Primary intraosseous carcinoma of the mandible: A report of two cases

Abstract

Primary intraosseous carcinoma arising as a de novo lesion is a unique and rare carcinoma affecting the jaws, especially at younger ages. Two case reports, a 26-year-old Indian female with primary intraosseous squamous cell carcinoma and a 16-year-old Indian male with intraosseous carcinoma arising in an odontogenic cyst, both within the body of the mandible, are presented here.

Primary De Novo Intra-Osseous Carcinoma of Mandible: A Rare Case Report

“…Primary intraosseous carcinoma (PIOC) was first described by Loos in 1913 as a central epidermoid carcinoma of the jaw [5,6]. Willis in 1948 renamed it as an intra-alveolar epidermoid carcinoma [7].…”

“…According to World Health Organisation (WHO) primary intraosseous carcinoma is defined as "A Squamous cell carcinoma arising with in the jaw , having no initial connection with the oral mucosa and presumably developing from residues of the odontogenic epithelium" [7]. There are several classifications present, but the widely accepted is Waldron and Mustoe's classification according to the PIOC origins [3][4][5][6]8]. PIOC affects patients ranging from 4-90 yrs of age with mean age of 52 years [9,10].…”

“…PIOC affects patients ranging from 4-90 yrs of age with mean age of 52 years [9,10]. It is more frequently located in the mandible than maxilla [3][4][5][6]9,10], mostly involving the posterior region of the jaw [10]. It affects men more than women with the ratio about 2.2:1.…”

“…There must be histological evidence of squamous cell carcinoma and c. Chest radiographs must be clear at the time of diagnosis and throughout a follow-up period of at least 6 months to rule out a distant primary tumor [11]. Lucas presumed that carcinoma may arise from the odontogenic rests or from the epithelium entrapped in the deeper structures during fusion of facial process [5,12]. For a carcinoma to develop the presence of epithelium is mandatory and it can include remnants of dental lamina, remnants of Hertwig's epithelial root sheath, remnants of enamel organ, odontogenic tumors or odontogenic cyst lining, entrapped epithelium during fusion of facial process and salivary gland inclusions [5].…”

Dentigerous Cyst Transforming Into Mucoepidermoid Carcinoma of the Maxillary Sinus in a 10 Year Old Child – A Rare Case Report.

“…According to Browne et.al 1 the sex predilection of dentigerous cyst is 1.6:1(male: female). Sometimes, lining of dentigerous cysts may transform into malignancies like squamous cell carcinoma(SCC) 2,3,4,5,6 (50%), mucoepidermoid carcinoma(MEC) 7,8 (50%), ameloblastoma 9 (14.6%) and adenomatoid odontogenic tumour(AOT) 10 (73%).…”