Primary Hyperparathyroidism Associated with Multiple Myeloma.

Abstract

A 73-year-old womanwas diagnosed as primary hyperparathyroidism. Hypercalcemia recurred after parathyroidectomy, though serum calcium concentration temporarily resumed to normal. Hypercalcemiawas eventually shownto be due to multiple myeloma.In spite of the frequent association of hypercalcemia with malignant disease and the relative frequency of primary hyperparathyroidism as a cause ofhypercalcemia, primary hyperparathyroidism accompanied by multiple myelomahas been considered in only a limited number of reports. Here, the cases in the literature are reviewed and discussed. (Internal Medicine 34: 988-991, 1995)

Prevalence of Monoclonal Gammopathy in Patients With Primary Hyperparathyroidism

“…Therefore, the association between the 2 disorders is still controversial. [4][5][6][7][8][9][10][11] This prompted us to prospectively evaluate the prevalence of monoclonal gammopathies in patients with surgically proved PHPT.…”

A Case of Primary Hyperparathyroidism Accompanying Multiple Myeloma.

“…Either diagnosis does not exclude the other, and inadequate intervention may result in partially increased morbidity or mortality. Although the association of MM with I°HPT has been reported previously in 12 case reports (adenoma: 10 cases, hyperplasia:1 case) [1][2][3][4][5][6][7][8][9][10][11][12], only one case of this combination has been reported in Japan [12]. The mechanisms leading to the onset of I°HPT and MM in this patient are unclear.…”

Medical Management of Primary Hyperparathyroidism with Concommitant Multiple Myeloma

“…Parathyriodectomy was necessary in 13 cases to achieve the eucalcemic state, and this study concluded that surgical treatment is indicated in these synchronous conditions to correct hypercalcemia (2).…”

“…However, the occurrence of these two relatively common conditions in the same patient is rare (1) and has been reported only 17 times in the literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) d g l a n d , a h e t e r o g e n e o u s r o u n d ma s s t h a t me a s u r e s 1 . 1 × 1 .…”