Primary Liver Cancer in Cirrhosis of the Alcoholic*

Leevy, Carroll M.; Gellene, Rosemary A.; Ning, May

doi:10.1111/j.1749-6632.1964.tb41022.x

Cited by 49 publications

(1 citation statement)

References 16 publications

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“…However, we did not previously consider a crucial prognostic factor, tumor encapsulation. Encapsulated HCCs exhibit a grossly distinct capsule-like fibrous tissue surrounding well-differentiated tumors, and are associated with a protracted clinical course and increased survival 31. We assessed macroH2A1 and CD44 expression by immunohistochemical labeling of HCC biopsies from patients with encapsulated or non-encapsulated tumors (n=10 per group) (Figure 1A and B) (Supplemental Table 2).…”

Section: Resultsmentioning

confidence: 99%

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4⁺CD25⁺FoxP3⁺ regulatory T cells activation

Re¹,

Mazza²,

Giallongo³

et al. 2020

Theranostics

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Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear.Methods: We screened aggressive human HCC for macroH2A1 and CD44 CSC marker expression. We also knocked down (KD) macroH2A1 in HCC cells, and performed integrated transcriptomic and secretomic analyses.Results: Human HCC showed low macroH2A1 and high CD44 expression compared to control tissues. MacroH2A1 KD CSC-like cells transferred paracrinally their chemoresistant properties to parental HCC cells. MacroH2A1 KD conditioned media transcriptionally reprogrammed parental HCC cells activated regulatory CD4+/CD25+/FoxP3+ T cells (Tregs).Conclusions: Loss of macroH2A1 in HCC cells drives cancer stem-cell propagation and evasion from immune surveillance.

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Section: Resultsmentioning

confidence: 99%

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4⁺CD25⁺FoxP3⁺ regulatory T cells activation

Re¹,

Mazza²,

Giallongo³

et al. 2020

Theranostics

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Cirrhosis and hepatoma occurring at Boston city hospital (1917-1968)

Purtilo

Gottlieb

1973

Cancer

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A minute hepato cellular carcinoma found in a liver with clonorchis sinensis infection.Report of two cases

Nakashima¹,

Sakamoto²,

Okuda³

1977

Cancer

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Two cases of minute hepatocellular carcinoma (HCC) found in a liver infested with Clonorchis sinensis are described. One had mild infestation with hepatic changes suggestive of posthepatitic cirrhosis, and the other heavy infestation exhibiting secondary biliary cirrhosis with dilated intrahepatic bile ducts and periductal fibrosis. None had evidence of hepatitis B infection. The tumor nodule was solitary, measuring 5 X 7 mmand 10 X 11 mm, respectively,and the cells were differentiated to be classified as Grade I of Edmondson-Steiner's scale of anaplasia. It is not clear whether or not clonorchiasis was etiologically related to HCC, but it was of interest that in both cases the tumor nodule was very small representing the primary lesion without metastasis.

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Primary Liver Cancer in Cirrhosis of the Alcoholic*

Cited by 49 publications

References 16 publications

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4⁺CD25⁺FoxP3⁺ regulatory T cells activation

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4⁺CD25⁺FoxP3⁺ regulatory T cells activation

Cirrhosis and hepatoma occurring at Boston city hospital (1917-1968)

A minute hepato cellular carcinoma found in a liver with clonorchis sinensis infection.Report of two cases

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Primary Liver Cancer in Cirrhosis of the Alcoholic*

Cited by 49 publications

References 16 publications

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation

Cirrhosis and hepatoma occurring at Boston city hospital (1917-1968)

A minute hepato cellular carcinoma found in a liver with clonorchis sinensis infection.Report of two cases

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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4⁺CD25⁺FoxP3⁺ regulatory T cells activation

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4⁺CD25⁺FoxP3⁺ regulatory T cells activation