Primary immune deficiency among patients with recurrent infections

Silva, Rajiva de; Gunawardena, S.; Wickremesinghe, G; Ranasinghe, Beatrice; Namasivayam, Y

doi:10.4038/cmj.v52i3.964

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although these guidelines are so applicable and useful in the diagnosis of PID in both children and adults, further development and refinement of the suggested warning signs show that reliance on these signs cannot identify all patients with PID (3,15,16). Since early diagnosis and treatment of PID are very important (18,19), it is necessary to know the proportional rate of PID among the children suffering from recurrent infections (20). However, this rate varies among different settings and different ethnicities.…”

Section: Introductionmentioning

confidence: 99%

“…Although there are some important reports on registries of PID patients in Iran and other countries, there is no clinical study on children with recurrent infectious diseases, to classify them into diagnostic subgroups and show the applicability of a stepwise approach to the recurrent infection. Furthermore, there are only a few similar articles in this field all over the world (16,20,23). This survey was designed to identify the frequency of underlying primary immunodeficiency among pediatric patients with recurrent infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic investigation for underlying causes of recurrent infections in children: surveillance of primary immunodeficiency

Yousefzadegan

Tavakol²,

Abolhassani

et al. 2017

Eur Ann Allergy Clin Immunol

View full text Add to dashboard Cite

Recurrent infections seem to be a common complaint in children who are referred to general practitioners and pediatricians offices. Detection of primary immunodeficiencies (PID) etiology is very important for achieving appropriate diagnosis and treatment of these patients. The absence of appropriate treatment could lead to subsequent complications, in a hospital inpatient and/or outpatient settings. This study was performed in a group of children with recurrent infections to identify patients with underlying PID. A cross-sectional study was designed to evaluate the final clinical diagnosis obtained in 100 pediatric patients with a history of recurrent infections referred to Children s Medical Center, Tehran, Iran, during one year (2011-2012). History taking and physical examination, complementary laboratory tests including immunological investigations were done to confirm the main causes of disease according to our previously published stepwise approach to recurrent infections. Among all studied patients, 21% (11 males and 10 females) were diagnosed to have PID. Parental consanguinity (p = 0.001) and soft tissue infections (p = 0.004) were significantly higher in PID group, comparing to other causes of recurrent infections. Gender and location of infections were also linked to the type of PID including antibody deficiency, combined immunodeficiency and phagocytosis disorders. The real rate of PID as a cause of recurrent infection appears to be much higher than what is generally considered in a se-lected group of pediatric patients; so, following the suggested stepwise guideline can im-prove timely diagnosis and appropriate treatment of these patients.

show abstract