Primary Intracerebral Hemorrhage in Izumo City, Japan: Incidence Rates and Outcome in Relation to the Site of Hemorrhage

Inagawa, Tetsuji; Ohbayashi, Naohiko; Takechi, Akihiko; Shibukawa, Masaaki; Yahara, Kaita

doi:10.1227/01.neu.0000093825.04365.f3

Cited by 108 publications

(78 citation statements)

References 66 publications

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“…Hematom hacmi, İSK ile ilişkili mortalitenin en önemli belirleyicilerindendir (5)(6)(7)(8). İSK için önerilmiş bir çok prognostik model olmasına karşın, bu modeller genellikle hesaplamalar yapmak gerektirir ve hasta başı uygulamalar için çok uygun değildir.…”

Section: Discussionunclassified

“…Tıbbi bakımdaki iyileşmelere karşın, İSK, inmenin İstatistiksel Analiz: Kategorik değişkenler n (%) ve devamlı değişkenler ortalama ± standart sapma (SD) veya medyan-çeyrekler arası aralık (ÇAA) olarak belirtilmiştir. Hematom hacmi modeli, İSK skalası modeli ve İSK-DS modelinin hastane ve intraventriküler kanama varlığı ile ilişkilidir (5)(6)(7)(8).…”

Section: Introductionunclassified

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Hematoma volume as a sole predictor of in-hospital mortality following spontaneous intracerebral

Yıldız¹,

Arsava²,

Akpınar³

et al. 2011

Türk Beyin Damar Hast Derg

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AMAÇ:İntraserebral kanama (İSK) sonrası sonlanımın en önemli öngörücüsü hematom hacmidir. İSK sonrası kötü sonlanımı olan hastaları belirlemek için bir çok öngörücü model geliştirilmiştir. Bu modellerin yalnızca hematom hacmine dayalı öngörüden daha üstün olup olmadıkları bilinmemektedir. Bu çalışmada, hematom hacmi ve yaygın olarak kullanılan iki prognostik modelin, İSK skalası ve İSK derecelendirme skalasının (İSK-DS) İSK tanılı hastalarda hastane içi mortalitenin belirlenmesindeki öngörücülüğünü değerlendirdik. YÖNTEM: Semptom başlangıcından sonraki 24 saat içerisinde bilgisayarlı beyin tomografisi çekilen İSK tanılı ardışık hastalar çalışmaya dahil edilmiştir. Hematom hacmi ABC/2 yöntemi ile hesaplanmıştır. Her bir hastanın İSK skalası ve İSK-DS puanları belirlenmiştir. Sonlanım ölçütü olarak hastane içi mortalite esas alınmıştır. Hematom hacmi modeli, İSK skalası modeli ve İSK-DS modelinin öngörücülüğü ROC eğrisi altında kalan alanların hesaplanması ile değerlendirilmiştir. HEMATOMA VOLUME AS A SOLE PREDICTOR OF IN-HOSPITAL MORTALITY FOLLOWING SPONTANEOUS INTRACEREBRALABSTRACT BACKROUND: Hematoma volume is the most important predictor of outcome following intracerebral hemorrhage (ICH). A number of predictive models have been developed to identify patients with unfavorable prognosis after ICH. It is not known whether they are superior to predictions based solely on hematoma volume. In this study we assessed the predictive accuracy of hematoma volume and two widely used prognostic models -ICH scale and ICH grading scale (ICH-GS) -in determining in-hospital mortality in patients with ICH. METHODS: A consecutive series of patients with ICH and cranial computed tomography imaging within 24 hours of symptom onset were included into the study. Hematoma volume was calculated by using the ABC/2 method. ICH scale and ICH-GS scores of each patient were determined. The outcome variable was in-hospital mortality. The overall predictive ability of hematoma volume, ICH scale and ICH-GS were assessed by computing the area under the receiver-operating characteristic curves (AUC). RESULTS: Among a total of 193 (116 male, 77 female, mean age 66±13 years) patients included in the study, 75 (39%) died during hospitalization. The AUC was 0.761 (95%CI: 0.694-0.819) for hematoma volume, 0.797 (95%CI: 0.733-0.852) for ICH score and 0.784 (95%CI: 0.719-0.840) for ICH-GS (p>0.05). On the other hand the smallest hematoma volume at which the positive predictive value for mortality was 100% was 130 mL. CONCLUSION: Hematoma volume, by itself, is not inferior to other prognostic models in predicting in-hospital mortality in patients with ICH.

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Section: Discussionunclassified

Section: Introductionunclassified

Hematoma volume as a sole predictor of in-hospital mortality following spontaneous intracerebral

Yıldız¹,

Arsava²,

Akpınar³

et al. 2011

Türk Beyin Damar Hast Derg

View full text Add to dashboard Cite

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“…Gastric and duodenal ulcer rates should be reported separately and ulcer incidence calculated exclusively from first time verified lesions. 1,2 The aetiology of peptic ulcer was fiercely debated. It is believed that peptic ulcers develop due to an imbalance between aggressive factors (Helicobacter pylori, NSAIDs, gastric acid) and protective factors (mucin, bicarbonate, prostaglandins), leading to an interruption in the mucosal integrity.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Management of Perforated Peptic Ulcer: A Hospital Experience

2015

IJSR

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Out of 1200 patients who presented with peptic ulcer disease (PUD) during the study period, 120 patients underwent emergency laparotomy for perforated peptic ulcers. Of these, 10 patients were excluded from the study due to incomplete data and failure to meet the inclusion criteria. Thus, 110 patients were enrolled giving an average of 11 cases annually and represented 10% of cases. Of these, 28 (21.4%) patients were studied retrospectively and the remaining 82 (78.6%) patients were studied prospectively.

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“…3 Limited sample size has precluded analysis of some predictors of ICH outcome, such as location of hemorrhage and anticoagulant use in most of these studies. 3,4 Furthermore, whereas short-term mortality following ICH is known to be high, the pattern of long-term mortality following ICH and recent trends in ICH mortality have not been well documented. 3 We present a population-based study of ICH outcome, including long-term mortality data, stratification by location of hemorrhage, and a comparison of two large ICH cohorts assembled more than a decade apart.…”

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confidence: 99%

“…22,23 Other studies have shown that lobar hemorrhages have greater average volume than deep cerebral hemorrhages but are less likely to extend into the ventricular system, two counterbalancing influences on prognosis. 4,24 The largest previous population-based study of ICH outcome was performed in Izumo City, Japan. 4 The authors reported on 350 patients ascertained from 1991 to 1998, excluding patients with vascular malformations or coagulopathy.…”

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confidence: 99%

Asymptomatic sinovenous thrombosis in a healthy neonate

Golomb

Edwards-Brown²,

Garg³

2006

Neurology

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Abstract-Objective:To characterize long-term mortality following intracerebral hemorrhage (ICH) in two large population-based cohorts assembled more than a decade apart. Methods: All patients age Ն18 hospitalized with nontraumatic ICH in the Greater Cincinnati/Northern Kentucky area were identified during 1988 (Cohort 1) and from May 1998 to July 2001 and August 2002 to April 2003. Mortality was tabulated using actuarial methods and compared with a log-rank test. Results: There were 183 patients with ICH in Cohort 1 and 1,041 patients in Cohort 2. Patients in Cohort 1 were more likely to be white (p ϭ 0.024) and undergo operation for their ICH (p ϭ 0.002), whereas patients in Cohort 2 were more commonly on anticoagulants (p Ͻ 0.001). Among patients in Cohort 1, mortality at 7 days, 1 year, and 10 years was 31, 59, and 82%. Among patients in Cohort 2, mortality at 7 days and 1 year was 34 and 53%. Mortality rates did not differ between cohorts by log-rank test (p ϭ 0.259). Conclusions: Intracerebral hemorrhage (ICH) mortality did not improve significantly between study periods. Operation for ICH became less frequent, whereas anticoagulant-associated ICH became more common. NEUROLOGY 2006;66:1182-1186 Recent investigations into the surgical and medical management of intracerebral hemorrhage (ICH) prove that large-scale clinical trials for this condition are feasible and provide hope that new treatments may improve patient outcomes.1,2 Outside of clinical trials, changes in medical practice and the natural history of disease are ideally documented in population-based studies that capture all disease cases within a defined community. To date, most population-based studies of ICH outcome have been small and racially homogeneous.3 Limited sample size has precluded analysis of some predictors of ICH outcome, such as location of hemorrhage and anticoagulant use in most of these studies.3,4 Furthermore, whereas short-term mortality following ICH is known to be high, the pattern of long-term mortality following ICH and recent trends in ICH mortality have not been well documented. 3 We present a population-based study of ICH outcome, including long-term mortality data, stratification by location of hemorrhage, and a comparison of two large ICH cohorts assembled more than a decade apart.Methods. Two ICH cohorts from the five-county Greater Cincinnati/Northern Kentucky area (GCNK) were tracked for this study. Cohort 1 was assembled from January 1988 through December 1988 and has been the subject of previous reports. Factors for Hemorrhagic Stroke (GERFHS) study, an ongoing population-based study of ICH and subarachnoid hemorrhage in the GCNK region. 7 The methodology of the GERFHS study has been previously described. 7,8The current study includes all hospitalized cases of ICH that occurred in persons age Ն18 within the five GCNK metropolitan counties during the prescribed periods. For both cohorts, cases were identified by retrospective review of primary and secondary International Classification of Diseases-9 (ICD-9) codes...

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Primary Intracerebral Hemorrhage in Izumo City, Japan: Incidence Rates and Outcome in Relation to the Site of Hemorrhage

Abstract: Marked differences were observed in the incidence rates and outcome of primary ICH in relation to the site of hemorrhage. The differences in outcome were primarily a result of differences in the severity of bleeding for each ICH subtype.

Cited by 108 publications

References 66 publications

Hematoma volume as a sole predictor of in-hospital mortality following spontaneous intracerebral

Hematoma volume as a sole predictor of in-hospital mortality following spontaneous intracerebral

Epidemiology and Management of Perforated Peptic Ulcer: A Hospital Experience

Asymptomatic sinovenous thrombosis in a healthy neonate

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