Primary hepatic peripheral T-cell lymphoma: A case report

Hu, Huijuan; Liao, Meiyan; Qu, Yanjuan

doi:10.3892/ol.2014.2119

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…Peripheral T-cell lymphoma (PTCL) primarily manifesting in the liver is considered to be rather uncommon (Andreola et al 1988;Sutton et al 1989;Anthony et al 1990;Shibata et al 1991;Harris and Kornstein 1993;Bowman et al 1994;Lei 1998;Kim et al 2000;Schweiger et al 2000;Levy 2002;Stancu et al 2002;Leung et al 2009;Miyashita et al 2011;Hu et al 2014).…”

Section: Liver Involvement Primary Liver Involvementmentioning

confidence: 99%

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T-Cell Non-Hodgkin’s Lymphomas

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Several types of T-cell non-Hodgkin's lymphomas are characterized by liver involvement, usually in the context of generalized lymphoma disease. The aggressive neoplasm, T-cell prolymphocytic leukemia, showing a proliferation of small-to medium-sized T cells, results in massive bone marrow infiltration and marrow failure but also infiltrates the lymph nodes, liver, and spleen. Hepatic infiltrates mostly involve portal tracts, causing hepatomegaly. Hepatic involvement is a common feature of T-cell large granular lymphocytic leukemia. Liver infiltration is also known for aggressive NK cell leukemia, a systemic proliferation of NK cells almost always associated with EBV infection. The liver may be densely infiltrated by large granular lymphocytes with azurophilic granules. The generalized neoplastic T-lymphocyte process, adult T-cell leukemia/lymphoma, is frequently complicated by focal t diffuse parenchymal or portal tract infiltration of the liver. Other T-cell neoplasms variably involving the liver comprise nasal-type extranodal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, mycosis fungoides, Sézary syndrome, and peripheral T-cell lymphomas. T-Cell Prolymphocytic Leukemia ICD-O Code 9834/3 T-Cell Large Granular Lymphocytic Leukemia ICD-O Code 9831/3 T-cell receptor genes are in germline configuration and, therefore cannot be employed for clonality assessment. A part of the cases reveal clonal del (6)(q21q25) and 11q deletion.

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Section: Liver Involvement Primary Liver Involvementmentioning

confidence: 99%

“…The tumor can present as a liver mass in the absence of lymphadenopathy, splenomegaly, or bone marrow disease (Hu et al 2014). The hepatic manifestation may be a solitary lesion, multiple nodules, or a diffuse infiltration (Levy 2002).…”

Section: Liver Involvement Primary Liver Involvementmentioning

confidence: 99%