Primary laryngeal natural killer/T‐cell lymphoma—Report of a rare case

Abstract

To the best of our knowledge, this is the second case of primary laryngeal NK/T-cell that illustrates its clinical picture. In the early stage of the disease, this type of tumor can present as granulous tumor-like lesion without a definite destructive lesion. This tumor type should be kept in mind in tumors that are difficult to diagnose, especially in Asian populations.

Primary laryngeal lymphoma: Report of 3 cases and review of the literature

“…MALT lymphomas belong to the category of the extranodal marginal zone B‐cell lymphomas and usually arise in the stomach. The detection of a MALT lymphoma in larynx is very rare, and less than 15 cases have been reported since its first description by Diebold et al40, 42 In our department, the 2 cases had T‐cell type origin, and the rest B‐cell (MALT type).…”

“…Imaging techniques, such as CT scan and MRI, may be helpful for assessment of any laryngeal neoplasm,19, 41 although histopathological examination is essential for the final diagnosis. Especially for T/NK‐cell lymphomas, multiple deep biopsies are needed over a long period of time, as in early‐stage disease, the dispersed atypical lymphoid cells and the remarkable diversity of cellular infiltration do not enable to distinguish safely the neoplastic from inflammatory cells 5, 40…”

Anaplastic Lymphoma Kinase-positive Primary Diffuse Large B-cell Lymphoma of the Larynx: A Rare Clinical Entity

“…7 Deeper biopsies may be needed as superficial ones cannot distinguish safely the neoplastic from inflammatory cells. 26,27 Primary laryngeal lymphomas usually show a intact overlying mucosa, benign appearing mass which can be differentiated from squamous cell carcinoma but has irregularity and ulceration involving the free margins of the laryngeal structures. 28 Immunohistochemical analysis is required for accurate diagnosis as numerous antibodies are used to delineate the lymphoid nature of the cells and provide more specific information about the classification of B-cell or T-cell lineage subsets.…”

Lymphome malin non Hodgkinien primitif du larynx: à propos d’un cas

“…Elle permet d'obtenir une réponse complète prolongée pour 50 à 90% des patients atteints d'un lymphome stade I ou stade II localisé, mais compte tenu de la nature systémique de la plupart des cas, une chimiothérapie à base de CHOP associe ou non au rituximab selon le type histologique a une place importante, en particulier dans les cas de lymphomes de bas grade [6–9]. Le pronostic des LMNH primitifs du larynx et leur mode d’évolution se rapprochent des LMNH ganglionnaires (atteinte ganglionnaire sus et sous diaphragmatique, envahissement médullaire …).…”