Primary granulocytic sarcoma of ovary: A rare case report

Clinical report. Primary granulocytic sarcoma: a rare presentation of an ovarian mass

“…Treatment was similar to that for leukemic patients given early chemotherapy as previously reported because patients with primary GS can develop systemic leukemia after diagnosis without any chemotherapy [7,10,11]. In addition, previous studies found that patients with primary GS were at high risk of developing acute leukemia within a year [2,3].…”

“…Primary GS without systemic leukemia is a rare condition [1]. Primary presentation of GS in the female genital tract is extremely rare; most cases present gradually as a mass as previously reported [1][2][3][6][7][8].…”

“…Our patient received a chemotherapeutic regimen for acute myeloid leukemia and developed febrile neutropenia on her second course. As demonstrated by Sreejith et al [1], Mehta et al [2], and Jung et al [7], primary GS may be treated by systemic chemotherapy with good response (remission ranged from 5 to 48 months). On the other hand, Pressler et al showed that two patients underwent surgical procedures without chemotherapy and had a long complete remission (12 months) [6].…”

“…Cells of GS are thought to originate from intramedullary areas of the bone marrow spreading via the Haversian system throughout the entire body [5,9]. Diagnosis is difficult and GS can be misdiagnosed as another hematologic malignancies [7]. Physicians may confuse this with lymphoma and other solid tumors.…”

“…Immunochemical staining such as myeloperoxidase and CD45 staining are useful because they are highly specific for diagnosis. CD43 staining, most often indicate the tumor cells as a T-cell marker, which is also expressed by nearly all GS cells [7,10,11].…”