Primary hepatocellular carcinoma and hepatitis B virus infection in korea

Chung, Whan Kook; Sun, Hee Sik; Park, Doo Ho; Minuk, Gerald Y.; Hoofnagle, Jay H.

doi:10.1002/jmv.1890110203

Cited by 36 publications

(6 citation statements)

References 14 publications

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“…1,2 In early 1980s, Hann et al 3 presented that there were clustering of chronic carriers of HBV in families of Korean patients with HCC and emphasized the importance of preventive strategy for HBV infection in endemic areas. Since then, several articles [4][5][6] have been reported in Korea, which suggest that chronic HBV infection is a major risk factor for HCC when considering the results of the evaluation for HBsAg and HBeAg status in patients with chronic hepatitis, liver cirrhosis or HCC, as well as control subjects. In 1990s, hepatitis C virus (HCV) was revealed to be another key risk factor for HCCs developing in patients with HBsAg-negative chronic liver disease, especially in those older than 60 years.…”

Section: Introductionmentioning

confidence: 99%

Current status of liver diseases in Korea: Hepatocellular carcinoma

Song

Kim

2009

Korean J Hepatol

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Primary liver cancer, most of which is hepatocellular carcinoma (HCC), is the third common leading cancer in Korea. During the last two decades, the incidence rate of primary liver cancer has shown a modest decrease, but its mortality rate has slightly increased. The incidence of HCC, according to age, peaks in the late sixth decade in men and in the early seventh decade in women. Hepatitis B virus (HBV) is the most important risk factor, which represents approximately 70% of all HCC, and hepatitis C virus (HCV) and alcohol are the next in order of major risk factors for the development of HCC in Korea. HBV-associated HCC occurs 10 years earlier than HCV-associated HCC due to a more prolonged exposure to HBV, which is vertically transmitted almost from HBsAg-positive mother in HBV-endemic area. National Cancer Control Institute, which was reorganized in 2005, is now working for several national projects such as National Cancer Registration Program, National R&D Program for Cancer Control and National Cancer Screening Program. International collaboration for the clinico-epidemiologic research would be needed to provide the specific measures for managing HCC in diverse etiologic situations. Finally, the mechanisms of hepatitis virus-associated hepatocellular carcinogenesis might be clarified to provide insights into the advanced therapeutic and preventive approaches for HCC in Korea, where the majority of HCC originate from chronic HBV and HCV infections.

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Section: Introductionmentioning

confidence: 99%

Current status of liver diseases in Korea: Hepatocellular carcinoma

Song

Kim

2009

Korean J Hepatol

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“…In patients diagnosed with HCC an elevated AFP is an adverse prognostic sign [6,7]. However, this is sufficiently variable that it is of little clinical use.…”

mentioning

confidence: 99%

The resurrection of alphafetoprotein

Sherman

2010

Journal of Hepatology

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“…Italien 94,4, 75 bzw. 65% der Patienten mit HCCs Hepatitis-CVirus(HCV)-Antikörper besitzen [8][9][10][11]. Auch in Deutschland kommt der viralen Hepatitis, neben der alkoholtoxischen Leberzirrhose, eine Hauptrolle in der Pathogenese des HCC zu [12,13].…”

Section: Inzidenz Des Hepatozellulären Karzinoms In Unterschiedlichenunclassified

Epidemiologie und Klinik des hepatozellulären Karzinoms

Kubicka¹,

Manns²

2003

Visc Med

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Epidemiology and Clinical Presentation of Hepatocellular Carcinoma Hepatocellular carcinomas are one of the main complications of liver cirrhosis and a serious health problem worldwide. The incidence of hepatocellular carcinoma varies between different countries, depending on the prevalence of several risk factors such as chronic viral hepatitis B or C, contamination of food with aflatoxin, and alcohol abuse. The incidence of hepatocellular carcinoma is low in developed Western countries, but in some areas of Africa or China, hepatocellular carcinoma is the major cause of tumor-related death. The incidence of hepatocellular carcinoma is rising in all developed Western countries, which can be explained, at least in part, by the increasing prevalence of hepatitis C virus infection. The development of hepatocellular carcinoma in patients with chronic hepatitis C infection needs approximately 20–30 years. Consequently, it has been predicted that the burden of hepatocellular carcinoma in developed Western countries will increase in the next 2–3 decades, possibly to equal rates as currently experienced in Japan. Although liver cirrhosis per se appears to be the primary risk factor for hepatocellular carcinoma, hepatocarcinogenesis strongly depends also on the causes of liver cirrhosis. Depending on the underlying disease, patients with high risk (chronic viral hepatitis B or C, hemochromatosis, tyrosinemia) and those with low risk (morbus Wilson, primary biliary cirrhosis, primary sclerosing cholangitis) for the development of hepatocellular carcinoma can be identified. The prognosis of patients with hepatocellular carcinoma is independent of the underlying disease, but depends on the liver function and the tumor stage.

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Primary hepatocellular carcinoma and hepatitis B virus infection in korea

Cited by 36 publications

References 14 publications

Current status of liver diseases in Korea: Hepatocellular carcinoma

Current status of liver diseases in Korea: Hepatocellular carcinoma

The resurrection of alphafetoprotein

Epidemiologie und Klinik des hepatozellulären Karzinoms

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