Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

Abstract

Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL.

Pancreatic diffuse large B-cell lymphoma: a case report and literature review

“…Primary pancreatic lymphoma (PPL) is an extremely rare malignant tumor that accounts for 1% and 0.5% of all extranodal malignant lymphomas and pancreatic tumors, respectively (1). PPL is more common in men than in women, and its average age of onset is 53 years (2). The clinical and radiographic characteristics of PPL are nonspecific, and PPL is often misdiagnosed as pancreatic cancer or pancreatic tuberculosis.…”