Primary gastrointestinal stromal tumor of the liver: a case report and review of the literature

Nagai, Takeshi; Ueda, Kazumitsu; Hakoda, Hiroyuki; Okata, Shinya; Nakata, Shoko; Taira, Tetsuro; Aoki, Shigeo; Mishima, Hideyuki; Sako, Akihiro; Maruyama, Tsunehiko; Okumura, Minoru

doi:10.1186/s40792-016-0218-6

Cited by 13 publications

(14 citation statements)

References 27 publications

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“…Although several GISTs arising from outside of the gastrointestinal tract have been reported [4, 5, 6], they represent only 1% of all GISTs of defined origin [12]. Concerning the hepatobiliary system, only 9 cases including the clinicopathological features and the treatment outcomes of primary hepatic GISTs have been reported [9]. Eight of 9 cases were resected, and the other case underwent radiofrequency ablation [9].…”

Section: Discussionmentioning

confidence: 99%

“…Concerning the hepatobiliary system, only 9 cases including the clinicopathological features and the treatment outcomes of primary hepatic GISTs have been reported [9]. Eight of 9 cases were resected, and the other case underwent radiofrequency ablation [9].…”

Section: Discussionmentioning

confidence: 99%

“…To examine the aspect of a hepatic tumor, imaging modalities play a pivotal role. MRI was performed in 3 cases; however, no characteristic findings were obtained [9]. FDG-PET was performed in 3 patients with hepatic GISTs, and high accumulation of FDG was found in hepatic tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Although no ICCs have presented in human hepatocytes, primary hepatic GISTs have been barely reported [9]. Almost all cases of primary hepatic GISTs were resected because they had no distal metastasis [9]. On the other hand, few cases of primary hepatic GISTs with cystic changes have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Primary Gastrointestinal Stromal Tumor of the Liver with Cystic Changes

Tashiro¹,

Uwamori²,

Nakade³

et al. 2019

Case Rep Gastroenterol

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Gastrointestinal stromal tumors (GISTs) are known to originate specifically from the intestinal cells of Cajal located in the gastrointestinal mesenchyme. GISTs developing outside of the digestive tract have barely been reported. We encountered a first case of large primary GISTs in the liver with cystic changes. A 63-year-old man with a past history of brain infarction visited our hospital. The computed tomography (CT) revealed a 6-cm and a 10-cm mass in the right and the caudal lobe of the liver, respectively. These tumors have marginal enhancement in the arterial phase; however, they presented as hypodense in the internal tumor sites. Both liver tumors had cystic changes. Gastrointestinal examinations using endoscopy revealed no other gastrointestinal tumors, and [¹⁸F]-fluoro-2-deoxy-D-glucose positron emission tomography/CT revealed multiple bone metastases in addition to the liver tumors. The liver tumor specimens were composed of spindle cells, and the immunohistochemical staining for c-Kit and for DOG1, as discovered on GIST, was positive. The patient was diagnosed with primary hepatic GIST with cystic changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Gastrointestinal Stromal Tumor of the Liver with Cystic Changes

Tashiro¹,

Uwamori²,

Nakade³

et al. 2019

Case Rep Gastroenterol

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“…Because PET-CT has essential value in diagnosis and staging, prediction of malignant potential, treatment decision, efficacy assessment, and follow-up monitoring, it has been clinically recognized and included in the 2010 National Comprehensive Cancer Network Guide Guidelines Medium[ 6 ]. In the literature, PET-CT was used to exclude liver GIST from extrahepatic lesions with a maximum standardized uptake value of 6.30-6.85[ 28 , 32 ]. Importantly, even if patients have a characteristic image without a history of hepatitis and alpha-fetoprotein levels are not elevated, the possibility of PHGIST should be considered in the differential diagnosis.…”

Section: Imaging and Pathological Diagnosismentioning

confidence: 99%

Prevalence, diagnosis, and treatment of primary hepatic gastrointestinal stromal tumors

Qian¹,

Yan²,

Gao³

et al. 2020

WJG

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Gastrointestinal stromal tumors (GIST), which is the most common mesenchymal tumor of the digestive tract, account for 1%-3% of gastrointestinal tumors. Primary stromal tumors outside the gastrointestinal tract are collectively referred to as extra GISTs, and stromal tumors in different regions often have different prognoses. A primary hepatic GIST is a rare tumor with an unknown origin, which may be related to interstitial Cajal-like cells. Although primary hepatic GIST has certain characteristics on imaging, it lacks specific symptoms and signs; thus, the final diagnosis depends on pathological and genetic evidence. This review summarizes all cases of primary hepatic GIST described in the literature and comprehensively analyzes the detailed clinical data of all patients. In terms of treatment, local resection alone or with adjuvant therapy was the prioritized choice to obtain better disease-free survival and longer survival time. For advanced unresectable cases, imatinib mesylate was applied as the first-line chemotherapy agent. Moreover, transcatheter arterial chemoembolization, radiofrequency ablation, and microwave ablation were shown to improve overall survival for selected patients. Liver transplantation was a final treatment option after resistance to chemotherapy developed.

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