Primary Large B-Cell Lymphoma of the Base of Tongue

Busoni, Michele

doi:10.15406/joentr.2015.03.00081

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…[12] Some patients have later-stage symptoms, such as fever, night sweats, or significant weight loss. [5,7] International Journal of Scientific Advances ISSN: 2708-7972…”

Section: Discussionmentioning

confidence: 99%

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Challenges in the Diagnosis of Extranodal Non-Hodgkin’s Lymphoma of the Base of Tongue: A Rare Case Report

Prabawa,

Rena

2023

International Journal of Scientific Advances

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Introduction: Primary non-Hodgkin’s lymphomas (NHLs) of the oral cavity, especially in the tongue, are extremely rare and account for 1% of all malignant tumors of the oral cavity, accounting for 7% of all primary Waldeyer’s ring NHLs. Clinical features are non-specific ulcerative lesions that do not heal, making its diagnosis challenging. Fine-needle aspiration biopsy was helpful in the early diagnosis of the intraoral NHL involving a cervical lymph node. Case Report: we present a rare case of extranodal NHL of the base of tongue in a 55-year-old female who presented with a mass in the base of the tongue with cervical lymphadenopathy. The diagnosis was confirmed as primary NHL diffuse large B cell type by histopathological and immunohistochemistry results. Conclusion: A careful clinical evaluation supported by histopathological and radiologic investigations will help identify the disease early, resulting in a better prognosis.

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“…[12] Some patients have later-stage symptoms, such as fever, night sweats, or significant weight loss. [5,7] International Journal of Scientific Advances ISSN: 2708-7972…”

Section: Discussionmentioning

confidence: 99%

“…[3,4] NHL at the base of tongue affects patients between the fourth and eighth decades of life, with a mean age between 50 and 60 years. [5,6] Diagnosis of lymphoma in the oral cavity, especially the base of tongue, can be complicated by the low level of clinical suspicion.…”

Section: Introductionmentioning

confidence: 99%

Challenges in the Diagnosis of Extranodal Non-Hodgkin’s Lymphoma of the Base of Tongue: A Rare Case Report

Prabawa,

Rena

2023

International Journal of Scientific Advances

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“…This case is unique, given the lack of evidence of disseminated MCL involvement, heightening the likelihood of local progressive disease as the cause of the symptomatic TGDC. 11-15 MCL possesses a histologically distinct phenotype with diffuse, monotonous and/or nodular proliferation of small-medium sized cells characterized by cyclin-D1 overexpression, triggering the hyperphosphorylation of the retinoblastoma tumor suppressor, and the subsequent erosion of the G1-S cell-cycle check point. 11 Thus, MCL can be distinguished from other morphologically types of NHL by diffuse overexpression of cyclin-D1 as well as other surface markers including CD20 and aberrant expression of CD5.…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Thyroglossal Duct Cyst Presenting With Synchronous and Localized Tongue Base Extranodal Mantle Cell Lymphoma. A Unique Case Report Demonstrating Lymphoma Colonization of Cyst Wall, Potentially Relating to a Persistent Embryological Foramen Cecum Remnant

et al. 2021

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A 77-year-old male presented with a progressively enlarging midline neck mass. On further investigation he was found to have synchronous thyroglossal duct cyst and extranodal mantle cell lymphoma (MCL) localized to the base of tongue. Both pathologies were managed simultaneously with a surgical approach and the patient remained in clinical remission at the time of publication without indication for systemic oncological treatment. Histology revealed primary extranodal nonblastoid MCL forming a base of tongue mass, with colonization of the thyroglossal duct cyst. Lymphoma was also found in the epithelium of a crypt-like tract traversing one of the tongue base tumor sections. This tract was anatomically and histologically consistent with documented descriptions of the foramen cecum. This case report illustrates a previously undescribed temporal, clinical, and histological association between a base of tongue MCL and symptomatic thyroglossal duct cyst. We provide evidence for a potential causal relationship for the presentation of the thyroglossal duct cyst as a result of oropharyngeal MCL, in the absence of clinical and histological evidence of disseminated disease, directly infiltrating from its tongue base origin to the infrahyoid neck region, potentially via an embryologic foramen cecum remnant. We also highlight the crucial role of the histopathologist in multidisciplinary clinicopathological discussion in demonstrating how fundamental embryological and microanatomical relationships can unite apparently separate diseases.

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Primary Large B-Cell Lymphoma of the Base of Tongue

Cited by 2 publications

References 12 publications

Challenges in the Diagnosis of Extranodal Non-Hodgkin’s Lymphoma of the Base of Tongue: A Rare Case Report

Challenges in the Diagnosis of Extranodal Non-Hodgkin’s Lymphoma of the Base of Tongue: A Rare Case Report

Symptomatic Thyroglossal Duct Cyst Presenting With Synchronous and Localized Tongue Base Extranodal Mantle Cell Lymphoma. A Unique Case Report Demonstrating Lymphoma Colonization of Cyst Wall, Potentially Relating to a Persistent Embryological Foramen Cecum Remnant

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