Primary genitourinary melanoma

Nguyen, An; Kavolius, Jeffrey; Russo, Paul; Grimaldi, Greg; Katz, Jared; Brady, Mary S.

doi:10.1016/s0090-4295(00)01107-9

Cited by 29 publications

(21 citation statements)

References 24 publications

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“…Despite its rare incidence in clinical practice, early diagnosis and distinction of primary malignant melanoma of prostate from prostate epithelial cancer is an extremely important matter, because while prostate cancer can be treated as a chronic disease for years, malignant melanoma of the prostate can have rapid high mortality 1 . To the best of our knowledge, very few cases have been reported nation‐wide 2–5 .…”

Section: Introductionmentioning

confidence: 99%

Primary malignant melanoma of the prostate

Liu

Sun²

2009

Int J of Urology

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Abstract:Although the incidence is extremely rare in clinical practice, due to its highly aggressive behavior and a similar presentation as prostate cancer, the primary malignant melanoma of the prostate should be given more attention. We report a case in a 29-year-old male who presented with one-month history of dysuria. Based on clinical examination, ultrasound and computed tomography imaging, surgical operation and histopathological studies, a definitive diagnosis was made. Further characteristic images and pathology of this disease are discussed.

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Section: Introductionmentioning

confidence: 99%

Primary malignant melanoma of the prostate

Liu

Sun²

2009

Int J of Urology

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“…1 The former condition is exceptionally rare, accounting for less than 1% of all cases of melanoma, 2 and can affect the penis, urethra, and scrotum in descending frequency. 3 They usually present as longstanding lesions that often are misdiagnosed due to nonspecific symptoms or gross similarity to benign (vascular) lesions.…”

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confidence: 99%

“…3 They usually present as longstanding lesions that often are misdiagnosed due to nonspecific symptoms or gross similarity to benign (vascular) lesions. In the largest series of primary genitourinary melanomas published, 2 it is suggested that those presenting in the scrotal region have a more favourable prognosis. We report a case of primary malignant melanoma of the scrotum, with particular reference to the cytomorphological features.…”

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confidence: 99%

A rare case of primary malignant melanoma of the scrotum diagnosed by fine‐needle aspiration

Damala

Tsanou

Pappa

et al. 2004

Diagnostic Cytopathology

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We report a case of a 55-yr-old man with malignant melanoma of scrotum. He was referred to our Hospital with a complaint of gradual focal enlargement of the scrotum in a period of 3 yr. On physical examination, a pigmented, poorly marginated mass, with central necrosis was observed. A fine-needle aspiration (FNA) of the lesion was performed. Cytological examination revealed highly cellular smears, containing malignant cells, dispersed or arranged in loose aggregates. Cellular morphology and characteristics were identical to those of malignant melanoma arising elsewhere in the skin. The immunocytochemical study revealed positivity of neoplastic cells for anti-melanoma monoclonal antibody (HMB-45) antigen. Histological confirmation finally was provided after wide excision of the lesion. We emphasize the difficulties in differential diagnosis considerations and diagnostic pitfalls of scrotal lesions.

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“…In clinical stages B or C, a routine bilateral ilio-inguinocrural dissection (BIICD) has palliative indication only to reduce local complications owing to the high volume of disease [1, 16]. The prognosis for the non-localised stages is poor, with a reported two-year survival rate of 0% despite multiple treatments [3]; nonetheless, the prognosis in clinical stage B is variable depending on the disease volume.…”

Section: Discussionmentioning

confidence: 99%

Penile melanoma: a 20-Year analysis of six patients at the National Cancer Institute of Peru, Lima

Jabiles¹,

Mar²,

Pérez³

et al. 2017

ecancer

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Melanoma of the urogenital tract is extremely rare, accounting for less than 0.1% of melanoma cases. The global literature currently describes only 220 cases of penile melanoma, most commonly located on the glans penis.ResultsPenile melanoma accounts for 0.7% of penile cancers and 0.18% of melanoma cases. The average patient age for the six cases we reviewed was 44.5 years. Three of these cases (50%) involved ulceration, one case (16.7%) involved lymphovascular invasion, and three cases (50%) involved mitosis ≥ 1 mm2 (0.38–4.7 mm). The average depth of invasion (Breslow) in the five cases that reported this measure was 2.1 mm (0.38–4.7 mm). Applying the American Joint Committee on Cancer tumour, node, metastases (AJCC TNM) staging system, one case was Tx (16.7%), two cases were T1 (33.3%), one case was T2 (16.7%), one case was T3 (16.7%), and one case was T4 (16.7%). Five cases (83.3%) involved wide local resection, and only one case involved partial penile amputation. Four cases (66.7%) involved primary bilateral inguinocrural lymphadenectomy, and only one of those four cases involved lymphatic metastatic disease. One case (16.7%) involved lymphatic recurrence at 12 months in a patient who survived 38 months. One case (16.7%) involved local recurrence at 13 months in a patient who has survived 53 months. Eighty per cent of these patients remain alive, with no evidence of disease after an average follow-up of 96.7 months.ConclusionPenile melanoma prognosis depends on the initial clinical stage of the disease. The risk of lymphatic involvement seems to be related to the same risk factors used to assess cutaneous melanoma. Clinicians can thus assess penile melanoma using the AJCC staging system. The use of sentinel lymph node biopsy to determine staging is also becoming more common and could replace prophylactic bilateral inguinal dissection.

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Primary genitourinary melanoma

Cited by 29 publications

References 24 publications

Primary malignant melanoma of the prostate

Primary malignant melanoma of the prostate

A rare case of primary malignant melanoma of the scrotum diagnosed by fine‐needle aspiration

Penile melanoma: a 20-Year analysis of six patients at the National Cancer Institute of Peru, Lima

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