Primary Intraosseous Verrucous Carcinoma Developing from a Maxillary Odontogenic Cyst: Case Report

Abstract

Primary intraosseous carcinoma (PIOC) is an extremely rare lesion, almost always occurring in cranial bones. The origin of this tumor, specific to the maxillae, is associated with the cells of the epithelial rests of Malassez. Among the histotypes which can be included in these neoplasms, verrucous carcinoma is of particular interest due to its rarity: only a single case has been reported to date. After a short survey of the literature, the authors describe a directly observed case of verrucous carcinoma arising from a maxillary odontogenic cyst.

Prevalence of cysts and tumors around the retained and unerupted third molars in the Indian population

“…32 Verrucous carcinoma developing in an odontogenic cyst has also been reported. 33 The incidence, multiple presentation and recurrence of aggressive cysts of the jaws and the malignant transformation of cysts has been discussed by Stoelinga and Bronkhorst. 34 According to their study it seems justified to estimate the incidence of malignant change, including squamous cell carcinoma and mucoepidermoid tumor, as varying from 1 to 2%.…”

Intraosseous verrucous carcinoma arising from an orthokeratinized odontogenic keratocyst: A report of a rarest entity

“…The origin of this tumor, specific to the maxillae, is associated with the cells of the epithelial rests of Malassez. [9] Cases of odontogenic cysts with either verrucous changes or VC in the lining published so far in literature have been shown in Table 1.…”

Verrucous carcinoma arising from a previous cystic lesion: a case report

“…Roughly 85% of PIOSCC is well-to-moderately differentiated SCC, and only 3% is VC. VC arising from OC is a type of PIOSCC and is referred to as primary intraosseous verrucous carcinoma (PIOVC) [ 8 ].…”