Primary Herpes simplex Virus Type 1 Gingivostomatitis During the Second and Third Trimester of Pregnancy: Foetal and Pregnancy Outcome

Pardo, Joseph; Yogev, Yariv; Ben-Haroush, Avraham; Hod, Moshe; Amir, Jacob

doi:10.1080/00365540410019354

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…A review of the literature of clinical outcomes of neonates born to mothers with documented primary HSV gingivostomatitis during pregnancy or at the time of delivery is limited to a few case reports, as summarized in Table 2 [1,[8][9][10][11]. In contrast to our case series, no adverse neonatal outcome was noted in the previously reported cases.…”

Section: Resultsmentioning

confidence: 68%

“…In addition, all previous case reports and series published up until now have indicated that primary maternal HSV-1 gingivostomatitis during pregnancy is not associated with adverse neonatal outcomes [1,[7][8][9][10]. However, given the identified adverse neonatal outcomes seen in our review, treating physicians should apply close monitoring practices and have a low threshold for prompt evaluation and treatment of these at-risk neonates.…”

Section: Discussionmentioning

confidence: 80%

“…pregnancy is not associated with adverse neonatal outcomes [1,[7][8][9][10]. Our case series is limited by lack of prospectively and systematically collected data and lack of information regarding the total number of cases of maternal primary HSV-1 gingivostomatitis (denominator) during the study period.…”

Section: Discussionmentioning

confidence: 99%

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Primary Maternal Herpes Simplex Virus-1 Gingivostomatitis During Pregnancy and Neonatal Herpes: Case Series and Literature Review

et al. 2012

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Background. Neonatal herpes simplex virus (HSV) is a serious, life-threatening infection that is usually acquired during birth from contact with infected maternal genital secretions. Primary maternal HSV gingivostomatitis is a rare occurrence during pregnancy, and HSV type 1 (HSV-1) neonatal disease after primary maternal HSV gingivostomatitis during pregnancy has not been reported in detail. Methods. We reviewed the medical records of neonates (28 days of age) with a confirmed diagnosis of neonatal HSV-1 at a single pediatric center from January 1981 to January 2010 to identify cases in which the mother had primary gingivostomatitis during pregnancy or at term. Results. Seven neonates whose mothers had primary HSV-1 gingivostomatitis during pregnancy were identified from a review of 48 neonates with laboratory-proven HSV-1 neonatal disease. Of the 7 women, 2 presented with symptoms of primary HSV-1 gingivostomatitis during the first trimester and 5 in the third trimester. Three of the neonates developed skin, eye, and mucous membrane disease, 2 developed central nervous system disease, and 2 developed disseminated disease. One of the neonates with disseminated HSV-1 disease died. Conclusions. Primary maternal HSV gingivostomatitis during pregnancy may lead to HSV-1 transmission to the neonate. Physicians caring for pregnant women should communicate the diagnosis of HSV gingivostomatitis to the neonate's primary provider to ensure proper surveillance, early evaluation, and prompt treatment.

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Section: Resultsmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 80%

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Primary Maternal Herpes Simplex Virus-1 Gingivostomatitis During Pregnancy and Neonatal Herpes: Case Series and Literature Review

et al. 2012

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“…Neonatal infection can be transmitted from the mother antepartum, but acquisition is most likely intrapartum during passage through the birth canal, in mothers with primary genital herpes infection, most often with type HSV-2 rather than HSV-1. A recent report of four cases of primary herpetic gingivostomatitis during the second and third trimester of pregnancy supports the notion that peripartum oral infection in the mother does not pose a significant risk for neonatal infection, but additional studies are needed to explore the extent of this type of risk [17].…”

Section: Primary Herpetic Gingivostomatitis and Recurrent Herpes Labimentioning

confidence: 90%

The diagnosis and management of oral herpes simplex infection

Birek

Ficarra²

2006

Curr Infect Dis Rep

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Acute herpetic gingivostomatitis and recurrent herpes labialis are the most common manifestations of infection with herpes simplex virus type 1 (HSV-1). In primary and recrudescent HSV-associated disease, the symptoms may range from subclinical to debilitating and life-threatening, depending on the host's immune responses or competence level. In this paper, the typical and atypical manifestations, and the current diagnostic and treatment options for localized, non-complicated oro-labial HSV infection are reviewed, with attention to cumulative evidence for the efficacy and safety of systemic antiviral agents. Some recent data on HSV-1 seroprevalence, viremia, and viral shedding are discussed in relation to disease transmission and global importance of herpesvirus disease.

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“…Herpes simplex virus (HSV) is a widespread pathogen that has diverse clinical manifestations ranging from mild to severe diseases leading to death, for example, cold sores, herpetic whitlow, gingivostomatitis, and neonatal herpes (Berkovich and Ressel, 1966;Crane and Lerner, 1978;Pardo et al, 2004;Slifer and Jennings, 2015). HSV belongs to the family Herpesviridae, subfamily Alphaherpesvirinae.…”

Section: Introductionmentioning

confidence: 99%

Impact of actin polymerization and filopodia formation on herpes simplex virus entry in epithelial, neuronal, and T lymphocyte cells

Sasivimolrattana,

Bhattarakosol

2023

Front. Cell. Infect. Microbiol.

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Herpes simplex virus type 1 (HSV-1) has been known as a common viral pathogen that can infect several parts of the body, leading to various clinical manifestations. According to this diverse manifestation, HSV-1 infection in many cell types was demonstrated. Besides the HSV-1 cell tropism, e.g., fibroblast, epithelial, mucosal cells, and neurons, HSV-1 infections can occur in human T lymphocyte cells, especially in activated T cells. In addition, several studies found that actin polymerization and filopodia formation support HSV-1 infection in diverse cell types. Hence, the goal of this review is to explore the mechanism of HSV-1 infection in various types of cells involving filopodia formation and highlight potential future directions for HSV-1 entry-related research. Moreover, this review covers several strategies for possible anti-HSV drugs focused on the entry step, offering insights into potential therapeutic interventions.

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Primary Herpes simplex Virus Type 1 Gingivostomatitis During the Second and Third Trimester of Pregnancy: Foetal and Pregnancy Outcome

Cited by 9 publications

References 6 publications

Primary Maternal Herpes Simplex Virus-1 Gingivostomatitis During Pregnancy and Neonatal Herpes: Case Series and Literature Review

Primary Maternal Herpes Simplex Virus-1 Gingivostomatitis During Pregnancy and Neonatal Herpes: Case Series and Literature Review

The diagnosis and management of oral herpes simplex infection

Impact of actin polymerization and filopodia formation on herpes simplex virus entry in epithelial, neuronal, and T lymphocyte cells

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