Primary intradural extraarachnoid Hodgkin lymphoma of the cervical spine

Abstract

<jats:p>✓ This 42-year-old man presented with an intradural extramedullary mass in his lower cervical spine. On imaging studies the lesion mimicked the appearance of a meningioma. At surgery, the mass was found to be an intradural extra-arachnoid tumor. An intraoperative pathological examination determined the lesion to be a Hodgkin lymphoma. The procedure was limited to biopsy sampling and the patient was treated further with adriamycin, bleomycin, vincristine, and dacarbazine chemotherapy, after which remission was demonstrated both clinically and on images. Analysis of a frozen section obtained during the procedure aided in the diagnosis of the tumor, thus preventing further resection and the potential neurological complications associated with more radical resection. To the authors’ knowledge this is the first reported case of a presumed primary intradural extraarachnoid Hodgkin lymphoma.</jats:p>

Primary Intradural Hodgkin’s Lymphoma in Lumbosacral Spine

“…Higgins & Peschel reported variable incidence of 1.15-7.6% for the spinal cord compression caused by epidural HL [5]. on literature research, we could find only six reports on primary HL of the spinal canal [5][6][7][8][9][10], out of which only one was intradural in the cervical region [10], leaving behind the rest in the extradural space. This is the second case report of primary intradural HL and the first case to involve the lower lumbar and sacral spine by this entity.…”

Primary spinal intradural extramedullary lymphoma causing cauda equina syndrome

“…Intra-operative evidence of the dural attachment might be due to its origin from these lymphatic spaces. [2] Histopathology of the tumor was confirmatory of non-Hodgkin's lymphoma. The diagnosis was also confirmed by immunohistochemistry showing CD20 positivity.…”

“…in 2006. [2] They operated on a cervical intradural extramedullary lesion which they thought initially as meningioma. After performing a laminectomy, the biopsy of the lesion was in favor of Hodgkins lymphoma; hence, the surgery was abandoned and the patient subsequently received chemotherapy.…”

Solitary intradural extramedullary lymphoma of the cervical spine

“…To the best of our knowledge, only 2 reports have documented an intradural extramedullary lesion. 1,7 However, in 1 of these 2 cases, whether the tumor was solitary or part of systemic lesions was not clarified. 1 Although Heran et al 7 reported the first case of primary intradural extraarachnoid Hodgkin lymphoma of the cervical spine, mediastinal and paratracheal lymphadenopathies were seen in that case.…”

“…1,7 However, in 1 of these 2 cases, whether the tumor was solitary or part of systemic lesions was not clarified. 1 Although Heran et al 7 reported the first case of primary intradural extraarachnoid Hodgkin lymphoma of the cervical spine, mediastinal and paratracheal lymphadenopathies were seen in that case. Thus, the present case is the first instance of presumed solitary intradural extramedullary lymphoma of the cervical spine.…”