Primary intramedullary spinal cord lymphoma: a population-based study

Yang, Wuyang; Garzón-Muvdi, Tomás; Braileanu, Maria; Porras, Jose L.; Caplan, Justin M.; Rong, Xiaoming; Huang, Judy; Jallo, George I.

doi:10.1093/neuonc/now178

Cited by 17 publications

(20 citation statements)

References 44 publications

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“…13 Also, family support may increase compliance or adherence to cancer-related therapy. [14][15][16][17] In the present study, we observed the negative effect of separated/divorced/widowed status on the outcome of patients with SmCC of the salivary gland in univariate Cox survival analysis, but without statistical significance after adjusting for other confounding factors. The association of marital status and survival is required to be explored in a large cohort of patients in the future.…”

Section: Discussionmentioning

confidence: 56%

<p>Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study</p>

Bai

Zhao

Pan

2019

CMAR

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Background: Small cell carcinoma (SmCC) of the salivary gland is rare, and the characteristics and survival are not well defined due to only case reports or case series being reported. The present study aimed to describe the clinicopathological characteristics and determine the factors associated with survival of this rare cancer. Materials and methods: A population-based study was carried out to investigate clinical characteristics and prognosis of SmCC of the salivary gland using prospectively extracted data from the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2016. Results: Totally, 198 patients with SmCC of the salivary gland were identified with an average age of 72.6±12.4 and a male to female ratio of 3.4:1. The lesions of most patients (167/198) were located in the parotid gland. The median overall survival (mOS) of all patients is 25.0 months. The 1-, 3-, 5-and 10-year survival rate was 65.7%, 40.9%, 33.0% and 22.7%, respectively. Surgery could prolong significantly the mOS by almost 17.0 months (28.0 months vs 11.0 months; P<0.01). Radiotherapy, as well as radiotherapy after surgery, could prolong the mOS (P<0.01 for both). Patients who received chemotherapy had significantly longer overall survival time than those without chemotherapy (28.0 months vs 20 months; P=0.04). The survival analysis demonstrated that old age (>72 years), lymph node (N3) and distant metastases were independent factors for poor survival, whereas radiotherapy was an independent factor for favorable survival. Conclusion: Small cell carcinoma of the salivary gland is a rare disease, and old age, lymph node and distant metastases, and radiotherapy were significantly associated with prognosis. In order to understand this disease more thoroughly, more cases with adequate information are required.

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Section: Discussionmentioning

confidence: 56%

<p>Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study</p>

Bai

Zhao

Pan

2019

CMAR

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“…Intramedullary lymphoma with spinal cord involvement is rare, accounting for 1% of PCNSL (5). The average age of the disease was 50 years, with a higher prevalence being observed in men and 50-60 years being the peak period of incidence (6). The clinical symptoms of primary intramedullary spinal cord lymphoma are usually non-speci c and related to the levels of the spinal cord involvement (7).…”

Section: Discussionmentioning

confidence: 99%

An overlooked cause of longitudinally extensive spinal cord lesions: Primary central nervous system lymphoma

Wang¹,

Qi²,

Han³

et al. 2020

Preprint

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Background: Primary central nervous system lymphoma (PCNSL ) is a rare and aggressive malignant tumor. It is easy to be misdiagnosed due to its low incidence and unspecific presentations in clinical practice. PCNSL mainly occurs intracranially in the brain while spinal cord is rarely involved. Case presentation: Here we report a 76-year-old woman who had a suspicious tumor history and presented retardant paralysis, bladder dysfunction and sensory loss of the lower limbs. Magnetic resonance imaging (MRI) of the thoracic spine disclosed longitudinally extensive lesions extending from thoracic 4 (T4) to lumbar 1 (L1) vertebral level with an enhanced nodular lesion noting at levels of T10 and T11 . In order to further identify the cause, the whole body 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed tomography (CT) was performed and showed a hypermetabolic nodule corresponded to MRI enhancing lesions, which further suggesting the possibility of a tumor. The patient then underwent a surgical resection and spinal cord biopsy confirmed the diagnosis of non-Hodgkin's lymphoma (diffuse large B-cell type). The patient then received a high-dose chemotherapy based on methotrexate combined with Rituximab. Unfortunately, the symptoms of this patient have not been improved significantly after three rounds of chemotherapy. Conclusion: Our case indicates that PCNSL may also serve as a possible cause for longitudinally extensive spinal cord lesions, especially the patients who had a suspicious tumor history, MRI enhancing lesion s in the spinal cord corresponded to hypermetabolic nodules on 18 F-FDG- PET/CT at the same level.

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“…Yang et al conducted a population-based study of 346 PISCL patients using the Surveillance, Epidemiology, and End Results (SEER) database. They found that the clinicopathologic factors age, marital status, race, tumor stage, tumor histology, and year of diagnosis were correlated with PISCL patient survival outcome [30]. However, there has been no study developing a clinical nomogram for PISCL patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Nomograms Predict Survival Outcome of Primary Intramedullary Spinal Cord Lymphoma Patients

Yang

2019

Med Sci Monit

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BackgroundPrimary intramedullary spinal cord lymphoma (PISCL) is a rare cause of myelopathies. Considering its poor prognosis, it is essential to determine the appropriate treatment strategies and to develop nomograms to predict survival outcome for PISCL patients.Material/MethodsData were collected from the Surveillance, Epidemiology and End Results (SEER) database. We used 364 patients to investigate overall survival (OS) and 289 patients for cancer-specific survival (CSS). Kaplan-Meier method was to evaluate correlations of survival with different treatment strategies and clinicopathologic factors. Univariate and multivariable analyses were conducted to assess OS and CSS based on different variables. Risk factors were integrated to build nomograms.ResultsMost of the 414 PISCL patients diagnosed with positive histology had diffuse B cell lymphoma, were under 60 years old, were male, were of white race, had 1 primary tumor, were married, were low stage, and had previously undergone chemotherapy. We found that radiation therapy had no effect on patient OS and CSS, and patients receiving chemotherapy alone tended to have better OS and CSS in comparison with other groups. In addition, we showed that clinicopathologic factors, including histologic type, age, stage, and marital status, could serve as independent prognostic factors for PISCL patient OS and CSS. These factors were utilized to construct nomograms. The calibration curves demonstrated good agreement. The concordance indexes for OS and CSS were 0.672 (P=0.024) and 0.683 (P=0.029), respectively.ConclusionsPractical nomograms were established for patients’ OS and CSS. Besides, this study can guild clinician to make the right decision for appropriate treatment of PISCL patients.

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Primary intramedullary spinal cord lymphoma: a population-based study

Cited by 17 publications

References 44 publications

<p>Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study</p>

<p>Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study</p>

An overlooked cause of longitudinally extensive spinal cord lesions: Primary central nervous system lymphoma

Nomograms Predict Survival Outcome of Primary Intramedullary Spinal Cord Lymphoma Patients

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