Primary granulocytic sarcoma of larynx

Kim, Luke Y.; Purkey, Michael T.; Patel, Mihir R.; Ghosh, Alip; Hartner, Lee; Newman, Jason G.

doi:10.1002/hed.23805

Cited by 9 publications

(13 citation statements)

References 26 publications

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“…Therefore, high clinical suspicion will improve the accuracy of diagnosis using CNB. Excision or debulking surgery may be considered for symptomatic patients with MS for improving the accuracy of their diagnosis and relieving their symptoms [6, 9, 16].…”

Section: Discussionmentioning

confidence: 99%

“…The 2008 World Health Organization (WHO) classification clarified the diagnosis of MS as follows: “a tumor mass consisting of myeloid blasts with or without maturation occurring at an anatomic site other than the bone marrow (BM)” [1, 3, 4]. MS has been described in 2.5–9.11% of patients with acute myeloid leukemia (AML) during the disease course [5, 6]. According to the 2016 WHO classification, MS may include the clinical presentation of any subtype of AML, present de novo (de novo MS), be accompanied by peripheral blood (PB) and BM involvement (MS with PB/BM involvement), present as relapse of AML (relapse of AML), or present as the progression of a prior myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), or both (progression of MDS/MPN) [7, 8].…”

Section: Introductionmentioning

confidence: 99%

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Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Shim

Kim

et al. 2019

BioMed Research International

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Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the parotid gland, through a total parotidectomy with neck dissection. After an extensive histopathological review that included immunohistochemistry, a pathologic diagnosis of MS with infiltration into the sebaceous lymphadenoma with concurrent BM involvement was confirmed. MS is difficult to diagnose accurately; herein, we analyzed the clinical presentations and effectiveness of the various diagnostic methods with a review of the literature. There are 17 cases, including our case, reported in 13 studies. Of the cases in which the salivary glands were affected, 10 involved the parotid gland, six involved the submandibular gland, and one involved both. Isolated invasion of the salivary gland was found in one case of parotid gland invasion and three cases of submandibular gland invasion. In 13 cases, the salivary glands were affected by various other lesions. Although there were no incidences of isolated MS, six patients were diagnosed with secondary MS and eight patients with MS with BM involvement, including this case. The diagnosis of MS is difficult given its rarity, and a high index of suspicion and integrated radiologic and careful histopathologic evaluation are required. Most cases of MS infiltrating the salivary gland might be indicated by the possibility of BM involvement. MS with BM involvement predicts poor prognosis and the need for intensive systemic treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Shim

Kim

et al. 2019

BioMed Research International

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“…[ 5 ] It has been very rare where MS have been reported in association with acute promyelocytic leukemia, CML in blast crisis and myelodysplastic syndrome. [ 4 5 9 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] MS has been described in myriads of location, commonly in skin, gums, lymph nodes, and less often in bones, paranasal sinuses, larynx, orbit, breast, pleura, meninges, and central nervous system. [ 2 3 4 ] Although theoretically possible, MS involving the thyroid gland has never been reported in the English literature. MS is traditionally associated with acute myeloid leukemia (AML) orchronic myeloid leukemia (CML) in blast crisis.…”

Section: Introductionmentioning

confidence: 99%

Mixed phenotypic acute leukemia (mixed myeloid/b-cell) with myeloid sarcoma of the thyroid gland: A rare entity with rarer asssociation - detected on fdg pet/ct

et al. 2017

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Mixed phenotypic acute leukemia (MPAL) is a rare clinical entity. MPAL associated with myeloidsarcoma (MS) is still rarer with only three cases mentioned in English literature. MS has been described in myriads of location, most commonly in skin, gums and lymph nodes. Although theoritically possible, it is very rare to find MS involving the thyroid gland. The diagnosis of MS can be elusive, very often masquerades and mislabeled as lymphoma. A high index of clinical suspicion coupled with PET/CT findings along with morphological clues and thorough peripheral blood, and bone marrow evaluation is mandatory for arriving at the definitive diagnosis. We report the case of a 58-year-old female presenting with thyroid swelling that was subsequently diagnosed to be MS of the thyroid with underlying MPAL (mixed myeloid/B-cell) only after 18F-FDG PET/CT, which revealed an unusual abnormal pattern of multifocal intense FDG uptake in the thyroid gland.

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“…Tsimberidou et al showed reduction in rate of progression to AML in isolated MS patients receiving systemic chemotherapy by 42% compared to patients receiving tumour localized treatment [12] . Isolated MS patients treated with AML based induction regimens have been reported to share similar prognostic features and prolonged disease-free interval [13] .…”

Section: Discussionmentioning

confidence: 99%

Myeloid sarcoma: An unusual and rare laryngeal presentation

Tan¹,

Gendeh

Sani

et al. 2016

International Journal of Surgery Case Reports

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Primary granulocytic sarcoma of larynx

Abstract: The detection of granulocytic sarcoma is difficult given its rarity and nonspecific presentation. To our knowledge, this is the second reported case of primary granulocytic sarcoma of the larynx reported in the literature.

Cited by 9 publications

References 26 publications

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Mixed phenotypic acute leukemia (mixed myeloid/b-cell) with myeloid sarcoma of the thyroid gland: A rare entity with rarer asssociation - detected on fdg pet/ct

Myeloid sarcoma: An unusual and rare laryngeal presentation

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