Primary liver cancer incidence among American Indians and Alaska Natives, US, 1999-2004

Jim, Melissa A.; Perdue, David G.; Richardson, Lisa C.; Espey, David K.; Redd, John T.; Martin, Howard J.; Kwong, Sandy; Kelly, Janet J.; Henderson, Jeffrey A.; Ahmed, Faruque

doi:10.1002/cncr.23728

Cited by 19 publications

(16 citation statements)

References 54 publications

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“…African Americans and Asians have demonstrated two- to four-fold higher HCC incidence than whites (16, 17). Native Americans and Alaskan Natives have increasing incidences of HCC (18). While some degree of the differential incidence may be biologically driven, lower utilization of surgical therapy (24–27% less often than white patients) exacerbates disparities in time to diagnosis (15).…”

Section: Racial/ethnic Variation In Treatment Of Chronic Liver Diseasementioning

confidence: 99%

Race and Ethnicity in Access to and Outcomes of Liver Transplantation: A Critical Literature Review

Mathur

Sonnenday

Merion

2009

American Journal of Transplantation

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Racial/ethnic disparities in access to and outcomes of liver transplantation are an important topic given the increasing diversity in the United States. Most reports on this topic predate the advent of allocation based on the Model for End-stage Liver Disease (MELD). For many patients with a variety of lethal conditions, liver transplantation is the only effective therapy, signifying the importance of equitable access to care. Racial/ethnic disparities have been described at various steps of the liver transplant process, including liver disease prevalence and treatment, access to a transplant center and its waitlist, receipt of a liver transplant, and post-transplant outcomes. The purpose of this mini-review is to critically evaluate the published literature on racial/ethnicity-based disparities in liver disease prevalence and treatment, transplant center referral, transplant rates, and post-transplant outcomes. We identify the shortcomings of previous reports and detail the barriers to completing properly constructed analyses, particularly emphasizing deficits in requisite data and the need for improved study design. Understanding the nature of race/ethnicity-based disparities in liver transplantation is necessary to improve research initiatives, policy design, and serves the broader responsibility of providing the highest quality care to all patients with liver disease.

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Section: Racial/ethnic Variation In Treatment Of Chronic Liver Diseasementioning

confidence: 99%

Race and Ethnicity in Access to and Outcomes of Liver Transplantation: A Critical Literature Review

Mathur

Sonnenday

Merion

2009

American Journal of Transplantation

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“…Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer deaths worldwide, and its incidence is increasing [1][2][3][4][5][6][7]. Approximately 70 to 80 % of HCC patients have unresectable tumor when diagnosis is confirmed [8].…”

Section: Introductionmentioning

confidence: 99%

Combination of individualized local control and target-specific agent to improve unresectable liver cancer managements: a matched case-control study

Zhang

Yang

et al. 2014

Targ Oncol

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Management of late-stage hepatocellular carcinoma is difficult. A direct comparison of clinical data is needed in order to demonstrate the survival benefits of different therapies. We directly compared various therapies in a retrospective matched case-control study. A total of 79 patients with unresectable tumors greater than 10 cm in size were included in the study between 2008 and 2012. Thirty-five patients were treated with transarterial chemoembolization for local control, 20 were treated with sorafenib systemic chemotherapy, and 24 received combination treatment. The total follow-up time after initial therapy was 4.5 years. Survival time after treatment was significantly longer in the combination therapy group (P < 0.0001). The median survival times for combination, local control, and systemic chemotherapy were 15 (12-21), 10 (9-13), and 3.5 (2.5-9.0) months (95 % confidence interval), respectively. The hazard ratios for local control and systemic chemotherapy were 1.985 and 5.102, respectively, with combination treatment as the reference. There was no observed difference in combination therapy from the side effects of the individual therapies. In conclusion, the limited availability of therapeutic options for late-stage liver cancer necessitates reliance on multidisciplinary personalized medicine approaches with target-specific medications to increase survival time. Combining individualized local control therapy and drugs that target specific disease markers provides more benefits to patients.

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“…Females demonstrated an excess of liver cancer between 1990 and 2004. While hepatobiliary cancers have been generally increased among AI populations, 3,5,6,8–10,17,25 it is difficult to assess the significance of this observation in the present study based on a limited number of cases. Multiple risk factors for liver cancer have been identified and the presence of these risk factors among these cases is unknown.…”

Section: Discussionmentioning

confidence: 85%

Changes in Cancer Incidence Patterns Among a Northeastern American Indian Population: 1955‐1969 Versus 1990‐2004

Mahoney

Stevens³

et al. 2009

The Journal of Rural Health

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Primary liver cancer incidence among American Indians and Alaska Natives, US, 1999-2004

Cited by 19 publications

References 54 publications

Race and Ethnicity in Access to and Outcomes of Liver Transplantation: A Critical Literature Review

Race and Ethnicity in Access to and Outcomes of Liver Transplantation: A Critical Literature Review

Combination of individualized local control and target-specific agent to improve unresectable liver cancer managements: a matched case-control study

Changes in Cancer Incidence Patterns Among a Northeastern American Indian Population: 1955‐1969 Versus 1990‐2004

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