Primary Isoniazid Resistance In Mycobacterium Bovis Disease: A Disturbing Prospect

McLaughlin, Anne Marie; Power, Joan; Foley, Susan; Keane, Joseph

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6747

Cited by 5 publications

(6 citation statements)

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“…caprae is a human pathogen [16] and consumption of unpasteurized dairy products from animals with lesions in the mammary glands is a public health risk [25]. Also, in the light of the recent studies that proved the ability of zoonotic variants of M. tuberculosis (bovis and caprae) to acquire antimicrobial resistance due to treatment of humans with TB [4,14,18], the confirmatory diagnosis should include the antimicrobial resistance (AMR) profile of each strain not only in humane tuberculosis, but also in bovine tuberculosis. Considering the DR-TB as a serious threat to global control of TB [20], the detection of multi-drug resistance (MDR-TB), extensively drug resistance (XDR-TB) and totally drug-resistant (TDR) strains in the veterinary laboratory can prevent the emergence of zoonotic DR-TB.…”

Section: Resultsmentioning

confidence: 99%

Management of the Bovine Tuberculosis Diagnostic in Romanian Farms, in the Light of the Multidrug-Resistant Tuberculosis Emergence

Bărbuceanu¹

2020

FARMACIA

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Tuberculosis (TB) is still a public health concern in numerous countries. Livestock can plays an important role in the global control of TB and, consequently, the prevention of tuberculosis in farm animals is an important goal. This study shows the relevance of the diagnostic of the infections produced by Mycobacterium spp. in Romanian slaughtered cattle and consider the opportunity of antimycobacterial susceptibility testing in a veterinary laboratory. Phenotyping and genotyping of the Mycobacterium isolates between 2015 and 2016, revealed 567 strains of M. tuberculosis var. caprae and 22 strains of M. tuberculosis var. bovis. These data support the risk of TB emergence in cattle herds and the human population with M. tuberculosis var. caprae. RezumatTuberculoza (TB) continuă să fie o problemă de sănătate publică în numeroase țări. Șeptelul poate juca un rol important în controlul global al tuberculozei, iar prevenirea tuberculozei în fermele de animale este un obiectiv major. Acest studiu prezintă diagnosticul de laborator al infecțiilor cu Mycobacterium spp. la bovinele din România și analizează oportunitatea introducerii testului de sensibilitate la antimicobacteriene în laboratorul veterinar. Tipizarea izolatelor de Mycobacterium din perioada 2015 -2016 a stabilit că 567 tulpini erau M. tuberculosis var. caprae și 22 M. tuberculosis var. bovis. Aceste date susțin riscul emergenței tuberculozei bovine și umane cu M. tuberculosis var. caprae.

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Section: Resultsmentioning

confidence: 99%

Management of the Bovine Tuberculosis Diagnostic in Romanian Farms, in the Light of the Multidrug-Resistant Tuberculosis Emergence

Bărbuceanu¹

2020

FARMACIA

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“…While it is not rare in M. tuberculosis , further studies targeting this mutation in M. bovis might provide more insight into this mechanism of resistance in this species. Similarly, isoniazid (INH) resistance, though less common, has been demonstrated from animal-recovered isolates and is a cause for concern [ 82 , 83 , 84 , 85 ]. INH resistance can be associated with mutations in several genes ( fabG1 , inhA , iniC , kasA , and katG ); here, the five genomes with this predicted mutation involved fabG1 .…”

Section: Discussionmentioning

confidence: 99%

Whole-Genome SNP Analysis Identifies Putative Mycobacterium bovis Transmission Clusters in Livestock and Wildlife in Catalonia, Spain

et al. 2021

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The high-resolution WGS analyses of MTBC strains have provided useful insight for determining sources of infection for animal tuberculosis. In Spain, tuberculosis in livestock is caused by Mycobacterium bovis and Mycobacterium caprae, where wildlife reservoirs play an important role. We analyzed a set of 125 M. bovis isolates obtained from livestock and wildlife from Catalonia to investigate strain diversity and identify possible sources and/or causes of infection. Whole-genome SNP profiles were used for phylogenetic reconstruction and pairwise SNP distance analysis. Additionally, SNPs were investigated to identify virulence and antimicrobial resistance factors to investigate clade-specific associations. Putative transmission clusters (≤12 SNPs) were identified, and associated epidemiological metadata were used to determine possible explanatory factors for transmission. M. bovis distribution was heterogeneous, with 7 major clades and 21 putative transmission clusters. In order of importance, the explanatory factors associated were proximity and neighborhood, residual infection, livestock-wildlife interaction, shared pasture, and movement. Genes related to lipid transport and metabolism showed the highest number of SNPs. All isolates were pyrazinamide resistant, and five were additionally resistant to isoniazid, but no clade-specific associations could be determined. Our findings highlight the importance of high-resolution molecular surveillance to monitor bovine tuberculosis dynamics in a low-prevalence setting.

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“…In some countries it may be illegal. Few cases of acquired antimicrobial resistance are described in the literature on M. bovis or M. caprae isolated from human cases (Armstrong and Christie, ; McLaughlin et al., ) and these may have been a result of selection of resistance due to treatment of humans infected with M. bovis (Guerrero et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bovine tuberculosis

More¹,

Bøtner²,

Butterworth³

et al. 2017

EFS2

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Bovine tuberculosis has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of bovine tuberculosis to be listed, Article 9 for the categorisation of bovine tuberculosis according to disease prevention and control rules as in Annex IV and Article 8 on the list of animal species related to bovine tuberculosis. The assessment has been performed following a methodology composed of information collection and compilation, expert judgement on each criterion at individual and, if no consensus was reached before, also at collective level. The output is composed of the categorical answer, and for the questions where no consensus was reached, the different supporting views are reported. Details on the methodology used for this assessment are explained in a separate opinion. According to the assessment performed, bovine tuberculosis can be considered eligible to be listed for Union intervention as laid down in Article 5(3) of the AHL. The disease would comply with the criteria as in Sections 2, 3, 4 and 5 of Annex IV of the AHL, for the application of the disease prevention and control rules referred to in points (b), (c), (d) and (e) of Article 9(1). The main animal species to be listed for bovine tuberculosis according to Article 8(3) criteria are several mammal species, as indicated in the present opinion.

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Primary Isoniazid Resistance In Mycobacterium Bovis Disease: A Disturbing Prospect

Cited by 5 publications

References 0 publications

Management of the Bovine Tuberculosis Diagnostic in Romanian Farms, in the Light of the Multidrug-Resistant Tuberculosis Emergence

Management of the Bovine Tuberculosis Diagnostic in Romanian Farms, in the Light of the Multidrug-Resistant Tuberculosis Emergence

Whole-Genome SNP Analysis Identifies Putative Mycobacterium bovis Transmission Clusters in Livestock and Wildlife in Catalonia, Spain

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bovine tuberculosis

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