Primary Intestinal Hodgkin’s Lymphoma: An Uncommon Presentation

Sharma, Shruti; Rana, Safia; Kapur, Sujala; Jairajpuri, Zeeba S

doi:10.4103/0974-2727.119866

Cited by 9 publications

(11 citation statements)

References 8 publications

(16 reference statements)

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“… 6 , 22 , 26 Primary intestinal Hodgkin's lymphoma is rare, reported only in the form of case reports and small series. 27 , 28 However, two patients with primary intestinal Hodgkin's lymphoma involving jejunum and descending colon were seen in our study ( Fig. 2C ).…”

Section: Discussionmentioning

confidence: 50%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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A bstract Introduction Gastrointestinal (GI) tract is the most common site of extranodal lymphoma accounting for 30–40% of the cases. In Western countries, stomach is the most common site of GI lymphoma, whereas in the Middle East and Mediterranean countries, small intestine is commonly involved. Studies about primary intestinal lymphoma (PIL) are heterogeneous in anatomical distribution, presentation, and histological subtypes. The present study was aimed at studying the anatomical distribution, histological subtypes, and clinical characteristics at tertiary care centers. Materials and methods The present study was retrospective, conducted between 2006 and 2020. Patient's data were collected from institutional medical records. PIL was diagnosed by Lewin's criteria. After histological diagnosis, PIL was classified as per the World Health Organization (WHO) criteria and staging was done according to the Ann Arbor classification as modified by Musshoff. Results A total of 941 lymphoma cases were diagnosed during the study period between 2006 and 2020 consisting of 238 Hodgkin's lymphoma and 703 non-Hodgkin's lymphoma (NHL) cases. PIL constituted 5.8% of all lymphoma cases (55 out of 941) and 50.9% (55 of 108) of all primary GI lymphoma. Median age at diagnosis was 44 years and comprised predominantly males (85.45%). Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma were the most common histological subtype (78%) seen. Two patients with primary Hodgkin's lymphoma involving the intestine were seen. T-cell lymphoma was seen in three (5.4%) patients. Ileocecal region was the most common site involved (27%). The common presenting complaints were intestinal obstruction (40%) requiring surgical resection and abdominal pain (32%). Majority of the patients presented in the early stages (I and II). Conclusion Our study demonstrates the pattern of distribution and various histological subtypes of PIL including the rare variants like primary intestinal Hodgkin's lymphoma. Relatively more number of patients presented with intestinal obstruction requiring surgery in comparison with other studies. How to cite this article Malipatel R, Patil M, Rout P, et al . Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients. Euroasian J Hepato-Gastroenterol 2021;11(2):71–75.

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Section: Discussionmentioning

confidence: 50%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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“…Primary gastrointestinal non-Hodgkin's lymphomas (PGINHL) are one of the rare lymphoproliferative neoplasms arising from lymphatic tissue below the mucosal membrane of the gastrointestinal tract (GIT), accounting for less than 5% of GIT lymphomas [ 2 ]. The criteria (Dawson et al's) to define primary gastrointestinal (GI) lymphoma are as follows: (a) the GI tract is predominantly affected with lymph node involvement confined to drainage area of the primary site; (b) there is no hepatic or splenic involvement or palpable superficial node; (c) normal chest radiograph; and (d) the peripheral white blood cell count is normal [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Uncommon Presentation of Isolated Jejunal Lymphoma Masquerading as Crohn’s Disease

Sattavan

Aggarwal

Dikshit

2016

Case Reports in Surgery

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Primary gastrointestinal lymphoma is a rare entity, commonly involving stomach, small bowel, and colorectum. The usual location for small bowel B cell lymphoma is distal ileum due to abundant lymphoid tissue. We are reporting the case of a 53-year-old lady presumptively diagnosed as Crohn's disease on clinical and radiological grounds but histopathologically proven to be an unusual variant of isolated primary non-Hodgkin's lymphoma.

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“…Among the extra-nodal sites, the GIT is the most commonly involved. Primary GI cHL represents less than 5% of GI lymphomas [21,[69][70][71][72][73][74]. The majority of GI cHL are secondary involvement of the GIT in the context of a systemic disease.…”

Section: Chl and Gitmentioning

confidence: 99%

“…Primary GI cHL can present either as tumor-forming lesion involving the whole thickness of the GI wall, or as stricture or ulcerated lesion [21,[69][70][71][72][73][74].…”

Section: Chl and Gitmentioning

confidence: 99%

EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 1)

Zanelli

Sanguedolce

Palicelli

et al. 2021

Cancers

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EBV is the most common persistent virus in humans. The interaction of EBV with B lymphocytes, which are considered the virus reservoir, is at the base of the life-long latent infection. Under circumstances of immunosuppression, the balance between virus and host immune system is altered and hence, EBV-associated lymphoid proliferations may originate. These disorders encompass several entities, ranging from self-limited diseases with indolent behavior to aggressive lymphomas. The virus may infect not only B-cells, but even T- and NK-cells. The occurrence of different types of lymphoid disorders depends on both the type of infected cells and the state of host immunity. EBV-driven lymphoproliferative lesions can rarely occur in the gastrointestinal tract and may be missed even by expert pathologists due to both the uncommon site of presentation and the frequent overlapping morphology and immunophenotypic features shared by different entities. The aim of this review is to provide a comprehensive overview of the current knowledge of EBV-associated lymphoproliferative disorders, arising within the gastrointestinal tract. The review is divided in three parts. In this part, the available data on EBV biology, EBV-positive mucocutaneous ulcer, EBV-positive diffuse large B-cell lymphoma, not otherwise specified and classic Hodgkin lymphoma are discussed.

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Primary Intestinal Hodgkin’s Lymphoma: An Uncommon Presentation

Cited by 9 publications

References 8 publications

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Uncommon Presentation of Isolated Jejunal Lymphoma Masquerading as Crohn’s Disease

EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 1)

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