PRIMARY HYPERPARATHYROIDISM IN CHILDREN: <i>Brief Review of the Literature and a Case Report</i>

Bjernulf, A.; Hall, Kerstin; Sjögren, I; Werner, Ivar

doi:10.1111/j.1651-2227.1970.tb09000.x

Cited by 43 publications

(21 citation statements)

References 27 publications

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“…A consistent finding in most series, including ours, is the predominance of males among children or adolescents with PHPT (Bjernulf et al, 1970;Mannix, 1975;Girard et al, 1982;Rapaport et al, 1986); only a single series showed female predisposition (Allo et al, 1982). The gender distribution is less clearly defined among the young adult patients: our experience shows the usual female preponderance as observed in elderly patients (Heath et al, 1980), whereas male predominance was noted in the only other reported series (Allo et al, 1982).…”

Section: Discussionsupporting

confidence: 80%

“…Hypertension was less frequently noted in other series, ranging from 0 to 17% (Bjernulf et al, 1970;Allo et al, 1982;Rapaport et al, 1986;Lawson et al, 1996). Hypertension was less frequently noted in other series, ranging from 0 to 17% (Bjernulf et al, 1970;Allo et al, 1982;Rapaport et al, 1986;Lawson et al, 1996).…”

Section: Discussionmentioning

confidence: 62%

“…Among the first 43 paediatric patients reported in the literature: 24 (56%) had complaints of fatigue, weakness, anorexia, constipation or vomiting; 16 (37%) had bone and joint symptoms or fractures; 12 (28%) had polydipsia and polyuria; and 11 (26%) had renal calculi (Bjernulf et al, 1970). The earlier reports suggested a lower incidence of renal calculi in children as compared to adults with PHPT, as documented in only 26% of the first 43 reported cases (Bjernulf et al, 1970). Despite the high prevalence of renal and osseous complications in one series, half of the patients presented with irritability, weight loss, nausea or vomiting, and growth retardation (Rapaport et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

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Clinical profile of primary hyperparathyroidism in adolescents and young adults

Loh

Duh

Shoback

et al. 1998

Clinical Endocrinology

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We found a high incidence of multiglandular disease and relatively non-specific symptomatology in our adolescent and young adult patients with primary hyperparathyroidism. In view of the heterogeneous clinical expression noted in young patients, one should consider primary hyperparathyroidism in the differential diagnosis of unexplained non-specific complaints, and perform serum calcium estimations more readily in these subjects. Our experience suggests that primary hyperparathyroidism can be a serious disease with significant morbidity if left untreated, whereas parathyroidectomy provides successful results.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Clinical profile of primary hyperparathyroidism in adolescents and young adults

Loh

Duh

Shoback

et al. 1998

Clinical Endocrinology

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“…Bei Kindern und Jugendlichen wurde früher eher die Assoziation mit familiären multiplen endokrinen Neoplasiesyndromen (MEN) als Ursache angenommen. Im Gegensatz zum Erwachsenenalter wird im Kindesalter das männliche Geschlecht bevorzugt betroffen [5,10,12]. Im Gegensatz zum Erwachsenenalter wird im Kindesalter das männliche Geschlecht bevorzugt betroffen [5,10,12].…”

Section: Pri Märer Hyperparathyroidismus (Phpt)unclassified

Akute Pankreatitis

Kronberger

Havranek

Wiesbauer

et al. 2001

Monatsschrift Kinderheilkunde

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ZusammenfassungFragestellung. Primärer Hyperparathyroidismus (pHPT) im Kindes-und Jugendalter ist eine äußerst seltene Erkrankung, weshalb die Diagnose häufig verzögert gestellt wird. Methode. Es wird über einen 13-jährigen Jungen berichten, welcher zur Klärung einer seit 9 Monaten bestehenden Übelkeit sowie eines Gewichtsverlusts von 9 kg zur stationären Aufnahme an unsere Abteilung kam.Es wurden ein Epithelkörperchenadenom als Ursache eines primären Hyperparathyroidismus sowie eine akute Pankreatitis im Rahmen einer hyperkalzämischen Krise diagnostiziert. Ergebnisse. Nach klinischer Stabilisierung wurde die Raumforderung operativ entfernt. Der postoperative Verlauf gestaltete sich komplikationslos, die Parathormonwerte sowie der Kalziumspiegel normalisierten sich.Innerhalb von 3 Monaten erreichte der Patient wieder sein Ausgangsgewicht. Schlussfolgerungen. Symptome wie Hypertonie, Kopfschmerzen, Bauchschmerzen, Anorexie, Gewichtsverlust, aber auch Nierensteine sollten im Rahmen der Abklärung immer auch an einen pHPT denken lassen.Eine Koinzidenz von pHPT und Pankreatitis ist ausgesprochen selten und dürfte laut Literatur am ehesten auf den erhöhten Serumkalziumspiegel im Rahmen eines bereits fortgeschrittenen pHPT zurückzuführen sein. SchlüsselwörterPrimärer Hyperparathyroidismus · Kindheit · Akute Pankreatitis · Hyperkalzämie AbstractBackground. Primary hyperparathyroidism (pHPT) in childhood and adolescence is a rare disease.Therefore diagnosis often is delayed. Methods. We report on a 13 year old boy, who sufferd from nausea, abdominal pain and weight loss for 9 months.We diagnosed an adenoma of the parathyroid gland and an acute pancreatitis in the course of a hypercalcemic crisis.

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“…Hypercalcemia is less common in children and adolescents than in adults, and most cases are attributable to primary hyperparathyroidism (1)(2)(3). When a diagnosis of primary hyperparathyroidism is established, its etiology is an important guide to therapy.…”

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confidence: 99%

Persistent Hypercalcemia After Parathyroidectomy in an Adolescent and Effect of Treatment With Cinacalcet HCl

Henrich¹,

Rogol

D'Amour

et al. 2006

Clinical Chemistry

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Background: Hyperparathyroidism is uncommon in adolescence and is more likely to persist after parathyroidectomy than in adults. Cinacalcet HCl is a new calcimimetic that has been used successfully for the treatment of primary and secondary hyperparathyroidism in adults, but its use in adolescents has not been reported. Case: A 16 year-old male presented with hypercalcemia that had persisted for 1.5 years after parathyroidectomy for primary hyperparathyroidism. Parathyroid hormone (PTH) concentrations were nonsupressed despite a mean (SD) serum calcium concentration of 2.82 (0.06) mmol/L. Treatment with cinacalcet HCl was initiated and a pharmacodynamic profile was obtained for serum calcium, phosphorus, and PTH. Cinacalcet HCl normalized serum calcium. The changes in PTH were assay dependent. Issues: We use this case conference to review the evaluation of hypercalcemia in adolescents, examine the changes in relevant laboratory results during treatment with cinacalcet HCl, and discuss differences among assays for PTH. Conclusions: Interpretation of PTH results in patients treated with cinacalcet HCl requires consideration of the pharmacodynamic effects of the drug and the nature of the PTH assay.

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PRIMARY HYPERPARATHYROIDISM IN CHILDREN: Brief Review of the Literature and a Case Report

Cited by 43 publications

References 27 publications

Clinical profile of primary hyperparathyroidism in adolescents and young adults

Clinical profile of primary hyperparathyroidism in adolescents and young adults

Akute Pankreatitis

Persistent Hypercalcemia After Parathyroidectomy in an Adolescent and Effect of Treatment With Cinacalcet HCl

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