Primary Histiocytic Sarcoma of the Brain in an African Hedgehog (Atelerix albiventris)

Ogihara, Kikumi; Suzuki, Kaoru; Madarame, Hiroo

doi:10.1016/j.jcpa.2017.08.004

Cited by 16 publications

(14 citation statements)

References 18 publications

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“…Definitive diagnosis requires immunostaining [9]. Previous reports on HS in four-toed hedgehogs have also stated the utility of immunostaining including CD3 (as a T lymphocyte marker), CD20 (as a B lymphocyte marker) and Iba-1 (as a histiocytic marker) [9, 10]. This was also the case in our report, where HS was definitively diagnosed in all cases with anti-Iba-1 antibody immunostaining in addition to histological examinations.…”

supporting

confidence: 80%

Clinical management and outcome of four-toed hedgehogs (<i>Atelerix albiventris</i>) with histiocytic sarcoma

Koizumi¹,

Kondo

2019

J. Vet. Med. Sci.

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Four-toed hedgehogs presented bloody stool and loss of appetite. Integumental masses were observed in two of the four cases. Intraabdominal masses were observed on radiographs and ultrasonography in the remaining two cases. The masses were surgically removed from all four cases. All samples were histologically and immunohistochemically consistent with histiocytic sarcoma (HS). At the time of surgery, 3 of 4 cases had grossly recognized metastatic/disseminated lesions. Survival time was 48 days, 64 days, and 113 days, respectively, and the remaining case is currently alive (at Day 207). The present report describes the clinical management and outcome of hedgehogs that were diagnosed with HS.

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supporting

confidence: 80%

Clinical management and outcome of four-toed hedgehogs (<i>Atelerix albiventris</i>) with histiocytic sarcoma

Koizumi¹,

Kondo

2019

J. Vet. Med. Sci.

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“…Although histiocytic sarcoma is not a common tumor in African pygmy hedgehogs, several cases have been reported. 5,9,10 To our knowledge, lateral ventricular meningioma has not been reported previously in hedgehogs. Ventricular meningioma is rare in the veterinary field as well as in human patients.…”

mentioning

confidence: 79%

“…Although histiocytic sarcoma is not a common tumor in African pygmy hedgehogs, several cases have been reported. 5,9,10…”

mentioning

confidence: 99%

Wobbly hedgehog syndrome with disseminated histiocytic sarcoma and lateral ventricular meningioma in an African pygmy hedgehog

et al. 2020

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An 8-mo-old male African pygmy hedgehog was anorectic and ataxic; physical examination revealed tetraparesis and a gangrenous left hindlimb. Analgesic and supportive care were administered, but the animal died 3 d after presentation. Postmortem examination revealed a histiocytic sarcoma in a mesenteric lymph node with metastasis to several organs, multifocal vacuolation in the cerebral and cerebellar white matter, and a meningioma in the left lateral ventricle. We diagnosed wobbly hedgehog syndrome (WHS) with disseminated histiocytic sarcoma and lateral ventricular meningioma. Ventricular meningioma, a rare neoplasm in veterinary and human patients, has not been reported previously in hedgehogs, to our knowledge. The neurologic signs in our case were probably caused by the WHS-related vacuolar lesions and are consistent with those of reported WHS cases. Duration of illness was shorter than is typical of WHS cases, which might be related to the disseminated histiocytic sarcoma. Clinical relevance of the lateral ventricular meningioma was not evident because the ventricular mass was localized and not invasive.

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“…Hedgehogs are member of the order Eulipotyphla, nocturnal, solitary animals (19). The majority of the scientific and clinical-based knowledge about hedgehogs and their diseases come from North America (2,4,7,8,15,17) and Asia (13,14,16) but there are also European reports (9,11). In the last two decades, the number of scientific papers about diseases in pet hedgehogs increased.…”

Section: Artykuł Przeglądowy Reviewmentioning

confidence: 99%

Wobbly Hedgehog Syndrome (WHS): a review of knowledge and some practical suggestions about differential diagnosis

Ruszkowski¹

2020

Medycyna Weterynaryjna

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With increase in popularity of African pygmy hedgehogs kept as pets, veterinarians have a chance of getting more information about housing requirements and diseases of the species. Wobbly Hedgehog Syndrome (WHS) and various neoplasms have been detected frequently. Diagnostic procedures for differentiating nervous system diseases in hedgehogs are still being developed and the prevalence of different diseases seems to be depended on the genetic origin of an animal. The main goal of the article was to review of published data, compare the prevalence of diseases and pathological findings. There is still a need to establish good diagnostic schemes for a check-up examination to detect early stage of the diseases.

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Primary Histiocytic Sarcoma of the Brain in an African Hedgehog (Atelerix albiventris)

Cited by 16 publications

References 18 publications

Clinical management and outcome of four-toed hedgehogs (<i>Atelerix albiventris</i>) with histiocytic sarcoma

Clinical management and outcome of four-toed hedgehogs (<i>Atelerix albiventris</i>) with histiocytic sarcoma

Wobbly hedgehog syndrome with disseminated histiocytic sarcoma and lateral ventricular meningioma in an African pygmy hedgehog

Wobbly Hedgehog Syndrome (WHS): a review of knowledge and some practical suggestions about differential diagnosis

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