Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report

Shamim, Thorakkal; Varghese, Vengal Ipe; Shameena, PM; Sudha, S

doi:10.2334/josnusd.50.95

Cited by 16 publications

(12 citation statements)

References 7 publications

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“…[210] In the present case, owing to the massive size and a history of 4 years, a thorough metastatic work-up was carried out, which revealed neither regional lymph node nor distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Intraosseous adenoid cystic carcinoma of maxilla: A rare case report

et al. 2013

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Adenoid cystic carcinoma (ACC) accounts for approximately 6-10% of all salivary gland tumors. Palatal minor salivary glands, parotid, and sub-mandibular glands are usually affected. Rarely, these lesions arising intraosseously have been reported. Mandible is commonly involved than maxilla. The present case is a giant ACC involving the right maxilla. A thorough clinical and radiographic evaluation was performed to assess the involvement of surrounding vital structures along with a meticulous metastatic work-up. Computed tomography showed a giant lesion in maxilla encroaching the left nasal fossa, antrum, buccal space, and oral cavity. No metastasis was noted. Histological evaluation from multiple sites showed both cribriform and solid patterns. Radiotherapy was given as patient did not comply for surgery. Though central ACC is extremely rare, especially in maxilla, it should be included in the differentials for lesions in maxilla. A prompt diagnosis with treatment and long-term follow-up is advised in such cases.

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Section: Discussionmentioning

confidence: 99%

Intraosseous adenoid cystic carcinoma of maxilla: A rare case report

et al. 2013

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“…Very rarely, ACCs may arise intra-osseously, commonly in the posterior mandible of an adult [5]. Bone invasion or a perineural spread can sometimes cause pain or hypoesthaesia.…”

Section: Discussionmentioning

confidence: 99%

“…Expressions of S100 and glial fibrillary acidic protein (GFAP) in ACCs may possibly indicate that Schwann cell differentiation in modified myoepithelial cells correlates with perineural invasion in this salivary gland malignancy. ACCs also show positivity to beta-catenin, E-cadherin, C-kit, high expressions of p53 and bcl-2, and low Ki-67 [5,10].…”

Section: Immunohistochemically Accs Can Be Divided Into Two Groupsmentioning

confidence: 99%

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Adenoid Cystic Carcinoma of the Buccal Mucosa: A Case Report with Review of Literature

Santhanam¹,

Aravindhan

2014

JCDR

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A 48-year-old female patient presented with complaint of a swelling in the left cheek, in relation to left upper back tooth region. The swelling was present since 1 year and it had arisen as a small one, after extraction of a decayed left upper back tooth. History revealed that the swelling had increased gradually to attain its present size and that it was not associated with pain. There was no relevant medical, surgical or personal history. On extra oral examination, there was no evidence of erythema, ulceration or ecchymosis. Single left submandibular lymph node that was mobile, firm, non-tender and of size 0.5x0.5 cm, was palpable. Intra oral examination revealed a single localized dome shaped swelling of size 2x3 cm in the left buccal mucosa, in relation to 27 region, which extended posteriorly till the faucial pillars of the tonsils [Table/ Fig-1]. The mucosa which overlay the swelling was erythematous in nature and its surface was smooth. There was no surface discharge, the swelling was firm in consistency and it was nontender. The swelling was fixed to the underlying tissue and the area which surrounded the swelling, appeared to be normal. Clinical differential diagnosis included benign mesenchymal neoplasms, reactive or inflammatory conditions of minor salivary glands, benign or low grade malignant tumours of salivary gland origin, and metastatic tumour deposits of distant site. An orthopantomograph was taken and it revealed no bony changes in the maxilla or the mandible. Lesion was excised in toto, it was Dentistry Section aBstRaCt Minor salivary gland neoplasms of the buccal mucosa are relatively uncommon. Adenoid cystic carcinoma (ACC), a well-defined entity, occurs most of the times in the parotid, submandibular glands and palate, as far as the intraoral site is concerned. Adenoid cystic carcinoma tends to have an indolent, extended clinical course with wide local infiltration and late distant metastases. We are presenting a case of an adenoid cystic carcinoma of the buccal mucosa in a 48-year-old female patient.[table/ Fig-1]: Clinical picture depicting a mass of the buccal mucosa

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“…[3,4] The characteristic features include slow growth, gradual destruction of surrounding tissues, perineural invasion, and unpredictable distant metastasis, commonly to lungs and bones. [11,14,15] In this case, the tumor presented with pain and swelling in the mandibular 3 rd molar region in a 48-year-old male patient with tingling sensation in the left chin region. These features are similar to those reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

A rare case report of intraosseous adenoid cystic carcinoma of the mandible

Iyengar¹,

Vasudev²,

Karibasappa³

et al. 2016

IJMDCR

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Adenoid cystic carcinoma (ACC) is an uncommon malignant tumor of the salivary glands. It generally involves the minor salivary glands, and the hard palate is the most common site. ACC presents as a slow growing mass with mild pain and usually demonstrates perinueral invasion. An intraosseous occurrence of ACC is a very rare and when it occurs the mandible is more commonly involved than the maxilla. A Pubmed search has revealed only 26 case reports of intraosseous ACC involving the mandible until date. Hence, reporting one such rare case of intraosseous ACC in a 49-year-old male patient involving the mandible.

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Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report

Cited by 16 publications

References 7 publications

Intraosseous adenoid cystic carcinoma of maxilla: A rare case report

Intraosseous adenoid cystic carcinoma of maxilla: A rare case report

Adenoid Cystic Carcinoma of the Buccal Mucosa: A Case Report with Review of Literature

A rare case report of intraosseous adenoid cystic carcinoma of the mandible

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