Primary laryngeal localization of multiple myeloma: A case report

Abstract

Multiple myeloma is a lymphoproliferative disease that may involve the bone marrow as well as extramedullary soft tissues. However, laryngeal localization of multiple myeloma is extremely rare. We herein present the case of a 68-year-old male patient with a history of dyspnea, dysphonia and dysphagia. Laryngoscopic examination revealed a lesion involving the right glottis and right vestibular (false) vocal fold, with absence of ipsilateral laryngeal motility and constriction of the airway. Computed tomography and magnetic resonance imaging revealed a gross swelling infiltrating the right glottis and right false vocal fold, sized 33×19×33 mm, with sub-centimeter laterocervical lymph nodes bilaterally. Careful integration of the clinical manifestations with the radiological and pathological data led to the diagnosis of multiple myeloma. Given the rarity of this localization, the purpose of this study was to increase knowledge of this disease among ear, nose and throat specialists, in order to enable a more timely diagnosis.

A case of Multiple Myeloma with lung plasmacytoma

“…Extramedullary plasmacytoma is a monoclonal proliferation of plasma cells in soft tissues or an organ. It accounts for about 3% of plasma cell malignancies and approximately 80% of which, in the upper respiratory tract (commonly in oropharynx, paranasal sinuses [ 5 , 6 ] and more rarely in the larynx [ 7 ]). The relationship between multiple myeloma, solitary plasmacytoma of the bone, and extramedullary plasmacytoma is not well understood.…”

Rare Differential Diagnosis of Dyspnea: Extramedullary Plasmocytoma (EMP) of the Larynx—Case Report and Review of the Latest Literature of Laryngeal EMP and Laryngeal Involvement of Multiple Myeloma

“…In two of the ten cases, a MM had been known in the patient's history [3, 22]. In four of the remaining eight cases, the pathologic clinical findings in the larynx led to the diagnosis of MM [20, 21, 25, 26]. In one of the remaining four cases, additionally to the findings in the larynx, there was a solitary plasmacytoma of the rib [24].…”

“…As far as therapy is concerned, it is the experience of the published cases in the last five years that the patients with preknown MM benefit from local treatment with radiation therapy and subsequent systemic therapy [3, 22]. Patients with newly diagnosed MM were systemically treated [20, 21], whereas in patients with EMP, surgery for local excision of tumor masses followed by radiotherapy was recommended [8, 23, 27].…”