Primary gastric T-cell lymphoma of suppressor-cytotoxic (CD8+) phenotype: Discordant expression of T-cell receptor subunit βF1, CD7, and CD3 antigens

Banerjee, Diponkar; Walton, John C.; Jory, T.; Crukley, Catherine; Meek, M

doi:10.1016/0046-8177(90)90060-i

Cited by 22 publications

(9 citation statements)

References 10 publications

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“…Such cases usually occur in association with infection by human T‐lymphotropic virus type 1 (HTLV‐1), especially in endemic areas such as Japan. In contrast, rare cases of primary gastric T‐cell lymphoma without HTLV‐1 infection are reported sporadically, but their pathogenesis is still unclear 4–16 . Most cases of primary gastric T‐cell lymphoma consist of large, pleomorphic lymphoma cells with a helper/inducer phenotype, but a minority have MALT lymphoma‐like bland cytological features and a cytotoxic phenotype 4–13 .…”

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confidence: 99%

Gastric T‐cell lymphoma with cytotoxic phenotype

Sugita

Iijima²,

Furuya

et al. 2007

Pathology International

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Primary gastric lymphoma usually originates from B cells of mucosa-associated lymphoid tissue (MALT) infected with Helicobacter pylori. When T-cell lymphomas develop in the stomach, they usually occur in association with infection by human T-lymphotropic virus type 1 and gastric involvement of adult T-cell leukemia. Reported herein is a unique and informative case of gastric peripheral T-cell lymphoma with a cytotoxic phenotype that histologically mimicked, and had to be carefully distinguished from, MALT-type B-cell lymphoma. The patient, a 73-year-old woman, underwent a gastric endoscopy examination, and the histological findings suggested MALT-type gastric lymphoma. Analysis of the immunoglobulin heavy chain (IgH) gene and T cell receptor gamma (TCRgamma) gene revealed monoclonal rearrangement of the TCRgamma gene. The tumor cells exhibited mild atypia and immunoreactivity with anti-CD3, anti-CD8, anti-T-cell intracellular antigen-1, antigranzyme B and antiperforin antibodies, but not with anti-CD20, anti-CD10, and anti-CD79a antibodies. The case was finally diagnosed as gastric T-cell lymphoma with cytotoxic phenotype, and this was confirmed after surgical resection. In cases such as this, small biopsy specimens from the stomach should be examined carefully for low grade B-cell-type malignant lymphoma (MALT lymphoma), because sometimes the proliferating B cells can hide the truly malignant T cells, and rearrangement analysis is useful for diagnosing T-cell malignancy.

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confidence: 99%

Gastric T‐cell lymphoma with cytotoxic phenotype

Sugita

Iijima²,

Furuya

et al. 2007

Pathology International

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“…Furthermore, several studies have reported cases of T‐cell lymphomas associated with chronic Helicobacter pylori or Epstein–Barr virus (EBV) infection 12–15 . Most of the cases described had a CD4+ helper/inducer phenotype, but cases featuring CD8+ cytotoxic/suppressor or even a natural killer (NK) phenotype have also been reported 9,15–19 . CD103 expression was found in a few cases, suggesting their derivation from intraepithelial T‐lymphocytes (IEL) 11,19,20 …”

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confidence: 99%

Frequent expression of CD30 antigen in the primary gastric non‐B, non‐Hodgkin lymphomas

Iwamizu-Watanabe

Yamashita

Yatabe

et al. 2004

Pathology International

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Most primary gastric lymphomas are of B-cell origin. Fourteen cases of primary gastric non-B, non-Hodgkin lymphomas were studied to evaluate their clinicopathological and immunophenotypic findings. The cases were comprised of 11 men and three women, with a median age of 56.5 years. Most patients underwent surgery either with or without chemotherapy, exhibiting a 5 year survival rate of 57.5%. Morphologically, the neoplastic cells showed various histological features, such as anaplastic large cell lymphoma (ALCL) (n = 3), peripheral T-cell lymphoma, unspecified, large (n = 4), medium-sized (n = 2) and mixed cell (n = 5). Two cases displayed a non-B, non-T cell phenotype, whereas the remaining cases displayed a T-cell phenotype. Six cases were CD4+, while two were CD8+. The neoplastic cells were CD30+ in 10 cases. TIA-1 was positive in six cases. In one case, anaplastic large cell lymphoma kinase (ALK) was identified with immunostaining and chromosomal rearrangement of ALK was detected by fluorescence in situ hybridization (FISH). In conclusion, although the mechanism of CD30 expression is unknown, primary gastric non-B, non-Hodgkin lymphomas tend to express CD30. We consider that some of the cases in the present study may be derived from cytotoxic T cells, similar to systemic and cutaneous ALCL, the majority of which exhibit TIA-1.

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“…Four patients had no residual disease after surgery and chemotherapy [17,23,31,38,41]. Two out of 3 reported patients with a CD8+ phenotype died within 6 months after diagnosis, while 1 had no residual disease after 6 months of follow-up [3,14,40].We present three cases of primary gastric T-cell lymphoma with a CD3+, CD4+, CD8+ phenotype with a very aggressive course and the death of patients 6-12 months after surgery and subsequent chemo/radiotherapy. Immunohistology of the three cases revealed an almost identical immunophenotype.…”

Section: Discussionmentioning

confidence: 99%

“…Since the first description by Weis et al in 1986 [40] fewer than 40 cases have been reported [3,12,14,17,18,23,24,26,28,30,31,38,41]. Most of the cases described had a CD4+ helper/inducer phenotype [17,26,38].…”

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confidence: 90%

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Primary gastric apoptosis-rich T-cell lymphoma co-expressing CD4, CD8, and cytotoxic molecules

et al. 2000

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In contrast to primary gastric lymphomas of B-cell type, little is known about primary gastric T-cell lymphomas. We describe three cases with remarkably similar features: diffuse growth, epitheliotropism, medium too large cell size, high apoptotic rates, and a CD3+, CD4+, CD8+, CD45RO+ immunophenotype. Clonal TCRgamma gene rearrangement was shown in two cases. Epstein-Barr virus infection was excluded in two cases. Taking advantage of fresh-frozen material, we analyzed two cases further, revealing CD5-, CD16+, CD56-, CD57-, CD25+, CD30+, CD103 (alphaEbeta7)+, bcl-2 protein+, CD95+, CD95 ligand(L)-. CD95L, however, was detected in histiocytic and fibroblastoid by stander cells. The lymphomas expressed granzyme B, perforin, and the TIA-1 antigen in various combinations. All three cases had a very unfavorable clinical course characterized by local recurrence and/or dissemination to other epithelial sites, leading to death within 6-12 months after the initial diagnosis despite surgery and aggressive antineoplastic treatment. These data suggest a novel variant of peripheral T-cell lymphoma operationally characterized as primary gastric, apoptosis-rich, CD103+, EBV-, T-cell lymphoma co-expressing CD4, CD8, CD16 and cytotoxic molecules.

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Primary gastric T-cell lymphoma of suppressor-cytotoxic (CD8+) phenotype: Discordant expression of T-cell receptor subunit βF1, CD7, and CD3 antigens

Cited by 22 publications

References 10 publications

Gastric T‐cell lymphoma with cytotoxic phenotype

Gastric T‐cell lymphoma with cytotoxic phenotype

Frequent expression of CD30 antigen in the primary gastric non‐B, non‐Hodgkin lymphomas

Primary gastric apoptosis-rich T-cell lymphoma co-expressing CD4, CD8, and cytotoxic molecules

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