Primary liver tumors

Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma

“…1,2 It carries a high cancer morbidity and mortality because by the time of clinical presentation, more than 80% of patients are at the advance inoperable stage. 2,3 The low efficacy of current screening regime by serum alpha-fetoprotein measurements and transabdominal ultrasound imaging has rendered most patients not being diagnosed in time for curative surgery.Thus, underpinning the genetic events associated with hepatocellular carcinoma is expected to improve our understanding on liver carcinogenesis and also potentially provide biomarkers that are of diagnosis and prognostic values.Molecular studies using loss of heterozygosity analysis and comparative genomic hybridization have revealed recurrent chromosomal changes in hepatocellular carcinoma including losses on 1p, 4q, 6q, 8p, 11q, 13q, 16q and 17p. [4][5][6] As diminutions on 4q, 8p, 16q and 17p have been described in the nontumorous cirrhotic nodules and early preneoplastic liver dysplasia, these changes have been further implicated in the early carcinogenetic events of hepatocellular carcinoma.…”

“…1,2 It carries a high cancer morbidity and mortality because by the time of clinical presentation, more than 80% of patients are at the advance inoperable stage. 2,3 The low efficacy of current screening regime by serum alpha-fetoprotein measurements and transabdominal ultrasound imaging has rendered most patients not being diagnosed in time for curative surgery.…”

Long-Term Survival of a Patient with a Large Unresectable Hepatocellular Carcinoma: Case Report and Review of the Literature~!2010-04-28~!2010-05-29~!2010-07-23~!

“…Hepatic artery chemoembolization (HACE) was initially developed as an alternative treatment for unresectable nondisseminated liver tumors [8]. HACE has proved to be potentially more effective than systemic chemotherapy, intraarterial chemotherapy with embolization and mechanical embolization [9].…”

“…HACE has proved to be potentially more effective than systemic chemotherapy, intraarterial chemotherapy with embolization and mechanical embolization [9]. Some investigators reported that HACE in patients with borderline resectable tumors caused sufficient tumor shrinkage to allow resection [8].…”

Liver transplantation in hepatocellular carcinoma

“…Cirrhosis itself is the major risk factor for the development of HCC [2][3][4][5][6] . Overall, 80%-90% of HCC develop in the context of liver cirrhosis [7] .…”