Primary intravascular myxoid leiomyosarcoma of the femoral vein presenting clinically as deep vein thrombosis: a case report

Subramaniam, Manish Mani; Martínez‐Rodríguez, Miguel; Navarro, Samuel; Rosaleny, Jorge Guijarro; Bosch, Antonio Llombart

doi:10.1007/s00428-006-0322-2

Cited by 19 publications

(10 citation statements)

References 6 publications

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“…To treat a tumor of vascular origin, revascularization is needed after thorough lymphadenectomy and dissection of the tumor (8)(9)(10)(11)(12). However, without an evident mass, as in the present case, it is difficult to perform biopsy for diagnosing a tumor.…”

Section: Discussionmentioning

confidence: 92%

“…Many such conditions are caused by thrombus in the vein (1) or external compression exerted by, e.g., a pelvic tumor (2,3) or the iliac artery (4-7), and definite diagnosis for these cases can be relatively easily made by imaging studies. Although rare, a vein can also become narrowed or occluded because of a sarcoma originating from the vein (8)(9)(10)(11)(12). In these cases of venous sarcoma, tumors could be discovered as a mass around the vein (8)(9)(10)(11)(12); in such a case, diagnosis of the tumor would be easy.…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, a vein can also become narrowed or occluded because of a sarcoma originating from the vein (8)(9)(10)(11)(12). In these cases of venous sarcoma, tumors could be discovered as a mass around the vein (8)(9)(10)(11)(12); in such a case, diagnosis of the tumor would be easy. However, the present case does not match any of these cases; percutaneous ultrasound, CT, angiography, and IVUS could not detect a definite mass around the stenotic segment of the vein, and thickening of the vein wall was not observed.…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, primary venous tumors have also been reported as the cause of stenosis or occlusion of a vein (8)(9)(10)(11)(12). We encountered a case in which lung metastasis led to a diagnosis of a sarcoma originating from the iliac vein two years after stent placement to treat right iliac vein stenosis of unknown etiology, for which imaging studies provided no findings suggesting a tumor.…”

Section: Introductionmentioning

confidence: 99%

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A Case in Which Sarcoma Was Diagnosed Two Years after Stent Placement to Treat Right Iliac Vein Stenosis that Accompanied Severe Unilateral Leg Edema

Shinozaki

Kawaguchi

2012

Intern. Med.

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A 70-year-old man complained of right leg swelling due to right iliac vein stenosis. No mass was identified around the stenotic site, and the vessel wall had not become thickened. Self-expandable stents were positioned at the stenotic site. About two years later, chest CT revealed lung nodules. Pathology showed sarcoma. A mass that was considered to be the primary lesion was found around the stent in the right iliac vein. Although sarcoma of the iliac vein is very rare, it should be considered in the differential diagnosis of iliac vein stenosis, even if there are no suspicious findings from image studies.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Case in Which Sarcoma Was Diagnosed Two Years after Stent Placement to Treat Right Iliac Vein Stenosis that Accompanied Severe Unilateral Leg Edema

Shinozaki

Kawaguchi

2012

Intern. Med.

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“…Clinical manifestations depend on the tumor position in the vessel wall, venous obstruction and compression of the surrounding organs by the mass, including palpable abdominal masses and symptoms associated with thrombosis or embolism of the splenic vein, such as abdominal pain, nausea and fever (9,10). Sarcomas of the great vessels are classified into luminal and mural tumors according to their site of origin (5).…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the splenic vein: A case report

Zhao

Wang

et al. 2017

Oncology Letters

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Abstract. Leiomyosarcomas (LMSs) originating from the wall of blood vessels are aggressive and rare neoplasms. The current study describes a case of a 52-year-old man who presented with intermittent abdominal pain without weight loss or diarrhea. Computed tomography of the abdomen identified a 4-cm, solid, heterogeneous tumor in the tail of the pancreas, while a hypodense lesion was also noted in the right hepatic lobe. The patient subsequently underwent splenic pedicle tumor resection, splenectomy and liver tumor resection. Notably, immunohistochemical and histological analyses identified LMS, which had originated from the smooth muscle of the splenic vein. Currently available information regarding LMSs of the splenic vein and their management is also discussed, with the aim of improving diagnostic accuracy. IntroductionPrimary leiomyosarcoma (LMS) of the splenic vein is a rare malignant tumor and there have only been three previously reported cases (1,2). Due to the rarity of the tumor, its imaging features have not yet been described in detail. Venous LMSs predominately occur in middle-aged women in the fifth and sixth decades of life (3). Clinical manifestations depend on the tumor position in the vessel wall (4). The symptoms of LMS include abdominal masses, abdominal pain, nausea and fever (5). The current study presents a case report on the magnetic resonance imaging (MRI) features of primary LMS of the splenic vein. A solid, heterogeneous mass was located in the tail of the pancreas. In portal phase, the splenic vein was embedded in the mass on T1-weighted imaging (T1WI). The patient underwent splenic pedicle tumor resection, splenectomy and liver tumor resection with no postoperative complications.There is a limited amount of evidence demonstrating increased survival following adjuvant radiation, combination radiation and chemotherapy, in addition to surgical resection (6). Further information regarding the prognosis of the present patient is unavailable, as the patient did not undergo further adjuvant therapy or follow-up, and unique treatment recommendations or outcome data for such lesions remains to be established. Case reportIn June 2013, a 52-year-old male was admitted to the Gastroenterology Department of The Second Affiliated Hospital of Kunming Medical University (Kunming, China) presenting with a long history (>1 year) of intermittent epigastric pain. The pain presented as either severe colic lasting for 20-30 min or as dull pain, which would be relieved following squatting. The medical history of the patient was unremarkable. A whole body positron emission tomography scan was performed at Yuxi People's Hospital (Yuxi, China) and revealed an irregular mass in the splenic hilum without increased metabolism.An abdominal computed tomography (CT) scan performed at the Department of Radiology, The Second Affiliated Hospital of Kunming Medical University identified an irregular, hypodense mass measuring ~4.1x3.0 cm in the tail of the pancreas, while a hypodense lesion was also observed in the right ...

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Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report

et al. 2014

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Soft tissue tumors arising in deep veins of the extremities are uncommon, although a few cases of synovial sarcoma or leiomyosarcoma arising in the femoral vein have been documented. However, to the best of our knowledge, an extraskeletal myxoid chondrosarcoma (EMC) arising in the femoral vein has not been reported in the English literature. We report a case of EMC arising in the femoral vein of a 70-year-old man who presented with right leg edema and was diagnosed with a deep venous thrombosis (DVT) by computed tomography (CT). Magnetic resonance imaging (MRI) revealed a mass in the right proximal thigh that was diagnosed as myxomatous sarcoma by aspiration cytology, and anticoagulant therapy was initiated. The mass was surgically resected en bloc, including the femoral vein and surrounding soft tissue, and the femoral artery was preserved. The femoral vein was not reconstructed. The histologic diagnosis was an extraskeletal myxoid chondrosarcoma. The patient received postoperative local radiation treatment, with a total dose of 60 Gy, and is currently doing well with no evidence of local recurrence or metastasis at 8 months after surgery. In summary, this case report shows that EMC can arise in the femoral vein, and that reconstruction of the femoral vein is not always necessary during surgery for soft tissue tumors.

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Primary intravascular myxoid leiomyosarcoma of the femoral vein presenting clinically as deep vein thrombosis: a case report

Cited by 19 publications

References 6 publications

A Case in Which Sarcoma Was Diagnosed Two Years after Stent Placement to Treat Right Iliac Vein Stenosis that Accompanied Severe Unilateral Leg Edema

A Case in Which Sarcoma Was Diagnosed Two Years after Stent Placement to Treat Right Iliac Vein Stenosis that Accompanied Severe Unilateral Leg Edema

Leiomyosarcoma of the splenic vein: A case report

Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report

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