Primary intraocular ancient schwannoma: A case report and review of the literature

Mortuza, S.; Esmaeli, Bita; Bell, Diana

doi:10.1002/hed.23329

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…They alone constitute 25-40% of head and neck tumors [2]. Several cases of extracranial ancient schwannoma have been reported in English literature [2][3][4][5]. However an ancient variant involving CPA is particularly rare and our case presentation is one of them.…”

Section: Introductionmentioning

confidence: 70%

An Unusual Variant of Cerebellopontine Angle Schwannoma in a Young Nepalese Girl

Kt¹,

Koirala²

2017

J Clin Exp Pathol

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An unusual variant of cerebellopontine angle schwannomas is extremely rare. Histologically, the tumor has atypical changes misleading the diagnosis. We report 20-year-old Nepalese girl from far-eastern community presented with features of raised intracranial pressure and difficulty in walking. MR imaging revealed intensely contrast enhanced well defined huge solid tumor in right cerebellopontine angle region with foci of multiple cystic components. The tumor was displacing the brain stem structures with dilatation of lateral and third ventricles. The altered radiological finding made discrepancy diagnosis. Conventional angiography demonstrated major feeders from the auricular branch of the right external carotid artery. The tumor was embolized with polyvinyl alcohol particles followed by gross total lateral suboccipital excision. Histopathology unit detailed it as ancient schwannoma with pleomorphic changes.

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Section: Introductionmentioning

confidence: 70%

An Unusual Variant of Cerebellopontine Angle Schwannoma in a Young Nepalese Girl

Kt¹,

Koirala²

2017

J Clin Exp Pathol

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“…1 This tumor is thought to arise from the Schwann cells of the short or long ciliary nerves that traverse through the uveal tract. 1 A literature review on intraocular schwannoma, by You and colleagues, 1,5,6 found 46 cases as of 2013, and further review of the English literature and English-translated literature revealed only two additional welldocumented cases.…”

Section: Discussionmentioning

confidence: 99%

Intraocular schwannoma with extrascleral extension

Udyaver

Lim

Milman

et al. 2020

European Journal of Ophthalmology

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Purpose To report a rare case of intraocular schwannoma with extrascleral extension in a patient with juvenile idiopathic arthritis and to review the literature for this topic. Methods Case report. Results A 19-year-old male with a history of juvenile idiopathic arthritis was referred for diagnosis and management of an episcleral mass, initially thought to be focal nodular scleritis. The ocular surface of the right eye revealed an elevated amelanotic episcleral nodule inferonasally, with thin strands of overlying sclera, feeding episcleral vessels, and measuring 11 mm × 11 mm in diameter and 5 mm in thickness. Ophthalmoscopic examination revealed a minimally pigmented ciliochoroidal tumor measuring 13 mm in diameter and 11.4 mm in total thickness and without associated subretinal fluid, orange pigment, or drusen. Ultrasound biomicroscopy and anterior-segment optical coherence tomography confirmed a solid mass with scleral disruption and extraocular extension. Shave biopsy revealed palisading spindle cells and interspersed eosinophilic fibrillary cytoplasmic processes, forming Verocay bodies. The specimen stained positive for S-100 and negative for Melan-A, consistent with benign schwannoma. Observation was recommended. Conclusion Intraocular schwannoma is a rare, benign uveal tumor that can demonstrate extrascleral extension, mimicking inflammatory and malignant neoplastic processes. Clinical diagnosis is challenging, and tissue biopsy is required for definite diagnosis.

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“…Intraocular schwannoma is an extremely rare benign neoplasm that arises from Schwann cells. To date, there has been no report of malignant intraocular schwannoma (5,16,18). A confirmed diagnosis depends on the immunohistochemical analysis of biopsy results, which can distinguish schwannoma from other spindle-cell tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Uveal schwannoma is also termed a 'pseudomelanoma', as it simulates the most common type of primary intraocular tumor, uveal melanoma; this term reflects the difficulty in clinically distinguishing the schwannoma from uveal malignant melanoma (11)(12)(13). In certain previously reported cases, eyeball enucleation was performed due to a diagnosis of malignant melanoma, and only after subsequent histopathological examination of the surgical specimen was a benign tumor revealed (14)(15)(16)(17)(18). In the present study, the cases of 3 patients with intraocular schwannoma who underwent surgical excision locally, retained the eyeball or even achieved an improvement in visual acuity are reviewed.…”

Section: Introductionmentioning

confidence: 99%

Intraocular schwannoma: A case series of 3�patients

Cheng

Wang

et al. 2018

Oncol Lett

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Schwannoma is a proliferation of neoplastic Schwann cells. Schwannomas comprise 8-10% of all primary intracranial tumors. Primary intraorbital schwannoma arising from the ciliary nerves in the uvea, which accounts for 1-2% of all intracranial tumors, is a rare intraocular neoplasm. Intraocular schwannoma frequently masquerades as melanoma, reflecting the difficulty in clinically distinguishing it from malignant melanoma and the requirement for a histopathological diagnosis. The aim of the present study was to report a case series of 3 patients diagnosed with intraocular schwannoma at the Department of Ophthalmology, Peking University People's Hospital (Beijing, China). Patients with intraocular schwannoma were identified by searching the computerized database and patient medical records of the Department of Ophthalmology of Peking University People's Hospital. The patients (2 men and 1 woman; mean age, 34 years; age range, 25-48 years) were all treated by trans-scleral local resection, and schwannoma was confirmed by biopsy. The study found that choroidal schwannoma has a variety of clinical manifestations, with iridodialysis, subluxation of the lens and exudative detachment of the retina observed. The present study indicates that a pathological biopsy is required for diagnosis and that the optimal therapy is local resection.

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Primary intraocular ancient schwannoma: A case report and review of the literature

Abstract: We describe herein a case of intrascleral schwannoma with ancient changes arising within the globe of the right eye occupying the subretinal space and completely replacing the vitreous body.

Cited by 12 publications

References 24 publications

An Unusual Variant of Cerebellopontine Angle Schwannoma in a Young Nepalese Girl

An Unusual Variant of Cerebellopontine Angle Schwannoma in a Young Nepalese Girl

Intraocular schwannoma with extrascleral extension

Intraocular schwannoma: A case series of 3�patients

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