Primary hyperparathyroidism in adolescents: the same but different

Pashtan, Itai; Grogan, Raymon H.; Kaplan, Sharone P.; Devon, Karen; Angelos, Peter; Liu, Donald; Kaplan, Edwin L.

doi:10.1007/s00383-012-3222-3

Cited by 26 publications

(30 citation statements)

References 10 publications

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“…This was much more common in series describing children with familial hyperparathyroidism [2,3,17] . Children with sporadic PHPT are almost always cured by the first operation [4,6,9,17] . Postoperative symptomatic hypocalcaemia was the commonest complication reported in 20-47% of children.…”

Section: Surgery For Phptmentioning

confidence: 99%

“…IOPTH monitoring is routinely used by 68% of the members of IAES [43] . Evidence of IOPTH in children is very limited and has been described in only 3 studies [4,9,17] . Durkin et al [4] used it in conjunction with radio-guided parathyroidectomy and Pashtan et al [9] with BNE.…”

Section: Intraoperative Techniques Aiding Localisation and Confirmatimentioning

confidence: 99%

“…Evidence of IOPTH in children is very limited and has been described in only 3 studies [4,9,17] . Durkin et al [4] used it in conjunction with radio-guided parathyroidectomy and Pashtan et al [9] with BNE. Our group was the first to report the successful use of IOPTH monitoring in children undergoing mini-incision MIP.…”

Section: Intraoperative Techniques Aiding Localisation and Confirmatimentioning

confidence: 99%

“…In children, MIBI scanning is used frequently and has a sensitivity of 60-90% [5,6,9] . Combined ultrasound and MIBI scanning has an overall sensitivity of 73% [3] and 95% [28,29] in detecting solitary adenomas.…”

Section: Investigationsmentioning

confidence: 99%

“…In adults it is a common condition and much is known about its epidemiology, clinical course, accuracy of imaging, and outcomes of surgical treatment. In contrast, PHPT in children is very rare, and such information is sparse as only about 200 cases have been described in the world literature [1][2][3][4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

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Aetiology, Diagnosis and Surgical Treatment of Primary Hyperparathyroidism in Children: New Trends

Alagaratnam

Kurzawinski²

2015

Horm Res Paediatr

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Primary hyperparathyroidism (PHPT) in children is a rare disorder with sharp contrasts in its presentation and aetiology compared with the disease process in adults. This review outlines the current literature, which is limited to about 200 cases, with reference to the aetiology, clinical features, outcomes of investigations, and surgery in children affected by PHPT. Familial conditions account for almost half of all cases of PHPT in children, suggesting that routine genetic testing would be appropriate. Neonatal severe hyperparathyroidism requires urgent medical attention, and performing total parathyroidectomies offers cure, though conservative management is successful in selected cases. Familial hyperparathyroidism in older children can be caused by conditions such as multiple endocrine neoplasia types 1 and 2a, hyperparathyroidism-jaw tumour syndrome and familial hyperparathyroidism. The role of surgery for this group is discussed. The use of ultrasound and MIBI (<sup>99m</sup>Tc-methoxyisobutylnitrile) scanning appears to accurately localise solitary adenomas in sporadic PHPT, thereby supporting the role of minimally invasive parathyroidectomy in children.

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Section: Surgery For Phptmentioning

confidence: 99%

Section: Intraoperative Techniques Aiding Localisation and Confirmatimentioning

confidence: 99%

Section: Intraoperative Techniques Aiding Localisation and Confirmatimentioning

confidence: 99%

Section: Investigationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aetiology, Diagnosis and Surgical Treatment of Primary Hyperparathyroidism in Children: New Trends

Alagaratnam

Kurzawinski²

2015

Horm Res Paediatr

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Hypercalcemic Crisis

Carneiro-Pla

Koeberle-Wuehrer

Solórzano

2021

Endocrine Surgery Comprehensive Board Exam Guide

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Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus

et al. 2016

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The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH). It is most commonly seen after the age of 50 years, with women predominating by three to fourfold. In countries with routine multichannel screening, PHPT is identified earlier and may be asymptomatic. Where biochemical testing is not routine, PHPT is more likely to present with skeletal complications, or nephrolithiasis. Parathyroidectomy (PTx) is indicated for those with symptomatic disease. For asymptomatic patients, recent guidelines have recommended criteria for surgery, however PTx can also be considered in those who do not meet criteria, and prefer surgery. Non-surgical therapies are available when surgery is not appropriate. This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized.

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Primary hyperparathyroidism in adolescents: the same but different

Abstract: Adolescents with primary hyperparathyroidism typically have more severe disease than adults. Contrary to popular belief, most adolescents have single gland disease and not hyperplasia associated with a genetic disorder.

Cited by 26 publications

References 10 publications

Aetiology, Diagnosis and Surgical Treatment of Primary Hyperparathyroidism in Children: New Trends

Aetiology, Diagnosis and Surgical Treatment of Primary Hyperparathyroidism in Children: New Trends

Hypercalcemic Crisis

Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus

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