Primary intracardiac leiomyoma arising from cardiomyocyte progenitors at the right ventriculoseptal interface: case report with literature review

Gaur, Kavita; Majumdar, Kaushik; Kisku, Navnita; Gondal, Ranjana; Sakhuja, Puja; Satsangi, Deepak Kumar

doi:10.1016/j.carpath.2017.03.002

Cited by 7 publications

(10 citation statements)

References 11 publications

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“…Patients with primary intracardial leiomyomas (PICLs) are usually asymptomatic. Gaur et al reviewed four previous asymptomatic cases of PICL in the literature, and added a symptomatic case of their own: the cases ranged in age from 7 months to 47 years (Gaur et al 2017). The case described in this report was also asymptomatic and being aged 74 years, it indicates that this is the oldest case with PICL to be reported in the literature and is probably the 6th case of PICL to be documented in the English literature.…”

Section: Discussionmentioning

confidence: 53%

“…Then echocardiography is the first diagnostic test to be done then if the tumour is not detected, computerised tomography (CT) scan and magnetic resonance imaging (MRI) are used in the process of diagnosis. Additionally, for patients with a risk of coronary stenosis, coronary angiography is done to detect the stenosis (Gaur et al 2017;Hoffmeier et al 2014;Meddeb et al 2018). The advances in diagnosis have helped in increasing the number of cases that can be diagnosed clinically and treated successfully.…”

Section: Discussionmentioning

confidence: 99%

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Primary leiomyoma of the left ventricle leading to sudden and unexpected death in a 74-year-old male: a case report

Yahaya

2020

Egypt J Forensic Sci

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Background Primary cardiac tumours arising from smooth muscle cells are said to be very rare in the literature. Primary leiomyoma of the heart particularly in men is extremely rare. To the best of my knowledge, there are only two reported cases of boys with primary leiomyoma of the heart in the English literature. Most of leiomyoma tumours involving the heart reported in the literature are a result of cardiac extensions of intravenous leiomyomatosis through the inferior vena cava. Case presentation A case of left ventricular primary leiomyoma in a 74-year-old male is reported. He had no known previous history of heart disease but he died suddenly and unexpectedly. At autopsy, the heart measured 420 gm and when it was opened, a solid tumour of size 4 × 3 × 2 cm involving the lower left ventricle on the anterior aspect of the heart was found. The tumour was extending to the left ventricular septum and was growing by protruding into the left ventricle chamber which finally was confirmed histopathologically to be a leiomyoma. Conclusion Cardiac benign tumours are rare and can be life threatening because of embolization following their detachment which is manifested clinically by stroke. Additionally, they are clinically asymptomatic; therefore, they cannot be easily detected. In case of clinical suspicion, echocardiography and other imaging diagnostic tests should be used to confirm presence of a tumour.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Primary leiomyoma of the left ventricle leading to sudden and unexpected death in a 74-year-old male: a case report

Yahaya

2020

Egypt J Forensic Sci

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“…Histologically, IVL resembles typical benign uterine leiomyomas at both the gross and microscopic levels, but with atypical aggressive growth and expansion . It has led to controversy regarding their pathogenesis, diagnosis, and treatment …”

Section: Discussionmentioning

confidence: 99%

“…2,6 It has led to controversy regarding their pathogenesis, diagnosis, and treatment. 7,8 In such patients, who are IVL with intracardiac extension, it may be misdiagnosed and treated improperly because these patients usually present only cardiac symptoms. The diagnosis can be confused with intracardiac thrombosis, myxoma, and the terminal stage of malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Combined transthoracic echocardiography and contrast‐enhanced ultrasonography to trace intravenous leiomyomatosis with intracardiac extension

Luo

2019

Echocardiography

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Intravenous leiomyomatosis (IVL) with intracardiac extension is a rare condition, which the benign tumor invades into the right heart through inferior vena cava. We described the findings of ultrasonography in eight patients with this disease. Transthoracic echocardiography (TTE) can reveal the intracardiac lesion burden and associated compromise. Contrast‐enhanced ultrasonography (CEUS) can trace the origin of the lesion and extension. Therefore, combining TTE with CEUS is used to better characterize this complex lesion and plays a crucial role in guidance of surgical decision.

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“…Histologically, diffuse SMA, desmin positivity and tumor composed of spindle-like cells favored the diagnosis of a leiomyoma. 5 Cardiac leiomyoma adhered to cardiac chamber may be a benign metastasizing leiomyoma or primary cardiac lesion. Benign metastasizing leiomyoma is a rare disease that originates from a histologically benign uterine leiomyoma, and is usually found 3 months to 20 years after hysterectomy or myomectomy.…”

Section: Discussionmentioning

confidence: 99%

Tumor‐like tricuspid myxomatus degeneration with a primary cardiac leiomyoma: A rare case report

Yuan

Zheng

2020

J Card Surg

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We present an unusual case of a 47-year-old male with a cardiac mass arising from the tricuspid valve, which was misdiagnosed as a cystic myxoma. The patient received successful resection of the pathological tissue and tricuspid valvuloplasty. The mass turned out to be tricuspid cystic myxomatus degeneration with a primary cardiac leiomyoma finally. There was no recurrence after complete resection and tricuspid valvuloplasty by 1-year follow-up. To our best of our knowledge, only several cases of primary cardiac leiomyoma have been reported, and this is the first case of primary cardiac leiomyoma involving the tricuspid valve in an adult man. The present case suggests that the tricuspid valve should be another rare site of primary cardiac leiomyoma.

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Primary intracardiac leiomyoma arising from cardiomyocyte progenitors at the right ventriculoseptal interface: case report with literature review

Cited by 7 publications

References 11 publications

Primary leiomyoma of the left ventricle leading to sudden and unexpected death in a 74-year-old male: a case report

Primary leiomyoma of the left ventricle leading to sudden and unexpected death in a 74-year-old male: a case report

Combined transthoracic echocardiography and contrast‐enhanced ultrasonography to trace intravenous leiomyomatosis with intracardiac extension

Tumor‐like tricuspid myxomatus degeneration with a primary cardiac leiomyoma: A rare case report

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