Primary intraosseous carcinoma arising in dentigerous cyst: Case report

Marchal, Alix; Gérard, Éric; Curien, Rémi; Bourgeois, Geoffrey

doi:10.1016/j.ijscr.2020.10.059

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…As of 2001, the 5-year survival rate of reported cases was 52%. 10 Cases arising in cysts often appear to be better differentiated and have a more prolonged course, but the 5-year survival rate of reported cases is slightly lower, at 40%. When cysts are found to harbour incidental dysplasia or carcinoma in situ after enucleation, conservative close follow-up is appropriate.…”

Section: Discussionmentioning

confidence: 98%

“…Distant metastasis is infrequent and is usually to the lung. As of 2001, the 5‐year survival rate of reported cases was 52% 10 . Cases arising in cysts often appear to be better differentiated and have a more prolonged course, but the 5‐year survival rate of reported cases is slightly lower, at 40%.…”

Section: Discussionmentioning

confidence: 99%

“…PIOC from odontogenic cysts have an incident rate of 0.3%-2% and only 16%-51% of them are PIOC from dentigerous cyst. 10,11 As described in a recent review 10 PIOC shows a male predilection (69.3%) and is more frequent in the posterior body and ramus of the mandible than in the maxilla (7:1), Maxillary lesions are usually in the anterior segment. Determining origin is important for diagnosis.…”

Section: Introductionmentioning

confidence: 91%

“…PIOC arising in a dentigerous cyst is a rare observation. PIOC from odontogenic cysts have an incident rate of 0.3%–2% and only 16%–51% of them are PIOC from dentigerous cyst 10,11 …”

Section: Introductionmentioning

confidence: 99%

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A primary intraosseous squamous cell carcinoma case report and literature review. The new WHO classification

et al. 2022

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Aim: Cyst-like lesions in the mandible rarely develop into malignancies, and the reported incidence is between 0.3% and 2%. The present study describes a rare case of primary intraosseous squamous cell carcinoma of the mandible arising from an odontogenic cyst. Materials and Methods:An 80-year-old male was referred to Trieste University Maggiore Hospital (Trieste, Italy), with acute pain in the left retromolar area.An initial examination revealed extra oral swelling without paresthesia of the IAN.Following an intraoral examination, the oral mucosa was edematous, percussion pain was experienced on the lower left second molar. Panoramic radiography revealed a retained lower left wisdom tooth and an irregular radiolucent area between the lower left second molar and the mandibular angle with clear margins. Computed tomography revealed diffuse bone resorption and an extensive loss of cortical bone on the lingual side. Results:A biopsy was performed during the surgery to remove the second lower left molar and the wisdom tooth, the pathological diagnosis was of squamous cell carcinoma arising from the epithelial lining of the odontogenic cyst. MRI with contrast agent was also performed. Shortly after the patient has been proposed a complete resective surgery of the mass including the infiltrated areas and then a reconstructive part to restore the function and aesthetic. Conclusion:The follow-up of a large inflammatory cyst is essential for early diagnosis of malignant neoplasm. This approach allows lower invasive treatments and major survival of these patients.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

“…PIOC arising in a dentigerous cyst is a rare observation. PIOC from odontogenic cysts have an incident rate of 0.3%–2% and only 16%–51% of them are PIOC from dentigerous cyst 10,11 …”

Section: Introductionmentioning

confidence: 99%

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A primary intraosseous squamous cell carcinoma case report and literature review. The new WHO classification

et al. 2022

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“…According to the definition established by the World Health Organization, a dentigerous cyst (DC), formerly known as a follicular cyst, is a pathology embracing the crown of an unerupted tooth that attaches to its cementoenamel junction [ 1 , 2 ]. Such cysts sometimes transform into neoplastic compositions, which has been presented in several case reports [ 3 , 4 ]. DCs are the second most common bone cyst and affect 0.91–7.3% of the population [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Factors influencing an eruption of teeth associated with a dentigerous cyst: a systematic review and meta-analysis

et al. 2021

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Background A dentigerous cyst (DC) is a pathology embracing the crown of an unerupted tooth at risk of malignant transformation. The causal tooth is usually removed together with the cyst. However, if there are orthodontic contraindications for extraction, two questions arise. (1) Which factors favor spontaneous eruption? (2) Which factors imply the necessity of applying orthodontic traction? This systematic review aimed to identify factors conducive/inconducive to the spontaneous eruption of teeth after dentigerous cyst marsupialization. Methods In accordance with the PRISMA guidelines, the main research question was defined in the PICO format (P: patients with dentigerous cysts; I: spontaneous tooth eruption after surgical DC treatment; C: lack of a spontaneous tooth eruption after surgical DC treatment; O: determining factors potentially influencing spontaneous tooth eruption). The MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched for keywords combining dentigerous/odontogenic/follicular cysts with teeth and/or orthodontics, as well as human teeth and eruption patterns/intervals/periods/durations. The following data were extracted from the qualified articles (4 out of 3005 found initially): the rate of tooth eruption after surgical treatment of the cyst, the age and sex of the patients, the perpendicular projection distance between the top of the tooth cusp and the edge of the alveolar process, tooth angulation, the root formation stage, the cyst area, and the eruption space. The articles were subjected to risk of bias and quality analyses with the ROBINS-I protocol and the modified Newcastle–Ottawa QAS, respectively. Meta-analyses were performed with both fixed and random effects models. The GRADE approach was used to evaluate the quality of the evidence. The systematic review was registered in PROSPERO under ID CRD42020189044. Results Nearly 62% of DC-associated premolars erupted spontaneously after cyst marsupialization/decompression. Young age (mean = 10 years) and root formation not exceeding 1/2 of its fully developed length were the factors likely to favor spontaneous eruption. Conclusion The small number of published studies, as well as their heterogeneity and the critical risk of bias, did not allow the creation of evidence-based protocols for managing teeth with DC after marsupialization. More high-quality research is needed to draw more reliable conclusions.

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Imaging findings in a case of primary intraosseous carcinoma arising from a mandibular cyst

Kami,

Chikui,

Fujii

et al. 2024

Oral Radiol

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Primary intraosseous carcinoma arising in dentigerous cyst: Case report

Cited by 7 publications

References 10 publications

A primary intraosseous squamous cell carcinoma case report and literature review. The new WHO classification

A primary intraosseous squamous cell carcinoma case report and literature review. The new WHO classification

Factors influencing an eruption of teeth associated with a dentigerous cyst: a systematic review and meta-analysis

Imaging findings in a case of primary intraosseous carcinoma arising from a mandibular cyst

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