Primary hepatic lymphoma in a patient with chronic hepatitis B

Matano, Sadaya; Nakamura, Shinobu; Annen, Yusei; Hattori, Noritaka; Kurisu, Kaoru; Kakuta, Kiyoshi; Kyoda, Katsunori; Sugimoto, Tatsuho

doi:10.1016/s0002-9270(98)00529-2

Cited by 10 publications

(6 citation statements)

References 9 publications

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“…On the other hand, a biopsy may reveal a previously unknown lymphoma during the exploration of a solid hepatic mass or after measuring elevated liver enzyme serology [12]. Occasionally, a malignant lymphoma can be detectable in the setting of other liver diseases such as chronic hepatitis B [20, 22], chronic hepatitis C [2, 3, 7, 21, 25], or primary biliary cirrhosis (PBC) [24]. …”

Section: Introductionmentioning

confidence: 99%

Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification

et al. 2007

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The recent World Health Organization (WHO) classification of hematopoietic and lymphoid tissue tumors represents the first worldwide consensus classification of these malignancies. However, the applicability of this classification to a representative number of hepatic lymphomas in liver biopsy specimens has not yet been investigated. The frequency and infiltration pattern of a series of 205 liver biopsies with lymphoma manifestations was analyzed with the aid of immunohistochemical and molecular pathological analyses. Diffuse large B-cell lymphoma (DLBCL) was by far the most frequent entity, comprising 45% of the cases analyzed. Using a previously published immunohistochemical algorithm, 35% of 80 DLBCL were assigned to a germinal center B-cell-like (GCB) and 65% to a non-GCB group. Most B-cell lymphoma entities involving the liver revealed a characteristic infiltration pattern. Diagnostically challenging entities were T-cell-rich B-cell lymphomas, anaplastic large cell lymphomas and peripheral T-cell lymphomas, which frequently required additional molecular clonality assessment. Overall, the percentage of T-cell lymphomas in the liver (12%) was higher as compared to other extranodal sites except for the skin and the small intestine. This study provides relevant data on the distribution of hepatic lymphomas and demonstrates the applicability of the WHO classification proposing a diagnostic algorithm for liver biopsies.

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Section: Introductionmentioning

confidence: 99%

Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification

et al. 2007

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“…Immunosuppression increases the risk of non‐Hodgkin's lymphoma. There is an association with infections with hepatitis C and hepatitis B viruses 10–12 …”

Section: Discussionmentioning

confidence: 99%

Primary hepatic lymphoma: Imaging findings

Elsayes¹,

Menias²,

Willatt³

et al. 2009

J Med Imag Rad Onc

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“…Although he was HbsAg negative his viral load was never checked and therefore we can never be certain that he was without disease. Indeed, in the case from Matano et al [9] immunohistochemical staining demonstrated no replicating virus within the neoplastic cellls although they hypothesised that chronic antigenic stimulation by the virus could be associated with the development of lymphoma rather like other immunological conditions such as Hashimotos thyroiditis and Sjogrens syndrome [10] have been linked to the development of extra nodal lymphomas through the local proliferation of lymphoid tissues. Hepatitis B has a strong correlation with hepatocellular carcinoma though no studies have provided a concrete link with lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Lymphoma: A Diagnosis to Remember

Warner

2012

J Med Cases

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We present 2 cases of PHL presenting to our hospital in the last 6 months. Both cases had similarities in that they had a rapidly progressive time course of less than 8 weeks and radiology failed to illustrate the normal disease pattern. Both were elderly men presenting with jaundice, rare presentations of PHL. One patient was interesting in that he had a bicytopenic blood picture, a common manifestation of PHL, whilst his lactate dehydrogenase was normal. The other had a past history of hepatitis B, interesting for its possible association with PHL. Whilst one patient died prior to treatment, the other was successfully treated with aggressive multidrug chemotherapy. A liver biopsy is essential in any patient where there is a high index of suspicion for PHL based on a bicytopenic blood picture, abnormal liver function tests or radiology. If diagnosed early enough, chemotherapy has proven a successful treatment.

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Primary hepatic lymphoma in a patient with chronic hepatitis B

Cited by 10 publications

References 9 publications

Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification

Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification

Primary hepatic lymphoma: Imaging findings

Primary Hepatic Lymphoma: A Diagnosis to Remember

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