Primary Hyperparathyroidism: Is There an Increased Prevalence of Renal Stone Disease?

Abstract

Our results showed a fourfold increased prevalence of asymptomatic renal stone disease in patients with surgically proven primary hyperparathyroidism compared with subjects not affected by the disorder. The National Institutes of Health consensus conference on asymptomatic primary hyperparathyroidism recommended that patients with renal stone disease undergo parathyroid surgery. These patients should undergo surgery even if they have minimal or no elevation of the total serum calcium value and no other metabolic manifestations of hyperparathyroidism. The finding of nephrocalcinosis or nephrolithiasis is, therefore, a significant finding in evaluating patients for parathyroid surgery. Routine imaging of the kidneys is necessary when primary hyperparathyroidism is documented.

Renal stones and calcifications in patients with primary hyperparathyroidism: associations with biochemical variables

“…They excluded patients with moderate-severe diarrhoea syndrome and impaired renal function. Our findings are also in contrast to the prevalence of 7% found by routine renal sonography by Suh et al (18). They retrospectively investigated 271 with surgically proven parathyroid adenomas.…”

“…It also points to the importance of including previous stones in the evaluation of risk of stones in PHPT. Our prevalence of renal calcification was higher than the prevalence reported based on sonography (18). This may suggest that a CT scan in a cross-sectional setting is more sensitive than sonography in the diagnosis of nephrocalcinosis and should be used for the routine examination of the patients.…”

“…In accordance, PHPT is a known risk factor for renal stone formation, which is observed with an estimated prevalence of 7-40% (17,18). Furthermore, among patients presenting with renal stones, the prevalence of concurrent PHPT is around 2% (19).…”

“…This may suggest that a CT scan in a cross-sectional setting is more sensitive than sonography in the diagnosis of nephrocalcinosis and should be used for the routine examination of the patients. It is difficult to conclude on the prevalence of renal stones in PHPT as the reports vary from 7% (18) to 60% (17). The wide range in reported prevalence of stones is difficult to explain but may be based on the differences between studies in study populations, assessment of previous clinical stones and methodology used to identify calcifications and persistent stones.…”

Nephrolithiasis in primary hyperparathyroidism: a contemporary look

“…Почечная недостаточность является одним из наи-более тяжелых и малообратимых осложнений и связана с более выраженными клиническими проявлениями, повышением риска смерти, увеличением распростра-ненности артериальной гипертензии [22][23][24][25]. По дан-ным Tassone F. и соавт., снижение СКФ до ХБП 3-й стадии диагностируется у 17% из 294 пациентов с ПГПТ, при этом почти половина из них имеют мяг-кую форму заболевания [26].…”