Primary hyperparathyroidism and metastatic carcinoma within parathyroid gland

Venkatraman, Lakshmi; Kalangutkar, A; Russell, C. F. J.

doi:10.1136/jcp.2005.035352

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…At autopsy at least 70% of their parathyroid glandular tissue was replaced by metastatic tumor. Other than these exceptional cases, patients with metastases to the parathyroid glands are almost invariably asymptomatic with the abnormal gland(s) discovered at the time of postmortem examination [59,60].…”

Section: Parathyroid Glandsmentioning

confidence: 99%

Metastases to the Head and Neck: An Overview

Barnes

2009

Head and Neck Pathol

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Section: Parathyroid Glandsmentioning

confidence: 99%

Metastases to the Head and Neck: An Overview

Barnes

2009

Head and Neck Pathol

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“…Gattuso et al in a letter to the editor mentioned two cases of metastatic bronchogenic adenocarcinoma into parathyroid glands but further details were not given (5). Venkatraman et al reported a case 75-year-old woman with a primary hyperparathyroidism (6). Her postoperative pathological evaluation was consistent with findings of metastatic bronchogenic adenocarcinoma in one of two hyperplastic parathyroid glands and in one suspicious submandibular lymph node that was also removed.…”

Section: Discussionmentioning

confidence: 60%

Neuroendocrine Thymic Carcinoma Metastatic to the Parathyroid Gland that was Reimplanted into the Forearm in Patient with Multiple Endocrine Neoplasia Type 1 Syndrome: A Challenging Management Dilemma

et al. 2013

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“…Furthermore, as parathyroid involvement occurred in patients with extensive metastases in other organs, it has been suggested that this event may represent a symptom of late-stage cancers (18). In clinical series, the metastatic involvement of the parathyroid gland occurred more commonly as a solitary lesion without systemic dissemination (24–27). The previously reported cases of metastatic carcinoma affecting the parathyroid gland originated from the breast, lung, skin (malignant melanoma), liver and hemolymphatic system (chronic lymphocytic leukemia) (14–27).…”

Section: Discussionmentioning

confidence: 99%

“…The metastatic involvement of the parathyroid gland may be associated with altered parathyroid function, including hypoparathyroidism (17,19) and hyperparathyroidism (24–27). In certain circumstances, metastasis to the parathyroid gland has been proposed as an alternative mechanism of ‘malignant hypercalcemia’, occurring in a peculiar subgroup of patients with widespread metastatic malignant neoplasm (22).…”

Section: Discussionmentioning

confidence: 99%

Metastasis of renal cell carcinoma to the parathyroid gland 16 years after radical nephrectomy: A case report

et al. 2016

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Renal cell carcinoma (RCC) has a high metastatic potential, and most commonly metastasizes via the bloodstream, although lymphatic metastases also occur. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after a number of years, is common. The occurrence of RCC metastasis to the head and neck region is uncommon, and occurs primarily in the thyroid gland and in patients with widespread dissemination. Involvement of the parathyroid gland in metastatic carcinoma is extremely rare. In the present report, a case of metastasis confined to the parathyroid gland is described, likely with intrathyroidal localization, arising from a RCC that occurred 16 years after nephrectomy. A 66-year-old man was referred to the Department of Surgery of the University Hospital of Pisa (Pisa, Italy) with a preoperative fine-needle aspiration diagnosis of a follicular lesion in the context of nodular goiter of the thyroid gland. The previous medical history of the patient included a right nephrectomy for the treatment of clear cell RCC in February 1997. No other distant metastases were identified as of the latest follow-up in March 2014. At the time of thyroid surgery, the thyroid and parathyroid function tests were normal. The gross appearance of the surgical specimen was a multinodular goiter with a solid nodule measuring 33 mm on the left lobe of the thyroid gland. Microscopic examination revealed a completely encapsulated lesion consisting of clear cells arranged in a solid pattern and intermixed with fragments of parathyroid tissue. Following immunohistochemical examination, the clear cell lesion was negative for thyroid transcription factor-1 and thyroglobulin and strongly positive for epithelial membrane antigen, cluster of differentiation 10 and vimentin. To the best of our knowledge, this is the second case of metastasis to the parathyroid gland from a RCC reported in the literature.

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Primary hyperparathyroidism and metastatic carcinoma within parathyroid gland

Cited by 16 publications

References 11 publications

Metastases to the Head and Neck: An Overview

Metastases to the Head and Neck: An Overview

Neuroendocrine Thymic Carcinoma Metastatic to the Parathyroid Gland that was Reimplanted into the Forearm in Patient with Multiple Endocrine Neoplasia Type 1 Syndrome: A Challenging Management Dilemma

Metastasis of renal cell carcinoma to the parathyroid gland 16 years after radical nephrectomy: A case report

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