Primary graft dysfunction after liver transplantation

Chui, A.K.K; Shi, Liwei; Rao, Archana; Anasuya, A.; Hagl, Christian; Pillay, Praga; Verran, Deborah; McCaughan, Geoffrey W.; Sheil, A. G. R.

doi:10.1016/s0041-1345(00)01642-0

Cited by 24 publications

(16 citation statements)

References 6 publications

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“…PDF includes both PNF and initial poor function 24–26. Because some trials reported the incidence of PDF, whereas PNF or DGF alone was presented in other trials, the data for PDF, PNF, and DGF were separately in our meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

Histidine-tryptophan-ketoglutarate solution vs. University of Wisconsin solution for liver transplantation: A systematic review

Zhao

Yao

et al. 2007

Liver Transpl

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University of Wisconsin (UW) solution has been recognized as the gold standard in liver preservation, but its limitations are becoming obvious, such as risk of biliary complications and its high cost. Alternatively, the effects of histidine-tryptophanketoglutarate (HTK), such as improved biliary protection and low cost, have been observed. This systematic review is conducted to compare the efficacy and safety of these 2 solutions. Databases from 1966 to June 2006 were searched. Randomized clinical trials (RCTs) and cohort studies comparing HTK and UW solutions for liver transplantation were included. Ten articles including 11 comparisons (1,200 patients) met the inclusion criteria, containing 2 RCTs and 9 cohort studies. No marked differences existed between the 2 groups in patient and graft survival rates, acute rejection, primary nonfunction, primary dysfunction, delayed graft function, and ALT and AST levels after transplantation. The only positive result was observed in the bile production after deceased donor liver transplantation (DDLT), which was statistically significantly higher in HTK group than that of UW group (95% confidence interval, 18.65-57.47; P ϭ 0.0001). Although the difference in biliary complications between the 2 groups did not reach statistical significance, HTK was thought to be more effective for biliary tract flush and prevention of biliary complications in some studies. There was no statistically significant difference of effects (except bile production) between HTK and UW. But trends were documented in some studies for the superiority of HTK in biliary tract flush, prevention of biliary complications, and cost saving. Adequately powered RCTs with longer follow-up periods are required to evaluate the long-term effect of these 2 solutions.

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Section: Resultsmentioning

confidence: 99%

Histidine-tryptophan-ketoglutarate solution vs. University of Wisconsin solution for liver transplantation: A systematic review

Zhao

Yao

et al. 2007

Liver Transpl

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“…Initial Poor Graft Dysfunction and Primary Graft Non-Function After Orthotopic Liver Transplantation 185 and 0.93%, respectively in Chui et al's investigation (Chui et al, 2000). In the study by Chen et al, the rates of IPGF and PGNF were 36.25% and 1.3%, respectively (Chen et al, 2007).…”

Section: Clinical Featuresmentioning

confidence: 95%

“…References Graded initial liver function (Gonzalez et al, 1994) Severe: sum of score 7-9 Moderate: 5 or 6 Mild: 3 or 4 AST > 2000 IU/L and prothrombin time >16 s (Ploeg et al, 1994) on days 2-7 ALT > 2500 IU/L within 3 days (Ardite et al, 1999) AST or ALT > 2500 IU/L within 24 hours (Chui et al, 2000) ALT or AST > 1500 IU/L within the first 3 days (Nanashima et al, 2002) PGNF is manifested by hepatic cytolysis and rapidly rising transaminases, absence of bile production, severe liver-related coagulation deficit, hypoglycemia, high lactate levels, and hepatic hemodynamic instability (Uemura et al, 2007). According to the United Network for Organ Sharing (UNOS), PGNF is defined as irreversible graft function requiring emergency liver replacement during the first 10 days after liver transplantation.…”

Section: Definitions Of Ipgfmentioning

confidence: 99%

Initial Poor Graft Dysfunction and Primary Graft Non-Function After Orthotopic Liver Transplantation

Chen¹,

Xie²,

Shen³

et al. 2011

Liver Biopsy in Modern Medicine

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“…Although primary graft dysfunction (PDF) occurs in up to 30% of all allografts, the mechanisms leading to this are still unclear (7). However, there is evidence that apoptosis is involved in the pathogenesis of PDF (8).…”

Section: Introductionmentioning

confidence: 99%

Caspase‐cleaved cytokeratin 18 and 20 S proteasome in liver degeneration

Hetz

Höetzenecker

Hacker

et al. 2007

Clinical Laboratory Analysis

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Apoptosis of epithelial hepatocytes plays a pivotal role in acute as well as in chronic liver diseases. The cleavage of cytokeratin-18 (CK-18) by caspases is an early event in the apoptotic process. We therefore sought to investigate serum levels of CK-18 and 20S proteasome in patients with liver cirrhosis, primary graft dysfunction (PDF), and acute liver failure (ALF), and in healthy volunteers. Enzyme-linked immunosorbent assay (ELISA) was utilized to measure the concentration of M30, a fragment of CK-18 cleaved at Asp396 (M30 neoantigen), and the concentration of 20S proteasome. Serum levels of the CK-18 neoepitope M30 were significantly increased in ALF, primary graft dysfunction, and liver cirrhosis vs. healthy controls (1,993.6+/-124.7 U/L, 2,238.1+/-235.9 U/L, and 673.6+/-86.5 U/L vs. 66.8+/-29.1 U/L, respectively, P<0.001). Similar results were detected with the evaluation of 20S proteasome (124,014.5+/-13,235.6 ng/mL, 76,993.2+/-15,720.1 ng/mL, and 2,395.9+/-1,098.2 ng/mL vs. 1,074.5+/-259.4 ng/mL, respectively; P<0.001). Detection of CK-18 neoepitope M30 and 20S proteasome may represent a novel marker of tracing apoptotic epithelium, respectively mirroring degenerative liver processes in affected patient population.

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Primary graft dysfunction after liver transplantation

Cited by 24 publications

References 6 publications

Histidine-tryptophan-ketoglutarate solution vs. University of Wisconsin solution for liver transplantation: A systematic review

Histidine-tryptophan-ketoglutarate solution vs. University of Wisconsin solution for liver transplantation: A systematic review

Initial Poor Graft Dysfunction and Primary Graft Non-Function After Orthotopic Liver Transplantation

Caspase‐cleaved cytokeratin 18 and 20 S proteasome in liver degeneration

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