Primary Gastric Melanoma with Rhabdoid Features: A Case Report

Kim, Na Rae; Lee, Woon Kee; Chung, Dong Hae

doi:10.4132/koreanjpathol.2013.47.6.606

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Search of the literature resulted in 599 articles. Twenty‐five case reports fulfilled our inclusion criteria and were included in this systematic review 1–4,16–36 . Figure 1 presents the trial flow of our study.…”

Section: Resultsmentioning

confidence: 99%

Primary gastric melanoma in adult population: a systematic review of the literature

Schizas

Tomara

Katsaros

et al. 2020

ANZ Journal of Surgery

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Background Primary gastric melanoma (PGM) is a rare malignant tumour of the stomach with poor prognosis. The aim of this systematic review was to assess the available literature on this entity and to highlight its biological behaviour and preferred treatment approach. Methods PubMed and Cochrane bibliographical databases were independently searched (last search: 2 February 2020) by two investigators for articles reporting on PGM in the adult population. Results Twenty‐five studies met the inclusion criteria and concerned collectively 25 patients (18 males and seven females) with an age of 63.4 ± 8.97 years (mean ± standard deviation). Main symptoms included abdominal pain (64%), weight loss (48%) and hematemesis or melena (32%). The most frequent tumour location was the body of the stomach (54.2%). All tumours were surgically resected and the majority of the patients had a partial gastrectomy (52%). Median recurrence time was 5 months and 12% of patients reached 5‐year survival landmark. Conclusion PGM is a rare disease characterized by an aggressive malignant behaviour. Its differential diagnosis from a metastatic lesion is crucial. A prompt diagnosis and therapeutic approach are needed. Further studies are required to elucidate the optimal management of this clinical entity.

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Section: Resultsmentioning

confidence: 99%

Primary gastric melanoma in adult population: a systematic review of the literature

Schizas

Tomara

Katsaros

et al. 2020

ANZ Journal of Surgery

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“…As far as we know, the vast majority of gastrointestinal melanomas are metastases from skinderived lesions. However, we have found 12 cases of primary gastrointestinal melanoma in the literature (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

Primary gastric melanoma with pancreatic metastasis: a case report

Xiao

et al. 2021

Ann Palliat Med

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We report an extremely rare case of primary gastric melanoma with pancreatic metastasis. As far as we know, the concept of primary gastrointestinal melanoma is currently controversial, because there are very few reports of primary gastrointestinal melanoma. At the same time, isolated pancreatic metastases are also very rare. The patient was admitted to the hospital with a main complaint of decreased appetite, and then underwent gastroscopy and found a mass in the stomach. The mass was initially diagnosed as poorly differentiated adenocarcinoma following a gastroscopic biopsy. The patient underwent radical total gastrectomy, pancreatic body and tail resection, splenectomy, and Roux-en-Y esophagojejunostomy. After further immunohistochemical examination of the surgically removed tissue, malignant melanoma was diagnosed. The tumor cells were arranged in sheets or nests with infiltrating growth, the cell sizes were inconsistent, nucleoli were obvious, and melanin particles were seen in the cytoplasm of some cells. The tumor cells were positive for MITF and S-100. Detailed systemic and imaging examinations did not find any other primary lesions. The patient denied any melanoma and skin lesion history. We believe this is a manifestation of primary gastric melanoma. We report this rare case of gastric melanoma with the aim of increasing clinicians' awareness of non-cutaneous melanoma and its treatment methods.

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“…It has been demonstrated that the survival times for patients who undergo surgery compared to those who do not are 12 months and 2 months, respectively [3]. The use of adjuvant chemotherapy may improve the results of treatment [7], whereas radiotherapy may be considered a method of palliative treatment [8].…”

Section: Discussionmentioning

confidence: 99%