Primary Gastric Lymphoma: Clinicopathological Profile

Malipatel, Renuka; Patil, Mallikarjun; P, Pritilata Rout; Correa, Marjorie; Devarbhavi, Harshad

doi:10.5005/jp-journals-10018-1250

Cited by 16 publications

(8 citation statements)

References 120 publications

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“…However, median age at diagnosis in our study was 44 years, which was one decade earlier as compared to the presentation of primary gastric lymphoma as reported by us in the previous studies and in concordance with other studies. 15 , 17 …”

Section: Discussionmentioning

confidence: 99%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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A bstract Introduction Gastrointestinal (GI) tract is the most common site of extranodal lymphoma accounting for 30–40% of the cases. In Western countries, stomach is the most common site of GI lymphoma, whereas in the Middle East and Mediterranean countries, small intestine is commonly involved. Studies about primary intestinal lymphoma (PIL) are heterogeneous in anatomical distribution, presentation, and histological subtypes. The present study was aimed at studying the anatomical distribution, histological subtypes, and clinical characteristics at tertiary care centers. Materials and methods The present study was retrospective, conducted between 2006 and 2020. Patient's data were collected from institutional medical records. PIL was diagnosed by Lewin's criteria. After histological diagnosis, PIL was classified as per the World Health Organization (WHO) criteria and staging was done according to the Ann Arbor classification as modified by Musshoff. Results A total of 941 lymphoma cases were diagnosed during the study period between 2006 and 2020 consisting of 238 Hodgkin's lymphoma and 703 non-Hodgkin's lymphoma (NHL) cases. PIL constituted 5.8% of all lymphoma cases (55 out of 941) and 50.9% (55 of 108) of all primary GI lymphoma. Median age at diagnosis was 44 years and comprised predominantly males (85.45%). Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma were the most common histological subtype (78%) seen. Two patients with primary Hodgkin's lymphoma involving the intestine were seen. T-cell lymphoma was seen in three (5.4%) patients. Ileocecal region was the most common site involved (27%). The common presenting complaints were intestinal obstruction (40%) requiring surgical resection and abdominal pain (32%). Majority of the patients presented in the early stages (I and II). Conclusion Our study demonstrates the pattern of distribution and various histological subtypes of PIL including the rare variants like primary intestinal Hodgkin's lymphoma. Relatively more number of patients presented with intestinal obstruction requiring surgery in comparison with other studies. How to cite this article Malipatel R, Patil M, Rout P, et al . Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients. Euroasian J Hepato-Gastroenterol 2021;11(2):71–75.

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Section: Discussionmentioning

confidence: 99%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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“…Stomach was the most frequently involved site (63.6%), followed by small intestinal (14.6%) while other parts were rarely involved. [4][5][6][7][8] Among them, most PGIL were derived from B-cell (93.6%). The most common pathological types were DLBCL and MALT lymphoma.…”

Section: Discussionmentioning

confidence: 99%

<p>A Retrospective Analysis of Primary Gastrointestinal Non-Hodgkin Lymphomas: Clinical Features, Prognostic Factors and Treatment Outcomes</p>

Tian

Chen

2020

OTT

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Introduction: Primary gastrointestinal non-Hodgkin lymphoma (PGIL) is a rare hematopoietic malignancy with limited data to guide management. Methods: We analyzed the clinical characteristics and survival of 219 newly diagnosed PGIL patients. Results: Our single-center data showed that the incidence rate of primary gastric lymphoma (PGL) was higher than that of primary intestine lymphoma (PIL). Most PGIL was B-cell originated and DLBCL was the most common pathological type both in PGL and PIL group. Univariate and multivariate analysis showed that IPI score and pathology were independent prognostic factors. The overall survival (OS) and progression-free survival (PFS) of patients with MYC rearrangement were much shorter compared to patients without MYC rearrangement indicating that MYC translocation was related to decreased survival. Neither OS nor PFS differed between patients who received chemotherapy with or without surgery. However, patients who received surgery alone had a poor prognosis. Conclusion: Chemotherapy is the front-line treatment for PGIL while surgery was conducted to relieve tumor-related complications or make diagnosis. MYC rearrangement predicted poor prognosis of PGIL patients.

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“…For cases to be considered suitable for evaluation, ≥25% area of a tissue slice had to be available for morphologic analysis following staining and at least one positively stained tumor-infiltrating macrophage was required as a positive internal control. Analysis of IHC staining of CD3, CD5, CD8, CD10 and CD20 was performed according to the manufacturers' protocols and as previously reported ( 32 ).…”

Section: Methodsmentioning

confidence: 99%

Exosomal PD‑L1 promotes the formation of an immunosuppressive microenvironment in gastric diffuse large B‑cell lymphoma

Zeng

Wang

et al. 2023

Oncol Rep

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Gastric diffuse large B-cell lymphoma (GDLBCL) is a common disease with an increasing incidence. However, the regulatory effect of exosomal programmed death-ligand 1 (PD-L1) on the immune microenvironment in GDLBCL is unclear. In the present study, the protein expression levels of exosomal PD-L1 in the supernatants of cultured diffuse large B-cell lymphoma (DLBCL) cells and the plasma of patients with GDLBCL was assessed using immunoblotting. Exosomes derived from DLBCL cells were cocultured with T lymphocytes or injected into tumor xenograft mice by tail vein injection. The relationship between the protein expression level of exosomal PD-L1 in the plasma and the clinical characteristics and immune microenvironmental parameters of GDLBCL was evaluated using immunoblotting and immunohistochemistry. High levels of exosomal PD-L1 were found in the supernatants of cultured DLBCL cells. Exosomes with high levels of PD-L1 promoted growth of tumors formed by DLBCL cells in vivo and inhibited the proliferation of T lymphocytes. Notably, the protein expression level of PD-L1 in plasma exosomes derived from GDLBCL patients was significantly higher than that of healthy individuals. High levels of PD-L1 in plasma exosomes were significantly associated with international prognostic index score, pathological type and advanced Lugano stage, which might lead to the poor prognosis of GDLBCL. Moreover, a high level of PD-L1 in plasma exosomes was significantly associated with an immunosuppressive microenvironment in GDLBCL. Therefore, the results of the present study indicated that exosomal PD-L1 inhibited the proliferation of T lymphocytes and promoted the formation of an immunosuppressive microenvironment in GDLBCL. High expression of exosomal PD-L1 may suggest a poor prognosis of GDLBCL, and exosomal PD-L1 in plasma may be a new diagnostic indicator for GDLBCL.

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Primary Gastric Lymphoma: Clinicopathological Profile

Cited by 16 publications

References 120 publications

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

<p>A Retrospective Analysis of Primary Gastrointestinal Non-Hodgkin Lymphomas: Clinical Features, Prognostic Factors and Treatment Outcomes</p>

Exosomal PD‑L1 promotes the formation of an immunosuppressive microenvironment in gastric diffuse large B‑cell lymphoma

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