Primary hyperparathyroidism: hormonal profile and risk of complications

Gatu, Alina-Andreea; Velicescu, Cristian; Preda, Cristina; Mogoş, Voichiţa; Vulpoi, Carmen; Mogos, Simona; Zaharia, Valentin; Aancute, Adrian; Brănișteanu, Dumitru

doi:10.1530/endoabs.49.ep213

Cited by 2 publications

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“…Primary hyperparathyroidism (pHPTH) is caused by the excessive parathyroid hormone (PTH) leading to deleterious impact on calcium and bone metabolism (1,2). pHPTH has a high incidence in the general population and the main cause is the presence of a solitary parathyroid adenoma (3,4), therefore patients can be cured by minimally invasive parathyroidectomy in roughly 90% of cases after previous preoperative localization of the diseased parathyroid gland (5).…”

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confidence: 99%

The Volume of Solitary Parathyroid Adenoma is Related to Preoperative PTH and 250H-D3, but Not to Calcium Levels

et al. 2017

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Purpose. To correlate the volume of parathyroid adenomas with the hormonal and metabolic profile at patients diagnosed with primary hyperparathyroidism (pHPTH). Patients and Methods. Cross-sectional multicentric study, enrolling 52 patients with pHPTH from two medical institutions. Serum calcium and PTH were evaluated in all patients before surgery, whereas 25OHD3 was measured only in the 33 patients recruited form one medical unit. The volume of parathyroid adenoma was measured by using the formula of a rotating ellipsoid. Results. We observed a significant correlation of the volume of parathyroid adenomas with PTH at patients from the two units and in the whole group (p < 0.0001), but not with serum calcium (p = 0.494). Twenty-five out of the 33 patients at whom 25OHD3 was measured had levels in the range of deficiency. 25OHD3 was not correlated with PTH or calcium levels, but was negatively correlated to the adenoma volume and positively to the PTH/volume ratio (p = 0.041 and p = 0.048, respectively). Conclusions. The volume of parathyroid adenoma seems to be related to preoperative PTH and 25OHD3, but not to calcium level. Vitamin D deficiency is frequently found at patients with pHPTH and may contribute to particular disease profiles, including larger parathyroid adenomas.

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confidence: 99%

The Volume of Solitary Parathyroid Adenoma is Related to Preoperative PTH and 250H-D3, but Not to Calcium Levels

et al. 2017

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“…In the evolution of chronic pancreatitis, secretory capacity of the pancreas and, implicitly, intraluminal digestion decrease. In chronic pancreatitis of alcoholic etiology, malabsorption usually does not occur earlier than ten years from the beginning of clinical symptomatology [1,2]. As a result of the normal back up of pancreas secretory capacity, the inflammatory process must destroy more than 90-95% of the secretory parenchyma before malabsorption occurs.…”

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Enzymatic Treatment of Chronic Pancreatitis

Grigorovici¹,

Andronic²,

Hînganu³

et al. 2019

Rev. Chim.

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The treatment of chronic pancreatitis consists of conservative and surgical treatment. The current development of interventional endoscopy techniques links the two above-mentioned treatments, offering less invasive solutions. In the treatment of chronic pancreatitis, a progressive approach is needed. Establishing any type of treatment is useless if the patient does not follow the recommendation to mainatin a proper diet. The study was conducted on a group of 61 patientshospitalized and operated for chronic forms of pancreatitis. Pancreatic insufficiency due to chronic pancreatitis is not a simple enzymatic deficiency, but an interactive complex of secretory, motor and endocrine functional disorders. Therefore, developing drug therapy will require not only the simple administration of enzymes in the intestine but also the restoration of the integrity of disruptive digestive functions.

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Primary hyperparathyroidism: hormonal profile and risk of complications

Cited by 2 publications

References 0 publications

The Volume of Solitary Parathyroid Adenoma is Related to Preoperative PTH and 250H-D3, but Not to Calcium Levels

The Volume of Solitary Parathyroid Adenoma is Related to Preoperative PTH and 250H-D3, but Not to Calcium Levels

Enzymatic Treatment of Chronic Pancreatitis

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