Primary glomerular diseases in Brazil (1979  1999): is the frequency of focal and segmental glomerulosclerosis increasing?

Bahiense-Oliveira, Marilia; Saldanha, Luís Balthazar; Moţa, E; Penna, Domenico; Barros, Rui Toledo; Romão-Junior, J E

doi:10.5414/cnp61090

Cited by 50 publications

(36 citation statements)

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“…8,25 MPGN was also found to decrease significantly (9.30% in period 1 versus 0.72% in period 4) (p < 0.001), which had been reported since 1985, [14][15][16][17]20,28 because of the improvement in standards of living and public health, as well as the early effective treatment of infections. Changing trend of FSGS that was reported to increase in other countries, 11,13,14,[18][19][20][21]23 was controversial in our study, for the proportion of FSGS increased from 1.74% in period 1 and 1.55% in period 2 to 5.57% in period 3 (p < 0.05, p < 0.001, respectively) and then decreased to 3.09% in period 4 (p < 0.001). Additionally, there was no significant variation in the proportion of EnPGN and CreGN along the periods (p > 0.05) The most common pathological type of secondary GD type was LN (47.35%), and LN was the mainly secondary GD in the 15-45-year-old group (54.74%) and the 45-59-year-old group (28.77%), moreover, LN was common cause in patients with AKI (12.24%) and CKI (11.05%).…”

Section: Discussioncontrasting

confidence: 59%

“…12,13 Recently, an increasing number of studies demonstrate that the spectrum of biopsy-proven renal diseases has changed over the past three decades in other counties 7,11,[13][14][15][16][17][18][19][20][21][22][23] and in northern and southern China. 4,8,24,25 Nephrotic syndrome (NS) is reported to be the main indication for renal biopsy in other countries 10,12,14,22 and northern China, 4,24,26 except Japan, 6 where the leading indication is asymptomatic proteinuria and/or hematuria.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Ning

Shi

et al. 2016

Renal Failure

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The purpose of this study is to investigate the changing spectrum and clinicopathologic correlation of biopsy-proven renal diseases in central China. We retrospectively analyzed data of 4931 patients who underwent renal biopsy in ten hospitals between September 1994 and December 2014. Among them, 81.55% were primary glomerular diseases (GD), and 13.02% were secondary GD. IgA nephropathy (IgAN) was the most common primary GD (43.45%), followed by focal glomerulonephritis (16.79%), mesangial proliferative glomerulonephritis (MsPGN, 14.35%), and membranous nephropathy (MN, 13.28%). IgAN was leading primary GD in patients under 60 years old, while MN was the leading one over 60 years old. The most frequent secondary GD was lupus nephritis (LN) (47.35%). The prevalence of IgAN, MN and minimal change disease was found to increase significantly (p < 0.001, p < 0.001, and p < 0.01, respectively), while that of MsPGN, membranoproliferative glomerulonephritis and LN decreased significantly (p < 0.001, p < 0.001, and p < 0.05, respectively). The main indication for renal biopsy was proteinuria and hematuria (49.03%), followed by nephrotic syndrome (NS, 20.36%). IgAN was the most common cause in patients with proteinuria and hematuria, chronic-progressive kidney injury, hematuria and acute kidney injury; and MN was the leading cause of NS. Primary GD remained the predominant renal disease in central China. IgAN and LN were the most prevalent histopathologic lesions of primary and secondary GD, respectively. The spectrum of biopsy-proven renal disease had a great change in the past two decades. Proteinuria and hematuria was the main indication for renal biopsy. ARTICLE HISTORY

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Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Ning

Shi

et al. 2016

Renal Failure

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“…Nephrotic syndrome and renal failure are unusual (5%), although at our institution 25% of the patients with IgA nephropathy present nephrotic syndrome (14). Renal failure and hypertension are common, being detected in 59 and 53% of our patients, respectively (14).…”

Section: Introductionmentioning

confidence: 59%

Comparative study of IgA nephropathy with and without crescents

Bitencourt-Dias

Bahiense-Oliveira

Saldanha

et al. 2004

Braz J Med Biol Res

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Glomerular crescents were analyzed as a prognostic factor in retrospectively reviewed data from 144 patients with biopsy-proven IgA nephropathy. Crescents were found in 26 (18%) patients, and detected in 2 to 100% of glomeruli in each specimen. In 5% of the patients more than 50% of the glomeruli were affected. Thirty patients with IgA nephropathy without crescents were studied as a control group. Mean age was 30.3 ± 9.4 and 30.2 ± 12.0 years for the patients with and without crescents, respectively, and males prevailed in both groups. The length of follow-up was 23.2 ± 41.6 months for patients with crescents and 29.3 ± 35.3 months for patients without crescents. Eighty percent of the patients with crescents were hypertensive, compared to 27% of the non-crescent control group (P < 0.05). Mean serum creatinine at the time of diagnosis was 3.9 ± 2.9 and 1.9 ± 2.1 mg/dl for the patients with and without crescents, respectively. Initial urinary protein excretion was higher in patients with crescents (4.6 ± 3.5 vs 1.2 ± 0.9 g/day; P < 0.05). At the end of follow-up 17 patients (77.3%) from the crescent group and 3 (11.1%) from the non-crescent group had end-stage renal disease (P < 0.0001). The presence of crescents was associated with higher levels of initial serum creatinine and urinary protein excretion, and a higher frequency of hypertension and progression to end-stage renal disease.

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“…According to several authors, the worldwide incidence of FSGS is on the rise annually, including in Brazilian statistics (1,8,9) . Data from the Paulista registry of glomerulopathies shows that FSGS is the most common primary glomerulopathy in 11 centers of São Paulo, accounting for 29.7% of cases, followed by membranous nephropathy (20.7%) and immunoglobulin A (IgA) nephropathy (17.8%) (12) .…”

Section: Introductionmentioning

confidence: 99%

Study of the morphologic variants of focal segmental glomerulosclerosis: a Brazilian report

Testagrossa¹,

Malheiros²

2012

J. Bras. Patol. Med. Lab.

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Primary glomerular diseases in Brazil (1979 1999): is the frequency of focal and segmental glomerulosclerosis increasing?

Cited by 50 publications

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Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Comparative study of IgA nephropathy with and without crescents

Study of the morphologic variants of focal segmental glomerulosclerosis: a Brazilian report

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Primary glomerular diseases in Brazil (1979  1999): is the frequency of focal and segmental glomerulosclerosis increasing?

Cited by 50 publications

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Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Comparative study of IgA nephropathy with and without crescents

Study of the morphologic variants of focal segmental glomerulosclerosis: a Brazilian report

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Primary glomerular diseases in Brazil (1979 1999): is the frequency of focal and segmental glomerulosclerosis increasing?