Primary gastrointestinal stromal tumors: Current advances in diagnostic biomarkers, prognostic factors and management of its duodenal location

Zhong, Yi; Deng, Meihai; Liu, Bo; Chen, Cheng; Li, Mingliang; Xu, Rui‐hua

doi:10.5582/irdr.2013.v2.1.11

Cited by 10 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All GISTs that occurred in the intestines had more than a moderate possibility of metastasis when they were > 5 cm or had > 5 mitoses/50 HPFs. In tumors < 5 cm with a mitotic count < 5/50 HPFs, the intestinal GISTs had a low probability of metastasis[ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

Hayashi¹,

Kamimura²,

Hosaka³

et al. 2017

WJGE

View full text Add to dashboard Cite

Duodenal gastrointestinal stromal tumors (GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure.

show abstract

Section: Discussionmentioning

confidence: 99%

Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

Hayashi¹,

Kamimura²,

Hosaka³

et al. 2017

WJGE

View full text Add to dashboard Cite

show abstract

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract [1], although they account for only 1–3% of all gastrointestinal tumors [2]. They grow relatively slowly, producing no specific symptoms, and 60–70% originate from the stomach [3–5].…”

Section: Introductionmentioning

confidence: 99%

Giant gastrointestinal stromal tumor of the mediastinum associated with an esophageal hiatal hernia and chest discomfort: a case report

et al. 2018

View full text Add to dashboard Cite

BackgroundGastrointestinal stromal tumors (GISTs) grow relatively slowly and without specific symptoms; therefore, they are typically incidental findings. We report a rare gastric GIST in the mediastinum associated with chest discomfort and an esophageal hiatal hernia.Case presentationAn 81-year-old woman with chest discomfort was admitted to the hospital, where barium esophagography showed a sliding esophageal hiatal hernia and a tumor of the lower esophagus and gastric wall. Esophagogastroscopy confirmed the presence of a huge submucosal tumor that extended from the lower esophagus to the gastric fundus. According to computed tomography, the mediastinal mass measured 12.7 cm and had heterogeneous low-density areas. A submucosal gastric tumor, which we suspected to be a GIST, was diagnosed in association with an esophageal hiatal hernia. Using thoracolaparotomy, we performed a total gastrectomy, a lower esophagectomy, and a Roux-en-Y reconstruction with the jejunum. The presumptive diagnosis was confirmed through immunohistochemical examination; immunostaining yielded results positive for CD34 and c-kit. The patient was discharged from the hospital 13 days after surgery with no complications and remained disease-free at follow-up 24 months after surgery.ConclusionsGIST should be considered in the differential diagnosis of tumors growing in the mediastinum.

show abstract

Safety and efficacy of surgical and endoscopic resection in the treatment of duodenal subepithelial lesions

Liang

Wang

et al. 2021

Surg Endosc

View full text Add to dashboard Cite

Primary gastrointestinal stromal tumors: Current advances in diagnostic biomarkers, prognostic factors and management of its duodenal location

Cited by 10 publications

References 59 publications

Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

Giant gastrointestinal stromal tumor of the mediastinum associated with an esophageal hiatal hernia and chest discomfort: a case report

Safety and efficacy of surgical and endoscopic resection in the treatment of duodenal subepithelial lesions

Contact Info

Product

Resources

About