Primary leiomyosarcoma of the greater omentum: a case report

Brañes, Alejandro; Bustamante, Caroll; Valbuena, José R.; Pimentel, Fernando; Quezada, Nicolás

doi:10.1016/j.ijscr.2016.10.025

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…The most common presenting symptom was abdominal mass followed by pain abdomen similar to the present case. Ascitis was also reported in few cases [2,3,6]. Our patient did not have ascitis.…”

Section: Discussionsupporting

confidence: 62%

“…Early reports showed poor outcomes with a high post-operative death rate. Given the poor prognosis of leiomyosarcoma, misdiagnosis may have a detrimental effect on patient outcome [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…Most of these cases originated from the greater omentum. These tumors are generally seen in the middle age [2,3]. These tumors can mimic other tumors like gastrointestinal stromal tumors (GIST) due to their common origin from mesenchymal stem cells [4].…”

Section: Introductionmentioning

confidence: 99%

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Primary Omental Leiomyosarcoma: A Rare Case Report

Bhandari

Jadhav

Patil

et al. 2017

Trop J Pathol Microbiol

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Primary leiomyosarcoma of greater omentum is rare and mimics gastrointestinal stromal tumor (GIST) due to their common origin. A 65 years old male presented with a large mass per abdomen of one year duration. Imaging findings were suggestive of extra-gastrointestinal stromal tumor (E-GIST) arising from greater omentum. The mass was excised. On microscopy, the diagnosis of leiomyosarcoma and E-GIST were considered. The tumor cells showed immunoreactivity for smooth muscle actin, muscle-specific actin, heavy-caldesmon and desmin and were immunonegative for CD117, DOG1 and CD34, hence confirming primary leiomyosarcoma of greater omentum. We present this case for its rarity.

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Section: Discussionsupporting

confidence: 62%

“…Early reports showed poor outcomes with a high post-operative death rate. Given the poor prognosis of leiomyosarcoma, misdiagnosis may have a detrimental effect on patient outcome [1,2].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Omental Leiomyosarcoma: A Rare Case Report

Bhandari

Jadhav

Patil

et al. 2017

Trop J Pathol Microbiol

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“…The greater omentum is a two-layered membrane that arises from the greater curvature of the stomach, extends down to cover the abdominal organs, and folds back to join the transverse colon [ 1 ]. This organ mainly comprises the peritoneal and adipose tissues and includes vessels and lymphoid tissue [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Notably, OALT has a significant impact on peritoneal carcinomatosis because it is also responsible for tumor cell filtration [ 4 – 6 ]. Therefore, most malignancies of the greater omentum are metastatic, and the incidence of primary tumors is rare [ 1 , 7 ]. Herein, we report a case of a primary smooth muscle tumor arising in the greater omentum in an adult male, along with its histological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Primary omental smooth muscle tumor in an adult male: a diagnostic dilemma for leiomyoma: a case report

Ono,

Okubo,

Washimi

et al. 2024

J Med Case Reports

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Background The greater omentum comprises peritoneal, adipose, vascular, and lymphoid tissues. Most omental malignancies are metastatic tumors, and the incidence of primary tumors is rare. We report on a prior omental smooth muscle tumor case in an adult male patient. Case presentation A 54-year-old Japanese male patient with no relevant medical history was diagnosed with an abdominal mass during a routine medical checkup. Subsequent contrast-enhanced computed tomography revealed a mass of approximately 3 cm in size in the greater omentum, and a laparotomy was performed. A 27 × 25 × 20 mm raised lesion was found in the omentum. Microscopically, spindle cells were observed and arranged in whorls and fascicles. Individual tumor cells had short spindle-shaped nuclei with slightly increased chromatin and were characterized by a slightly eosinophilic, spindle-shaped cytoplasm. The mitotic count was less than 1 per 50 high-power fields. The tumor cells showed positive immunoreactivity for α smooth muscle actin, HHF35, and desmin on immunohistochemical examination. The Ki-67 labeling index using the average method was 1.76% (261/14806). No immunoreactivity was observed for any of the other tested markers. We considered leiomyoma owing to a lack of malignant findings. However, primary omental leiomyoma has rarely been reported, and it can be difficult to completely rule out the malignant potential of smooth muscle tumors in soft tissues. Our patient was decisively diagnosed with a primary omental smooth muscle tumor considering leiomyoma. Consequently, the patient did not undergo additional adjuvant therapy and was followed up. The patient was satisfied with treatment and showed neither recurrence nor metastasis at the 13-month postoperative follow-up. Discussion and conclusion We encountered a primary smooth muscle tumor of the greater omentum with no histological findings suggestive of malignancy in an adult male patient. However, omental smooth muscle tumors are extremely difficult to define as benign, requiring careful diagnosis. Further case reports with long-term follow-up and case series are required to determine whether a true omental benign smooth muscle tumor (leiomyoma) exists. In addition, proper interpretation of the Ki-67 labeling index should be established. This case study is a foundation for future research.

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