Primary Intracranial Mucosa-Associated Lymphoid Tissue Lymphoma

Abstract

SUMMARY -Low-grade B cell non-Hodgkin lymphomas typically arise from the marginal zone of the secondary lymphatic follicles. Their intracranial expression is very rare, most frequently affecting the dura mater and the choroid plexus glomi in the lateral ventricles. Their initial evaluation requires the exclusion of more common extra-axial lesions, such as meningiomas, dural metastasis, granulomatous lesions or secondary lymphoproliferative dural extension from body lymphomas. Whenever a ventricular lesion is present, the patient's age and lesion location help narrow the differential diagnosis. Dural-based lymphomas and ventricular/choroid plexus lymphomas are slowgrowing lesions with imaging features similar to meningiomas, which is typically their main dif

Primary central nervous system marginal zone B‐cell lymphoma arising from the dural meninges: A case report and review of literature

“…Mucosa‐associated lymphoid tissue lymphomas are a rare type of low‐grade B‐cell neoplasms that occur in a variety of extranodal sites. They are seen mainly in individuals between ages 40 and 50, and are four to five times more predominant in women as compared to men . These tumors commonly present with nonspecific symptoms including headaches, meningeal irritation, seizures, scalp swelling, and signs of cranial nerve involvement…”

“…When MALT lymphomas involve the CNS, they are most commonly located within the dura mater. They are frequently described on diagnostic imaging as being either dural‐based or leptomeningeal, without any evidence of brain parenchymal infiltration or systemic dissemination . These malignancies can appear on imaging as either single or multiple extra‐axial lesions that are diffusely enhancing, with 95% of studies reporting a dural tail …”

“…Clinical information such as the patient's age, personal medical history, and identification of risk factors for lymphoma is increasingly important. Other diagnostic considerations include metastases, and inflammatory or infectious granulomatous disease such as Wegener's disease, Rosai‐Dorfman disease, syphilis, tuberculosis, or other secondary lymphoproliferative lesions . For example, dural MALT lymphomas have been associated with chronic inflammatory states such as hepatitis C and autoimmune diseases …”

“…They are seen mainly in individuals between ages 40 and 50, and are four to five times more predominant in women as compared to men. 19,20 These tumors commonly present with nonspecific symptoms including headaches, meningeal irritation, seizures, scalp swelling, and signs of cranial nerve involvement. 8 They can sometimes occur in nonlymphatic organs that contain small lymphoid tissue clusters in mucosal and nonmucosal layers, such as the dura mater, skin, or orbital tissues.…”

“…8 They can sometimes occur in nonlymphatic organs that contain small lymphoid tissue clusters in mucosal and nonmucosal layers, such as the dura mater, skin, or orbital tissues. 19 MALT lymphoma has also been described to involve the lung, bladder, salivary glands, conjunctiva, and lacrimal glands. 20 The CNS is nearly absent of mucosa-associated lymphoid tissue.…”