Primary liver leiomyosarcoma: CT appearance

Ferrozzi, F; Bova, Davide; Zangrandi, Adriano; Garlaschi, Giacomo

doi:10.1007/s002619900034

Cited by 41 publications

(30 citation statements)

References 6 publications

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“…The CT findings of PHL reveal a large, well-defined and heterogeneous hypodensity mass with internal and peripheral enhancement (13), or a cystic mass with an enhanced thickened wall (1,14). In the present case, the plain CT scan showed two well-defined masses with heterogeneous hypodensity in the caudate lobe and the left lobe of the liver; multiple satellite lesions were also observed in the remaining portion of the liver.…”

Section: Discussionmentioning

confidence: 51%

“…In total, <50 patients with PHL were reported in the English literature up until 2011. Among these patients, only five cases were involved in radiological studies (1)(2)(3)(4)(5). PHL may develop from the smooth muscle cells of intrahepatic vascular structures, bile ducts or ligamentum teres (1,3).…”

Section: Introductionmentioning

confidence: 99%

“…Among these patients, only five cases were involved in radiological studies (1)(2)(3)(4)(5). PHL may develop from the smooth muscle cells of intrahepatic vascular structures, bile ducts or ligamentum teres (1,3). It is difficult to obtain an early diagnosis due to the rarity, and non-specific conventional imaging manifestations and clinical presentation (6).…”

Section: Introductionmentioning

confidence: 99%

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Imaging features of primary hepatic leiomyosarcoma: A case report and review of literature

Han

Cheng

et al. 2015

Oncology Letters

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Abstract. Primary hepatic leiomyosarcoma (PHL) is an extremely rare tumour. This tumour is difficult to diagnose by imaging examinations due to its rarity, and non-specific conventional imaging manifestations and clinical presentation. The present study reports the case of a 42-year-old male with PHL that was confirmed by histopathological and immunohistochemical examinations. Multimodal imaging examinations, including ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT and digital subtraction angiography, were performed. The imaging manifestations were analysed and the associated literature was reviewed. The results found that no characteristic imaging appearance was present on ultrasound or plain CT scan. However, on unenhanced MRI, the tumours presented with a heterogeneous low signal density on T1-weighted imaging (WI) and a high signal density on T2WI and diffusion-WI. On gadopentetate dimeglumine enhanced MRI, the lesions were not enhanced during the arterial and portal venous phases; by contrast, these lesions were evidently enhanced during the 5-min delayed phase. Therefore, the delayed imaging of enhanced MRI is likely to be used to differentiate PHL from other hepatic tumours. IntroductionPrimary hepatic leiomyosarcoma (PHL) is an exceedingly rare tumour. In total, <50 patients with PHL were reported in the English literature up until 2011. Among these patients, only five cases were involved in radiological studies (1-5). PHL may develop from the smooth muscle cells of intrahepatic vascular structures, bile ducts or ligamentum teres (1,3). It is difficult to obtain an early diagnosis due to the rarity, and non-specific conventional imaging manifestations and clinical presentation (6). Imaging examinations play a significant role in detecting and differentiating the hepatic masses (7). The present study reports the case of a middle-aged male with PHL. The patient was subjected to multimodal imaging examinations, including ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT) and digital subtraction angiography (DSA). The imaging manifestations were analysed and the associated literature was reviewed. Case reportIn July 2013, a 42-year-old male presented to the First Affiliated Hospital of Shandong University (Jinan, China) with abdominal pain, marasmus and weakness that had persisted for two months. A physical examination revealed a notable hepatomegaly extending ~3 cm below the right costal margin. The patient had no medical history of previous liver diseases or alcohol abuse. Laboratory analysis showed normal liver and kidney functions. Other laboratory tests, including red blood cell, white blood cell and platelet counts, and hepatitis B surface antigen, hepatitis C virus antibody, α-fetoprotein, carbohydrate antigen 19-9 and carcinoembryonic antigen analysis, were normal.Abdominal ultrasonography (ClearVue 350; Philips Medical Systems, Best, the Netherlands) revealed two well-defined hetero...

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Imaging features of primary hepatic leiomyosarcoma: A case report and review of literature

Han

Cheng

et al. 2015

Oncology Letters

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“…Previous reports have described the development of PHL in patients with Hodgkin's lymphoma [6,7], gastric nonHodgkin's lymphoma [8], hereditary retinoblastoma [9], immunosuppression due to renal or liver transplantation [10,11], von Recklinghausen's disease [12], cirrhosis due to hepatitis C virus [13], Behcet's disease [14], acquired immunodeficiency syndrome [15][16][17][18], EBV [11,17], use of Thorotrast [19], and multiple cancers [20].…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic leiomyosarcoma in a patient with autosomal dominant polycystic kidney disease

et al. 2017

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“…A large, well-defined, heterogeneous hypodense mass with internal and peripheral enhancement or cystic mass with an enhancing thick wall may be seen on CT scan [7,8,9]. Immunohistochemistry will stain positive for desmin, vimentin and smooth muscle actin (SMA) will be present but will not stain for cytokeratin, S-100 protein, and neuron-specific enolase [9].…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Leiomyosarcoma A Space Occupying Lesion in the Liver: An Enigma for Diagnosis

More¹,

Shera²,

Patel³

et al. 2017

JGPLD

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Primary liver leiomyosarcoma: CT appearance

Abstract: Primary hepatic leiomyosarcomas are exceedingly rare tumors. To the best of our knowledge, only 17 cases have been reported in literature. We report the computed tomographic findings of two cases of primary location in the liver. We also discuss the differential diagnosis of such lesions.

Cited by 41 publications

References 6 publications

Imaging features of primary hepatic leiomyosarcoma: A case report and review of literature

Imaging features of primary hepatic leiomyosarcoma: A case report and review of literature

Primary hepatic leiomyosarcoma in a patient with autosomal dominant polycystic kidney disease

Primary Hepatic Leiomyosarcoma A Space Occupying Lesion in the Liver: An Enigma for Diagnosis

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