Primary<i>Histoplasma capsulatum</i>Enterocolitis Mimicking Peptic and Inflammatory Bowel Disease

Nakshabendi, Rahman; Berry, Andrew C.; Torres-Miranda, Daisy; LaBarbera, Francis D.; Kanar, Ozdemir; Nakshabandi, Ahmad; Nakshabendi, Imad

doi:10.1155/2016/7139573

Cited by 3 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analysis of the 123 well-documented cases showed the clinical presentation of GIH was often non-specific and mimicked several other gastrointestinal conditions and pathologies, including abdominal tuberculosis (n = 3, 2.4%) [ 85 , 96 , 102 ], GIH and TB coinfection was reported in four [3.3%] cases [ 78 , 87 , 96 , 98 ], inflammatory bowel disease (n = 9, 7.3%) [ 21 , 33 , 40 , 52 , 69 , 75 , 89 , 105 , 107 ], intestinal obstruction (n = 15, 12.2%) [ 15 , 21 , 39 , 50 , 57 , 64 , 71 , 77 , 81 , 89 , 95 , 102 , 103 , 104 , 117 ], abdominal malignancy (n = 9, 7.3%) [ 14 , 16 , 31 , 80 , 83 , 101 , 102 , 108 , 112 ], GI bleeding (n = 29, 23.6%) [ 17 , 18 , 25 , 26 , 27 , 29 , 30 , 31 , 33 , 37 , 41 , 44 , 53 , 56 ,…”

Section: Resultsmentioning

confidence: 99%

“…The non-specific signs and symptoms of GIH, as highlighted in this review, include but are not limited to abdominal pain [ 12 , 18 , 19 , 20 , 20 , 21 , 22 , 25 , 27 , 31 , 33 , 35 , 36 , 37 , 38 , 40 , 41 , 43 , 45 , 47 , 50 , 51 , 54 ], diarrhoea [ 12 , 17 , 19 , 21 , 22 , 36 , 37 , 38 , 39 , 40 , 43 , 53 , 68 , 74 , 75 , 103 , 104 , 105 , 106 ], fever [ 12 , 13 , 17 , 19 , 26 , 27 , 28 , 30 , 31 , 33 , 35 ], weight loss [ 13 , 31 , 77 , 79 , 84 , …”

Section: Discussionmentioning

confidence: 99%

“…Oesophageal histoplasmosis is linked to the early phase of histoplasmosis infection predominantly due to adjoining mediastinal adenitis [ 6 , 75 ] or later from progressive scarring in fibrosing mediastinitis or disseminated disease [ 6 , 82 ]. Endoscopic findings in GIH involving the oesophagus could be erythema or local inflammation [ 40 , 42 , 56 , 58 , 105 ], polyps [ 13 ] and ulcerations [ 20 , 84 , 100 , 104 , 121 ]. During the period under review, twelve patients [ 13 , 20 , 40 , 42 , 48 , 56 , 58 , 84 , 100 , 104 , 105 , 121 ] presented with GIH with oesophageal involvement and five were immunocompromised [ 13 , 40 , 100 , 104 , 121 ] with HIV infection.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

View full text Add to dashboard Cite

Gastrointestinal histoplasmosis (GIH) is infrequently described in people without underlying HIV infection. We aimed to compare the clinical presentation of GIH in people with and without HIV infection. We conducted a literature search of published cases of GIH from 2001–2021 and found 212 cases. Of these, 142 (67.0%) were male, and 124 (58.5%) had HIV infection. Most cases were from North America (n = 88, 41.5%) and South America (n = 79, 37.3%). Of the 212 cases, 123 (58.0%) were included in both clinical and pathological analyses. The remainder were excluded as details about clinical and pathological findings were not available. Of the 123 cases, 41 had HIV infection while 82 were without HIV infection. The diagnosis was predominantly by histopathology (n = 109, 88.6%). A significant proportion of people with HIV infection had abdominal pain as the most predominant symptom of GIH compared to those without HIV infection (65.9% versus 41.9%, p < 0.05). The colon was the most affected site with a slightly higher proportion in those with HIV infection compared with cases without HIV infection (46.3% versus 42.7%). The commonest pathologic findings were caecal and ileal ulcers. Caecal ulcers were significantly more frequent in cases with HIV infection compared to those without HIV (32.1% versus 7.1%, p < 0.05). Despite being more common in people with HIV infection, GIH also affects people without HIV infection with similar clinical presentations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…However in symptomatic patients, the most common presentation is fever, bloody diarrhea, abdominal pain, hepatosplenomegaly and lymphadenopathy. [5,20] In our case too, abdominal pain, lymphadenopathy and possibly hepato-splenomegaly (abdominal distension) were present. However our patient primarily presented with obstructive features (vomiting, constipation).…”

Section: Discussionmentioning

confidence: 48%

“…These areas serve as potential entry sites for the organisms, which are small, ovoid, usually intracellular yeast forms in macrophages, with small buds at the more pointed pole. [5,3] Appropriate treatment with antifungal therapy definitely improves outcomes; nevertheless, zygomycosis and aspergillosis cases still have high mortality rates. [6] Rachana A et al showed only inflammatory exudate.…”

Section: Introductionmentioning

confidence: 99%

Fungal Infections Masquerading as Gastrointestinal Tract Malignancies – A Series of Three Cases

Chaturvedi¹,

Baste²,

Karegar³

et al. 2021

Ann of Pathol and Lab Med

View full text Add to dashboard Cite

Fungal infections of the gastrointestinal tract (GIT) are not rare, but get missed due to their misleading clinical features. Here we report three GIT fungal infections at different locations with varied symptoms. We received surgical resection specimens with the clinical suspicion of malignancy for all. The first was a case of Aspergillosis, at an uncommon site, esophageal, in a 60year diabetic male with a suspicion of carcinoma in view of presence of dysphagia and a stricture on CT. The second was a 60-year male, a case of stomach Zygomycosis with no definite immunosuppression, who presented with an intra-operative suspicion of malignancy, and showed fungal angio-invasion and ischemic perforation. Third was a 32year immunocompetent male, a case of GI histoplasmosis with an uncommon presentation, showing obstructive symptoms due to an ileocaecal mass with a clinical suspicion of TB/malignancy. Thus, a high index of suspicion for fungal a etiology in GIT is essential, because misdiagnosis can lead to a radical surgery. Timely treatment with appropriate antifungal therapy is crucial as high mortality is associated with certain fungi.

show abstract

Histoplasmosis confinada a colon en una paciente con lupus eritematoso sistémico

Chicangana-Túquerres,

Salazar-Acosta,

Osorio-Gómez

et al. 2023

Acta Med Col

View full text Add to dashboard Cite

La histoplasmosis es una micosis sistémica causada por la inhalación de microconidias del hongo dimórfico Histoplasma capsulatum. La forma de progresión extrapulmonar de esta entidad es frecuente en pacientes inmunocomprometidos, siendo el sistema gastrointestinal uno de los principales sitios anatómicos de diseminación; sin embargo, es muy inusual la manifestación de histoplasmosis gastrointestinal aislada sin un foco pulmonar inicial. Se presenta el caso de una paciente de 24 años de edad con antecedente de lupus eritematoso sistémico (LES) de difícil manejo que requirió altas dosis de corticosteroides durante varios meses, quien debuta con cuadro agudo de colitis ulcerada por Histoplasma capsulatum sin compromiso de otro órgano o sitio anatómico, por lo que se concluye como un caso de histoplasmosis confinada a colon, el cual epresentó un reto clínico para el control de la infección fúngica en el contexto de patología autoinmune.

show abstract

PrimaryHistoplasma capsulatumEnterocolitis Mimicking Peptic and Inflammatory Bowel Disease

Cited by 3 publications

References 5 publications

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Fungal Infections Masquerading as Gastrointestinal Tract Malignancies – A Series of Three Cases

Histoplasmosis confinada a colon en una paciente con lupus eritematoso sistémico

Contact Info

Product

Resources

About