Primary gastrointestinal anaplastic large cell lymphoma

Lee, Yi‐Ying; Takata, Katsuyoshi; Wang, Ren‐Ching; Yang, Sheau-Fang; Chuang, Shih‐Sung

doi:10.1016/j.pathol.2017.05.007

Cited by 11 publications

(12 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, EATL type 2 is the most common intestinal lymphoma in cats but is uncommon in dogs and typically exhibits a more indolent behavior. 11,23 Histologically, it is characterized by small- to intermediate-sized lymphoid cells that predominantly infiltrate the intestinal mucosa and rarely cause necrosis. 11,23 In humans, EATL is strongly linked to inflammatory bowel disease.…”

mentioning

confidence: 99%

Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs

Stranahan

Whitley²,

Thaiwong

et al. 2019

Vet Pathol

View full text Add to dashboard Cite

Anaplastic large T-cell lymphoma (ALTCL) is a rare subtype of non-Hodgkin T-cell lymphoma that occasionally occurs in the gastrointestinal tract of humans. Enteropathy-associated T-cell lymphoma (EATL) type 1 is the most common type of intestinal lymphoma in dogs, and ALTCL has not previously been reported in the intestinal tract of dogs. Thirteen dogs with intestinal masses diagnosed as intestinal lymphoma with anaplastic morphology were reviewed. Clinical data, including treatment protocols, were available for 11 cases. Immunohistochemistry for CD3, CD20, and CD30 was performed for all cases in addition to PCR for Antigen Receptor Rearrangements (PARR) for assessment of clonality. Eight (62%) of the cases presented with intestinal perforation, and all cases had 1 or more masses arising from the small intestine. Histologically, all cases were characterized by transmural infiltrates of large, CD3-positive and frequently CD30-positive cells. Neoplastic T cells had marked anisocytosis and anisokaryosis, prominent nucleoli, and occasionally indented to reniform nuclei. There was abundant necrosis and inflammation with occasional vascular invasion within neoplastic masses. All cases had a monoclonal T-cell receptor γ gene rearrangement. The median survival time was 5 days, with 1 dog surviving 2 years after the initial diagnosis. ALTCL can occur as an aggressive transmural lymphoma in the gastrointestinal tract of dogs and commonly causes intestinal perforation. ALTCL can be differentiated from EATL type 1 and might have implications for accurate prognostication and selection of therapeutic options in the future.

show abstract

mentioning

confidence: 99%

Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs

Stranahan

Whitley²,

Thaiwong

et al. 2019

Vet Pathol

View full text Add to dashboard Cite

show abstract

“…According to a recent review on gastrointestinal ALCL, the rate of ALK expression among gastrointestinal ALCL was low at 24%[11]. As far as we can determine, ALK+ ALCL of the gut has been reported in only eleven cases[11-20]. The clinical features are summarized in Table 2 for a total of 12 gastrointestinal ALK+ ALCL cases, including our patient.…”

Section: Discussionmentioning

confidence: 83%

“…Regardless of ALK expression, primary gastrointestinal ALCL is rarer[10]. According to a recent review on gastrointestinal ALCL, the rate of ALK expression among gastrointestinal ALCL was low at 24%[11]. As far as we can determine, ALK+ ALCL of the gut has been reported in only eleven cases[11-20].…”

Section: Discussionmentioning

confidence: 99%

“…Of these, four cases were reported to involve the esophagus[12-15], all showing fungating tumors. Of the remaining cases, two involved the stomach[11,16], one involved the duodenum[17], one involved both the stomach and duodenum[18], and three involved the small intestine (jejunum/ileum)[11,19,20]. Only three of these last seven cases showed macroscopic findings by resection or endoscopy; the morphology showed a mass formation pattern, such as a submucosal or bulky tumor.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review

Saito¹,

Izumiyama²,

Ogasawara³

et al. 2019

WJCC

View full text Add to dashboard Cite

BACKGROUND Anaplastic large cell lymphoma (ALCL) is a type of T-cell lymphoma that can be divided into two categories: anaplastic lymphoma kinase-positive (ALK+) and ALK-negative. Gastrointestinal ALK+ ALCL is rare. Multiple lymphomatous polyposis (MLP) is thought to be a representative form of gastrointestinal lesion in mantle cell lymphoma, and T-cell lymphomas seldom show this feature. Here, we report the first known case of ALK+ ALCL with gastroduodenal involvement to present with MLP. CASE SUMMARY The patient was a 43-year-old man who was complained of a mass in the left inguinal area and was performed open biopsy. ALK+ ALCL was diagnosed pathologically. Computed tomography scan demonstrated multiple lymph node lesions in the abdomen - pelvis/inguinal region, and scattered nodular lesions in both lung fields. He did not complain of gastrointestinal symptoms. While, esophagogastroduodenoscopy identified MLP lesions from the antrum of the stomach to the descending portion of the duodenum and mild thickened folds on the corpus of the stomach, and biopsy showed invasion of ALK+ ALCL. We treated this patient with six cycles of CHOEP (Cyclophosphamide, Doxorubicin, Vincristine, Etoposide, and Prednisone) chemotherapy. At the conclusion of treatment, there was complete remission. Numerous white scars were found on the stomach, endoscopically consistent with a remission image of lymphoma. The endoscopic features of this case were thought to be similar to those of MCL. CONCLUSION The macroscopic/endoscopic features of gastrointestinal ALK+ ALCL may be more similar to those of B-cell lymphomas rather than T-cell lymphomas.

show abstract

“…The most frequent extranodal involvement sites are the skin, lungs, bone, and liver[7,8], whereas the colon is rarely reported as being involved[3,9]. To the best of our knowledge, there have only been 9 such cases reported in 4 papers written in English[10-13]. Three of those reports were case reports, and no review has focused on this rare presentation.…”

Section: Introductionmentioning

confidence: 99%

Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet's disease: A case report and review of literature

Luo

Jiang

Lei

et al. 2019

WJCC

View full text Add to dashboard Cite

BACKGROUNDAnaplastic large cell lymphoma (ALCL) is a CD30-positive T cell lymphoma, a rare type of non-Hodgkin lymphoma. The current World Health Organization classification system divides ALCLs into anaplastic lymphoma kinase (ALK)-positive and ALK-negative groups. ALCL rarely presents in the gastrointestinal tract.CASE SUMMARYA 54-year-old male was admitted to the department of gastroenterology for abdominal pain. He presented with lower abdominal pain, diarrhea and recurrent oral and penile ulcers. He was misdiagnosed with Behcet's disease and treated with prednisone. But after one month, he was hospitalized in another hospital for reexamination. This time, the lesion on the penis was biopsied for histological examination. The final pathological diagnosis was ALCL, ALK-negative. The patient was treated with cyclophosphamide, doxorubicin, vincristine, prednisolone chemotherapy. However, he died within one month.CONCLUSIONGastrointestinal ALCL needs to be considered in the differential diagnosis to avoid delaying treatment. Repeated biopsy is the most important for early diagnosis and treatment.

show abstract

Primary gastrointestinal anaplastic large cell lymphoma

Cited by 11 publications

References 37 publications

Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs

Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs

ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review

Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet's disease: A case report and review of literature

Contact Info

Product

Resources

About