Primary High-grade Serous Carcinoma Arising in the Urethra or Urethral Diverticulum

Flynn, Ciaran; Oxley, Jon; McCullagh, Paul; McCluggage, W. Glenn

doi:10.1097/pgp.0b013e318253c71b

Cited by 10 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors [ 15 , 16 ] suggested that there is a clear association between clear cell adenocarcinoma and diverticula of the urethra and that CCAU is the most common malignancy arising from diverticula of the urethra. It has been stated whilst only 10% of carcinoma of the urethra is clear cell adenocarcinoma, one-third of such carcinomas originate in a diverticulum [ 15 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Venyo

2015

International Journal of Surgical Oncology

View full text Add to dashboard Cite

Background. Clear cell adenocarcinoma of the urethra (CCAU) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. Aims. To review the literature on CCAU. Methods. Various internet databases were used. Results/Literature Review. (i) CCAU occurs in adults and in women in the great majority of cases. (ii) It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii) It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv) It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v) CCAU is aggressive with low 5-year survival rates. (vi) There is no consensus opinion of treatment options that would improve the prognosis. Conclusions. Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

show abstract

Section: Literature Reviewmentioning

confidence: 99%

Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Venyo

2015

International Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…Tumors arising from urethral diverticulum represent only 0.002% of female malignancies [4]. While different studies have found substantial variance, the vast majority of primary urethral cancer in either sex and any race is squamous cell carcinoma as it represents almost twice as many cases as transitional and adenocarcinoma combined [2, 4, 5]. Clear cell adenocarcinoma, however, has a clear association with diverticula and is the most common malignancy arising from them [1, 4].…”

Section: Discussionmentioning

confidence: 99%

Primary Clear Cell Adenocarcinoma of a Urethral Diverticulum Treated with Multidisciplinary Robotic Anterior Pelvic Exenteration

Scantling

Ross

Jaffe

2013

Case Reports in Medicine

View full text Add to dashboard Cite

Primary urethral carcinoma is extremely rare and is marked by a variety of clinical symptoms. Primary carcinoma of a urethral diverticulum is still rarer and clear cell adenocarcinoma of the urethra is particularly uncommon (Swartz et al., 2006). Such infrequency has led to inadequate management guidance in the literature for a disease that is often late in presentation and carries substantial morbidity and mortality. This treatable but grave disease deserves definitive curative treatment. We present the first published instance in which it was treated with robotic anterior exenteration. In our case, a 47-year-old female was referred to the urology service for investigation of recurring urinary tract infections. During the workup, the patient was found to have an advanced clear cell urethral adenocarcinoma originating in a urethral diverticulum. We discuss the natural history of this condition, its consequences, and the first instance of its treatment using robotic anterior pelvic exenteration.

show abstract

“…However, these are rare lesions, representing only 0.002% of female malignancies, with *5% of female urethral carcinomas arising in a diverticulum. 69 Squamous cell carcinoma in situ has also arisen in a urethral diverticulum, in what the authors believed was the first reported case. 70 Due to the rarity of these lesions, there are no consensus protocols for therapy.…”

Section: Hellermentioning

confidence: 90%

“…This patient was also tumor free at 6 months. 69 A case of adenosquamous carcinoma arising in a villous adenoma in a 49-year-old woman has been reported. 54 The lesion presented as a rapidly growing painful mass with hematuria.…”

Section: Hellermentioning

confidence: 97%

Lesions of the Female Urethra: A Review

Heller

2015

Journal of Gynecologic Surgery

View full text Add to dashboard Cite

Objectives: The female urethra may become involved by a variety of conditions, which may be challenging to providers who treat women. Mass-like urethral lesions need to be distinguished from other lesions arising from the anterior (ventral) vagina. Methods: A literature review was conducted. A Medline search was used, using the terms urethral neoplasms, urethral diseases, and female. Results: Reported lesions of the urethra were reviewed. Many of these lesions can be mistaken for each other clinically. Conclusions: A review of the scope of urethral lesions is presented to assist in developing a differential diagnosis if a patient with a urethral lesion is encountered. For practitioners who care for women, this will encourage communication and consultation where appropriate. ( J GYNECOL SURG 31:189)

show abstract

Primary High-grade Serous Carcinoma Arising in the Urethra or Urethral Diverticulum

Cited by 10 publications

References 19 publications

Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Primary Clear Cell Adenocarcinoma of a Urethral Diverticulum Treated with Multidisciplinary Robotic Anterior Pelvic Exenteration

Lesions of the Female Urethra: A Review

Contact Info

Product

Resources

About