Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia

Oono, Yasuhiro; Fu, Kuang I.; Nagahisa, Emiko; Kuwata, Taiji; Ikematsu, Hiroaki; Yano, Tomoaki; Kojima, Takane; Minashi, Keiko; Fujii, Shouichi; Ochiai, Atsushi; Kikuchi, Kentaro

doi:10.1055/s-0030-1255807

Cited by 15 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15,18,19 One hypothesis, the most likely in our opinion, is that proposed by Boswell and Helwig, 16 which suggests that squamous cell carcinoma of the stomach develops from a metaplastic squamous focus. The existence of this, though very rare, has been described around peptic ulcers, 16 following ingestion of a corrosive agent, 20 in one case of linitis plastica associated with congenital syphilis, 21 and during long-term chemotherapy treatment in a case of lymphocytic lymphoma.…”

Section: Discussionmentioning

confidence: 95%

Primary Squamous Cell Carcinoma of the Stomach

González-Sánchez

Vitón

Collantes

et al. 2017

Clin Med Insights Oncol

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) of the stomach is a rare entity. There are several theories regarding the development of this tumor, but its pathogenesis remains obscure. Fewer than 100 cases of primary SCC of the stomach have been published in the literature. Due to advanced stage at the time of diagnosis in most of these cases, the prognosis is generally poor. In the case presented here, endoscopy revealed a vegetative tumor in the stomach described as SCC by biopsy. Following curative surgery, adjuvant chemotherapy was administered; however, the patient died 3 years and 4 months after surgery after recurrence was diagnosed.

show abstract

Section: Discussionmentioning

confidence: 95%

Primary Squamous Cell Carcinoma of the Stomach

González-Sánchez

Vitón

Collantes

et al. 2017

Clin Med Insights Oncol

View full text Add to dashboard Cite

show abstract

“…It seems that squamous metaplasia occurs accidentally, motivated by repeated detriment on gastric mucosa. Although it is unknown whether gastric squamous metaplasia leads to squamous carcinoma or not, it could sometimes give rise to squamous cell carcinoma of the stomach in some reports 1,5,10. Accordingly, endoscopic surveillance is essential for patients with gastric squamous metaplasia.…”

Section: Discussionmentioning

confidence: 99%

A Case of Squamous Metaplasia of the Stomach

et al. 2013

View full text Add to dashboard Cite

Intestinal metaplasia of the stomach is a common metaplastic lesion associated with chronic gastritis and mucosal atrophy. However, squamous metaplasia is a comparatively rare condition. On endoscopy, squamous metaplasia is usually observed as a whitish mucosal lesion in the lesser curvature of the cardiac region of the stomach. When Lugol's iodine solution is applied, the lesion stains brown in the same way as normal esophageal mucosa. We report a case of 79-year-old man with a whitish flat lesion in the lesser curvature of the cardiac region on surveillance endoscopy after endoscopic treatment of gastric adenoma. The endoscopic biopsy showed stratified squamous epithelial mucosa.

show abstract

“…The pathogenesis of SCC in the stomach and duodenum has not been well-elucidated. Several theories regarding the origin of SCC in the stomach and duodenum have been proposed, including nests of ectopic squamous cells, the proliferation of uncommitted mucosal basal cells into squamous cells, squamous metaplasia secondary to chronic mucosal damage, squamous differentiation in a preexisting adenocarcinonma and multipotent stem cells in the gastrointestinal mucosa [7,10,11]. Endoscopically, nearly all the meatastatic cases present as submucosal tumors with bridging folds and small ulcerations at the top, termed volcano-like ulcers [5,12].…”

Section: Discussionmentioning

confidence: 99%

Gastric and duodenal squamous cell carcinoma: metastatic or primary?

Zhu

Mei

et al. 2013

World J Surg Onc

View full text Add to dashboard Cite

Either metastatic or primary squamous cell carcinoma in the gastrointestinal tract is extremely rare, with very few cases reported in the literature. In this paper, we report a case in which the patient presented with dysphagia during the course of radiotherapy for recurrent lung cancer in a mediastinal lymph node. Although the dysphagia mimicked radiation esophagitis, the ultimate cause proved to be gastric and duodenal metastases from primary lung squamous cell carcinoma. Taking into account the value of identification of metastatic or primary SCC in the stomach and duodenum on the prognosis and treatment options, it is imperative that the correct diagnosis be established. This report is followed by a discussion of the differential diagnosis between metastatic and primary squamous cell carcinoma in the stomach and duodenum.

show abstract

Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia

Cited by 15 publications

References 0 publications

Primary Squamous Cell Carcinoma of the Stomach

Primary Squamous Cell Carcinoma of the Stomach

A Case of Squamous Metaplasia of the Stomach

Gastric and duodenal squamous cell carcinoma: metastatic or primary?

Contact Info

Product

Resources

About