Primary leiomyosarcoma of the mesentery in two sisters: clinical and molecular characteristics

Koczkowska, Magdalena; Lipska, Beata S.; Grzeszewska, Joanna; Limon, Janusz; Biernat, Wojciech; Jassem, Jacek

doi:10.5114/pjp.2013.34605

Cited by 14 publications

(15 citation statements)

References 6 publications

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“…Only 2 patients, including the one reported in this study, developed single liver metastasis (5). Three cases, including the patient reported in our study, underwent surgery for liver metastasis (6), and 3 cases received chemotherapy for the metastatic lesions (5,7). There is no mention of surgical intervention or chemotherapy treatment for the secondary liver lesions in the remaining 3 cases.…”

Section: Discussionmentioning

confidence: 90%

Curative resection for leiomyosarcoma of the descending mesocolon with metachronous liver metastasis: A case report and literature review

Kato

Noda

Abe

et al. 2016

Molecular and Clinical Oncology

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Mesenteric leiomyosarcoma is a rare disease with poor prognosis. Previously, mesenteric leiomyosarcoma was not differentiated from gastrointestinal stromal tumor (GIST), which is the most common mesenchymal tumor of the gastrointestinal tract, and several cases of GIST may have been misclassified as mesenteric leiomyosarcoma. Thus, the actual clinicopathological characteristics of mesenteric leiomyosarcomas remain unclear. We herein describe a case of leiomyosarcoma arising in the descending mesocolon in a patient who developed metachronous liver metastasis. A 76-year-old woman reported a mass in her left upper abdomen. Computed tomography imaging revealed a low-density tumor adjacent to the descending colon. The patient underwent surgery and the tumor was resected along with part of the descending colon. Immunohistochemical differential diagnosis revealed that the tumor was positive for smooth muscle actin and desmin, and negative for CD117 (c-KIT) and S-100, which are characteristic of gastrointestinal leiomyosarcoma. A single liver metastasis developed 24 months after the operation. The patient underwent curative resection of the metastatic lesion. Sixteen months following surgery for the liver metastasis and 40 months after the initial removal of the primary lesion, the patient remains disease-free. The prognosis of leiomyosarcoma remains poor and standardized chemotherapy for this rare disease has not yet been established. Early diagnosis and surgical removal of the tumor is the only potentially curative option for liver metastasis of mesenteric leiomyosarcoma.

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Section: Discussionmentioning

confidence: 90%

Curative resection for leiomyosarcoma of the descending mesocolon with metachronous liver metastasis: A case report and literature review

Kato

Noda

Abe

et al. 2016

Molecular and Clinical Oncology

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“…Koczkowska M (2013) [6] 46-year-old female; detected during surgery for uterine myoma Surgical resection Recurrences at 6 and 9 months; died after 4 years and 10 months of initial diagnosis Sidhic AK (2015) [11] 33-year-old male; abdominal pain Surgical resection Not mentioned Present study (2015) 62-year-old female; heaviness and fullness of the abdomen Surgical resection, no radiotherapy or chemotherapy…”

Section: Discussionmentioning

confidence: 95%

“…Cappellani A et al presented a case of mesocolic and duodenal leiomyosarcoma with muscular metastases [5]. Interestingly, Koczkowska M et al reported two sisters who presented with primary mesenteric leiomyosarcomas, raising questions about familial occurrence of the tumor [6].…”

Section: Discussionmentioning

confidence: 98%

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Ileal Mesenteric Leiomyosarcoma—Report of a Rare Neoplasm

Dasgupta

Chakrabarti

Ghosh

et al. 2015

J Gastrointest Canc

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“…The surgery is a mainstay of treatment for this type of tumour as it is notoriously resistant to radiotherapy and chemotherapy 15. Earlier detection by CT together with complete oncological resection may improve long-term prognosis in patients with primary leiomyosarcoma of mesenteric origin 16.…”

Section: Discussionmentioning

confidence: 99%

Rare case of primary leiomyosarcoma of sigmoid mesocolon

et al. 2017

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We experienced a rare case of primary leiomyosarcoma of sigmoid mesentery. A 45-year-old woman was presented to us with left iliac fossa mass and discomfort for 4-month duration. CT scan of abdomen and pelvis revealed a huge mass 14 cm×14 cm×16 cm occupying left iliac fossa mimicked having a large left ovarian carcinoma. She was subsequently planned for elective total abdominal hysterectomy and bilateral salpingo-oophorectomy by gynaecology team. During laparotomy, a huge mass was revealed arising from sigmoid mesentery invaded to the left lower ureter. Curative resection was done and pathological findings show the tumour being leiomyosarcoma with immunohistochemistry tests on caldesmon, desmin, smooth muscle actin and CD34 reagent all positive. Clinicopathological and literature review of this rare primary leiomyosarcoma of mesocolon was discussed in our case presentation.

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Primary leiomyosarcoma of the mesentery in two sisters: clinical and molecular characteristics

Cited by 14 publications

References 6 publications

Curative resection for leiomyosarcoma of the descending mesocolon with metachronous liver metastasis: A case report and literature review

Curative resection for leiomyosarcoma of the descending mesocolon with metachronous liver metastasis: A case report and literature review

Ileal Mesenteric Leiomyosarcoma—Report of a Rare Neoplasm

Rare case of primary leiomyosarcoma of sigmoid mesocolon

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