Brief Review

Abstract

The term inflammatory myofibroblastic tumor more commonly referred to as "pseudostumor ", denotes a pseudosarcomatous inflammatory lesion that contains spindle cells, myofibroblasts, plasma cells, lymphocytes and histiocytes. It exhibits a variable biological behavior that ranges from frequently benign lesions to more aggressive variants. Inflammatory myofibroblastic tumor (IMT) of the stomach is extremely rare and its prognosis is unpredictable. We present a 45-year-old diabetic man with a gastric Inflammatory myofibroblastic tumor. The histopathological and immunohistochemical analysis was the key to reach diagnosis.

Computed tomographic features of inflammatory myofibroblastic tumour of the stomach in adult patients: An analysis of five multicentre cases with literature review

“…Therefore, for thorough diagnostic workup, contrast‐enhanced abdominal CT is usually performed under suspicion of malignancy. To date, only nine sporadic case reports focusing on the clinical, endoscopic or pathological features of gastric IMTs in adult patients have been published with brief descriptions of concurrently performed CT scans . With our five cases included, we evaluated the CT features of 14 adult cases of gastric IMTs.…”

“…We also searched PubMed for reports containing the keywords 'inflammatory myofibroblastic tumor' or 'inflammatory pseudotumor' and 'gastric' or 'stomach'. Only nine cases reported in the English literature included figures of contrast enhanced abdominal CT. 9,[13][14][15][16][17][18][19][20] The CT features of those tumours were also evaluated based on…”

“…These variable radiological features could be due to varying degrees of fibrosis, cellular infiltration and dynamic changes in the inflammatory process. Because IMT rarely occurs in adults, particularly in the stomach, most previous reports of gastric IMT were of single cases . Also, to the best of our knowledge, those reports focused on the clinical or pathological aspects of the tumour and not on radiological features.…”

“…Because IMT rarely occurs in adults, particularly in the stomach, 3,8,9 most previous reports of gastric IMT were of single cases. 9,[13][14][15][16][17][18][19][20] Also, to the best of our knowledge, those reports focused on the clinical or pathological aspects of the tumour and not on radiological features. Therefore, we report five cases of gastric IMTs in adult patients from four tertiary referral centres with a description of the radiological features on CT, along with a review of the literature on such tumours.…”

Inflammatory myofibroblastic tumor of the hand: A case report

“…At the molecular level, positive immunohistochemical staining of ALK is observed in ~40-100% of IMT cases, depending on the anatomical sites at which they arise (2,7). Clinically, the majority of IMTs are benign, but they require adequate surgical treatment, as they have a tendency for local recurrence (8). IMTs exhibit a predilection for children and adolescents are are considered to metastasize in ≤5% of cases (2).…”